Methadone, Pierre Robin sequence and other congenital anomalies: case-control study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.18/7918 |
Resumo: | Carlos Matias Dias - Centro de Estudos e Registo de Anomalias Congénitas, Instituto Nacional de Saúde Doutor Ricardo Jorge |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Methadone, Pierre Robin sequence and other congenital anomalies: case-control studyPierre Robin SequenceCleft PalateMethadoneOpioid Use DisorderEstados de Saúde e de DoençaObservação em Saúde e VigilânciaRENACRegisto Nacional de Anomalias CongénitasCarlos Matias Dias - Centro de Estudos e Registo de Anomalias Congénitas, Instituto Nacional de Saúde Doutor Ricardo JorgeObjective: Methadone is a vital treatment for women with opioid use disorder in pregnancy. Previous reports suggested an association between methadone exposure and Pierre Robin sequence (PRS), a rare craniofacial anomaly. We assessed the association between gestational methadone exposure and PRS. Design/setting: This case-malformed control study used European Surveillance of Congenital Anomalies population-based registries in Ireland, the Netherlands, Italy, Switzerland, Croatia, Malta, Portugal, Germany, Wales, Norway and Spain, 1995-2011. Patients: Cases included PRS based on International Classification of Disease (ICD), Ninth Edition-British Paediatric Association (BPA) code 75 603 or ICD, Tenth Edition-BPA code Q8708. Malformed controls were all non-PRS anomalies, excluding genetic conditions, among live births, fetal deaths from 20 weeks' gestation and terminations of pregnancy for fetal anomalies. An exploratory analysis assessed the association between methadone exposure and other congenital anomalies (CAs) excluding PRS. Methadone exposure was ascertained from medical records and maternal interview. Results: Among 87 979 CA registrations, there were 127 methadone-exposed pregnancies and 336 PRS cases. There was an association between methadone exposure and PRS (OR adjusted for registry 12.3, 95% CI 5.7 to 26.8). In absolute terms, this association reflects a risk increase from approximately 1-12 cases per 10 000 births. A raised OR was found for cleft palate (adjusted OR 5.0, 95% CI 2.7 to 9.2). Conclusions: These findings suggest that gestational methadone exposure is associated with PRS. The association may be explained by unmeasured confounding factors. The small increased risk of PRS in itself does not alter the risk-benefit balance for gestational methadone use. The association with cleft palate, a more common CA, should be assessed with independent data.BMJ Publishing Group/ Royal College of Paediatrics and Child HealthRepositório Científico do Instituto Nacional de SaúdeCleary, BrianLoane, MariaAddor, Marie-ClaudeBarisic, Ingeborgde Walle, Hermien E.K.Matias Dias, CarlosGatt, MiriamKlungsoyr, KariMcDonnell, BobNeville, AmandaPierini, AnnaRissmann, AnkeTucker, David F.Zurriaga, OscarDolk, Helen2022-02-03T15:35:04Z2020-032020-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/7918engArch Dis Child Fetal Neonatal Ed . 2020 Mar;105(2):151-157. doi: 10.1136/archdischild-2019-316804. Epub 2019 Jun 22.1359-299810.1136/archdischild-2019-316804info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:15Zoai:repositorio.insa.pt:10400.18/7918Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:42:30.294915Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Methadone, Pierre Robin sequence and other congenital anomalies: case-control study |
| title |
Methadone, Pierre Robin sequence and other congenital anomalies: case-control study |
| spellingShingle |
Methadone, Pierre Robin sequence and other congenital anomalies: case-control study Cleary, Brian Pierre Robin Sequence Cleft Palate Methadone Opioid Use Disorder Estados de Saúde e de Doença Observação em Saúde e Vigilância RENAC Registo Nacional de Anomalias Congénitas |
| title_short |
Methadone, Pierre Robin sequence and other congenital anomalies: case-control study |
| title_full |
Methadone, Pierre Robin sequence and other congenital anomalies: case-control study |
| title_fullStr |
Methadone, Pierre Robin sequence and other congenital anomalies: case-control study |
| title_full_unstemmed |
Methadone, Pierre Robin sequence and other congenital anomalies: case-control study |
| title_sort |
Methadone, Pierre Robin sequence and other congenital anomalies: case-control study |
| author |
Cleary, Brian |
| author_facet |
Cleary, Brian Loane, Maria Addor, Marie-Claude Barisic, Ingeborg de Walle, Hermien E.K. Matias Dias, Carlos Gatt, Miriam Klungsoyr, Kari McDonnell, Bob Neville, Amanda Pierini, Anna Rissmann, Anke Tucker, David F. Zurriaga, Oscar Dolk, Helen |
| author_role |
author |
| author2 |
Loane, Maria Addor, Marie-Claude Barisic, Ingeborg de Walle, Hermien E.K. Matias Dias, Carlos Gatt, Miriam Klungsoyr, Kari McDonnell, Bob Neville, Amanda Pierini, Anna Rissmann, Anke Tucker, David F. Zurriaga, Oscar Dolk, Helen |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
Cleary, Brian Loane, Maria Addor, Marie-Claude Barisic, Ingeborg de Walle, Hermien E.K. Matias Dias, Carlos Gatt, Miriam Klungsoyr, Kari McDonnell, Bob Neville, Amanda Pierini, Anna Rissmann, Anke Tucker, David F. Zurriaga, Oscar Dolk, Helen |
| dc.subject.por.fl_str_mv |
Pierre Robin Sequence Cleft Palate Methadone Opioid Use Disorder Estados de Saúde e de Doença Observação em Saúde e Vigilância RENAC Registo Nacional de Anomalias Congénitas |
| topic |
Pierre Robin Sequence Cleft Palate Methadone Opioid Use Disorder Estados de Saúde e de Doença Observação em Saúde e Vigilância RENAC Registo Nacional de Anomalias Congénitas |
| description |
Carlos Matias Dias - Centro de Estudos e Registo de Anomalias Congénitas, Instituto Nacional de Saúde Doutor Ricardo Jorge |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-03 2020-03-01T00:00:00Z 2022-02-03T15:35:04Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/7918 |
| url |
http://hdl.handle.net/10400.18/7918 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Arch Dis Child Fetal Neonatal Ed . 2020 Mar;105(2):151-157. doi: 10.1136/archdischild-2019-316804. Epub 2019 Jun 22. 1359-2998 10.1136/archdischild-2019-316804 |
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info:eu-repo/semantics/embargoedAccess |
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embargoedAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
BMJ Publishing Group/ Royal College of Paediatrics and Child Health |
| publisher.none.fl_str_mv |
BMJ Publishing Group/ Royal College of Paediatrics and Child Health |
| dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132170698096640 |