IR780-loaded TPGS-TOS micelles for breast cancer photodynamic therapy

Detalhes bibliográficos
Autor(a) principal: Silva, Cleide Isabel Pais
Data de Publicação: 2017
Outros Autores: Diogo, Duarte Miguel de Melo, Correia, Ilídio Joaquim Sobreira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/4695
Resumo: IR780 iodide is a near-infrared (NIR) dye with a huge potential for cancer imaging and phototherapy. However, its biomedical application is strongly impaired by its lipophilic character. Herein, amphiphilic micelles based on d-α-tocopheryl polyethylene glycol succinate (TPGS) and d-α-tocopheryl succinate (TOS), two vitamin E derivatives with intrinsic anticancer activity, are explored to load IR780. IR780-loaded micelles with suitable sizes are obtained by using specific TPGS and TOS weight feed ratios during micelles formulation and these are able to encapsulate IR780 with high efficiency. In in vitro assays, the IR780-loaded micelles induce a cytotoxic effect in cancer cells upon exposure to NIR irradiation through the generation of reactive oxygen species (photodynamic therapy). This effective ablation of cancer cells is achieved using an ultra-low IR780 concentration. Moreover, IR780-loaded micelles also have the ability to act as photothermal and imaging agents, which widens their therapeutic and diagnostic potential. Overall, TPGS-TOS micelles are promising nanoplatforms for IR780-mediated cancer phototherapy and imaging.
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spelling IR780-loaded TPGS-TOS micelles for breast cancer photodynamic therapyBreast cancerPhotodynamic therapyPhotothermal therapyTPGS-TOS micellesIR780 iodideIR780 iodide is a near-infrared (NIR) dye with a huge potential for cancer imaging and phototherapy. However, its biomedical application is strongly impaired by its lipophilic character. Herein, amphiphilic micelles based on d-α-tocopheryl polyethylene glycol succinate (TPGS) and d-α-tocopheryl succinate (TOS), two vitamin E derivatives with intrinsic anticancer activity, are explored to load IR780. IR780-loaded micelles with suitable sizes are obtained by using specific TPGS and TOS weight feed ratios during micelles formulation and these are able to encapsulate IR780 with high efficiency. In in vitro assays, the IR780-loaded micelles induce a cytotoxic effect in cancer cells upon exposure to NIR irradiation through the generation of reactive oxygen species (photodynamic therapy). This effective ablation of cancer cells is achieved using an ultra-low IR780 concentration. Moreover, IR780-loaded micelles also have the ability to act as photothermal and imaging agents, which widens their therapeutic and diagnostic potential. Overall, TPGS-TOS micelles are promising nanoplatforms for IR780-mediated cancer phototherapy and imaging.ElsevieruBibliorumSilva, Cleide Isabel PaisDiogo, Duarte Miguel de MeloCorreia, Ilídio Joaquim Sobreira2018-03-22T09:02:00Z2017-01-112017-01-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/4695engPais-Silva, C., de Melo-Diogo e Correia, I. J (2017) “IR780-loaded TPGS-TOS micelles for breast cancer photodynamic therapy.” European Journal of Pharmaceutics and Biopharmaceutics, Vol.113, pp.108-11710.1016/j.ejpb.2017.01.002metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-15T09:41:58Zoai:ubibliorum.ubi.pt:10400.6/4695Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:45:44.858264Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv IR780-loaded TPGS-TOS micelles for breast cancer photodynamic therapy
title IR780-loaded TPGS-TOS micelles for breast cancer photodynamic therapy
spellingShingle IR780-loaded TPGS-TOS micelles for breast cancer photodynamic therapy
Silva, Cleide Isabel Pais
Breast cancer
Photodynamic therapy
Photothermal therapy
TPGS-TOS micelles
IR780 iodide
title_short IR780-loaded TPGS-TOS micelles for breast cancer photodynamic therapy
title_full IR780-loaded TPGS-TOS micelles for breast cancer photodynamic therapy
title_fullStr IR780-loaded TPGS-TOS micelles for breast cancer photodynamic therapy
title_full_unstemmed IR780-loaded TPGS-TOS micelles for breast cancer photodynamic therapy
title_sort IR780-loaded TPGS-TOS micelles for breast cancer photodynamic therapy
author Silva, Cleide Isabel Pais
author_facet Silva, Cleide Isabel Pais
Diogo, Duarte Miguel de Melo
Correia, Ilídio Joaquim Sobreira
author_role author
author2 Diogo, Duarte Miguel de Melo
Correia, Ilídio Joaquim Sobreira
author2_role author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Silva, Cleide Isabel Pais
Diogo, Duarte Miguel de Melo
Correia, Ilídio Joaquim Sobreira
dc.subject.por.fl_str_mv Breast cancer
Photodynamic therapy
Photothermal therapy
TPGS-TOS micelles
IR780 iodide
topic Breast cancer
Photodynamic therapy
Photothermal therapy
TPGS-TOS micelles
IR780 iodide
description IR780 iodide is a near-infrared (NIR) dye with a huge potential for cancer imaging and phototherapy. However, its biomedical application is strongly impaired by its lipophilic character. Herein, amphiphilic micelles based on d-α-tocopheryl polyethylene glycol succinate (TPGS) and d-α-tocopheryl succinate (TOS), two vitamin E derivatives with intrinsic anticancer activity, are explored to load IR780. IR780-loaded micelles with suitable sizes are obtained by using specific TPGS and TOS weight feed ratios during micelles formulation and these are able to encapsulate IR780 with high efficiency. In in vitro assays, the IR780-loaded micelles induce a cytotoxic effect in cancer cells upon exposure to NIR irradiation through the generation of reactive oxygen species (photodynamic therapy). This effective ablation of cancer cells is achieved using an ultra-low IR780 concentration. Moreover, IR780-loaded micelles also have the ability to act as photothermal and imaging agents, which widens their therapeutic and diagnostic potential. Overall, TPGS-TOS micelles are promising nanoplatforms for IR780-mediated cancer phototherapy and imaging.
publishDate 2017
dc.date.none.fl_str_mv 2017-01-11
2017-01-11T00:00:00Z
2018-03-22T09:02:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.6/4695
url http://hdl.handle.net/10400.6/4695
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pais-Silva, C., de Melo-Diogo e Correia, I. J (2017) “IR780-loaded TPGS-TOS micelles for breast cancer photodynamic therapy.” European Journal of Pharmaceutics and Biopharmaceutics, Vol.113, pp.108-117
10.1016/j.ejpb.2017.01.002
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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