The Impact of the Use of Glycomacropeptide on Satiety and Dietary Intake in Phenylketonuria
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/105687 |
Resumo: | Protein is the most satiating macronutrient, increasing secretion of gastrointestinal hormones and diet induced thermogenesis. In phenylketonuria (PKU), natural protein is restricted with approximately 80% of intake supplied by a synthetic protein source, which may alter satiety response. Casein glycomacropeptide (CGMP-AA), a carbohydrate containing peptide and alternative protein substitute to amino acids (AA), may enhance satiety mediated by its bioactive properties. AIM: In a three-year longitudinal; prospective study, the effect of AA and two different amounts of CGMP-AA (CGMP-AA only (CGMP100) and a combination of CGMP-AA and AA (CGMP50) on satiety, weight and body mass index (BMI) were compared. METHODS: 48 children with PKU completed the study. Median ages of children were: CGMP100; (n = 13), 9.2 years; CGMP50; (n = 16), 7.3 years; and AA (n = 19), 11.1 years. Semi-quantitative dietary assessments and anthropometry (weight, height and BMI) were measured every three months. RESULTS: The macronutrient contribution to total energy intake from protein, carbohydrate and fat was similar across the groups. Adjusting for age and gender, no differences in energy intake, weight, BMI, incidence of overweight or obesity was apparent between the groups. CONCLUSION: In this three-year longitudinal study, there was no indication to support a relationship between CGMP and satiety, as evidenced by decreased energy intake, thereby preventing overweight or obesity. Satiety is a complex multi-system process that is not fully understood. |
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The Impact of the Use of Glycomacropeptide on Satiety and Dietary Intake in PhenylketonuriaglycomacropeptidephenylketonuriaPKUsatietyFood ScienceNutrition and DieteticsSDG 3 - Good Health and Well-beingProtein is the most satiating macronutrient, increasing secretion of gastrointestinal hormones and diet induced thermogenesis. In phenylketonuria (PKU), natural protein is restricted with approximately 80% of intake supplied by a synthetic protein source, which may alter satiety response. Casein glycomacropeptide (CGMP-AA), a carbohydrate containing peptide and alternative protein substitute to amino acids (AA), may enhance satiety mediated by its bioactive properties. AIM: In a three-year longitudinal; prospective study, the effect of AA and two different amounts of CGMP-AA (CGMP-AA only (CGMP100) and a combination of CGMP-AA and AA (CGMP50) on satiety, weight and body mass index (BMI) were compared. METHODS: 48 children with PKU completed the study. Median ages of children were: CGMP100; (n = 13), 9.2 years; CGMP50; (n = 16), 7.3 years; and AA (n = 19), 11.1 years. Semi-quantitative dietary assessments and anthropometry (weight, height and BMI) were measured every three months. RESULTS: The macronutrient contribution to total energy intake from protein, carbohydrate and fat was similar across the groups. Adjusting for age and gender, no differences in energy intake, weight, BMI, incidence of overweight or obesity was apparent between the groups. CONCLUSION: In this three-year longitudinal study, there was no indication to support a relationship between CGMP and satiety, as evidenced by decreased energy intake, thereby preventing overweight or obesity. Satiety is a complex multi-system process that is not fully understood.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNDaly, AnneEvans, SharonPinto, AlexJackson, RichardAshmore, CatherineRocha, Júlio CésarMacDonald, Anita2020-10-15T22:50:11Z2020-09-042020-09-04T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/105687eng1422-8599PURE: 20031774https://doi.org/10.3390/nu12092704info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:50:53Zoai:run.unl.pt:10362/105687Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:40:33.454548Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The Impact of the Use of Glycomacropeptide on Satiety and Dietary Intake in Phenylketonuria |
title |
The Impact of the Use of Glycomacropeptide on Satiety and Dietary Intake in Phenylketonuria |
spellingShingle |
The Impact of the Use of Glycomacropeptide on Satiety and Dietary Intake in Phenylketonuria Daly, Anne glycomacropeptide phenylketonuria PKU satiety Food Science Nutrition and Dietetics SDG 3 - Good Health and Well-being |
title_short |
The Impact of the Use of Glycomacropeptide on Satiety and Dietary Intake in Phenylketonuria |
title_full |
The Impact of the Use of Glycomacropeptide on Satiety and Dietary Intake in Phenylketonuria |
title_fullStr |
The Impact of the Use of Glycomacropeptide on Satiety and Dietary Intake in Phenylketonuria |
title_full_unstemmed |
The Impact of the Use of Glycomacropeptide on Satiety and Dietary Intake in Phenylketonuria |
title_sort |
The Impact of the Use of Glycomacropeptide on Satiety and Dietary Intake in Phenylketonuria |
author |
Daly, Anne |
author_facet |
Daly, Anne Evans, Sharon Pinto, Alex Jackson, Richard Ashmore, Catherine Rocha, Júlio César MacDonald, Anita |
author_role |
author |
author2 |
Evans, Sharon Pinto, Alex Jackson, Richard Ashmore, Catherine Rocha, Júlio César MacDonald, Anita |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Daly, Anne Evans, Sharon Pinto, Alex Jackson, Richard Ashmore, Catherine Rocha, Júlio César MacDonald, Anita |
dc.subject.por.fl_str_mv |
glycomacropeptide phenylketonuria PKU satiety Food Science Nutrition and Dietetics SDG 3 - Good Health and Well-being |
topic |
glycomacropeptide phenylketonuria PKU satiety Food Science Nutrition and Dietetics SDG 3 - Good Health and Well-being |
description |
Protein is the most satiating macronutrient, increasing secretion of gastrointestinal hormones and diet induced thermogenesis. In phenylketonuria (PKU), natural protein is restricted with approximately 80% of intake supplied by a synthetic protein source, which may alter satiety response. Casein glycomacropeptide (CGMP-AA), a carbohydrate containing peptide and alternative protein substitute to amino acids (AA), may enhance satiety mediated by its bioactive properties. AIM: In a three-year longitudinal; prospective study, the effect of AA and two different amounts of CGMP-AA (CGMP-AA only (CGMP100) and a combination of CGMP-AA and AA (CGMP50) on satiety, weight and body mass index (BMI) were compared. METHODS: 48 children with PKU completed the study. Median ages of children were: CGMP100; (n = 13), 9.2 years; CGMP50; (n = 16), 7.3 years; and AA (n = 19), 11.1 years. Semi-quantitative dietary assessments and anthropometry (weight, height and BMI) were measured every three months. RESULTS: The macronutrient contribution to total energy intake from protein, carbohydrate and fat was similar across the groups. Adjusting for age and gender, no differences in energy intake, weight, BMI, incidence of overweight or obesity was apparent between the groups. CONCLUSION: In this three-year longitudinal study, there was no indication to support a relationship between CGMP and satiety, as evidenced by decreased energy intake, thereby preventing overweight or obesity. Satiety is a complex multi-system process that is not fully understood. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-10-15T22:50:11Z 2020-09-04 2020-09-04T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/105687 |
url |
http://hdl.handle.net/10362/105687 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1422-8599 PURE: 20031774 https://doi.org/10.3390/nu12092704 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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