Understanding COPD: a vision on phenotypes, comorbidities and treatment approach.
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.10/1589 |
Resumo: | Chronic Obstructive Pulmonary Disease (COPD) phenotypes have become increasingly recognized as important for grouping patients with similar presentation and/or behavior, within the heterogeneity of the disease. The primary aim of identifying phenotypes is to provide patients with the best health care possible, tailoring the therapeutic approach to each patient. However, the identification of specific phenotypes has been hindered by several factors such as which specific attributes are relevant, which discriminant features should be used for assigning patients to specific phenotypes, and how relevant are they to the therapeutic approach, prognostic and clinical outcome. Moreover, the definition of phenotype is still not consensual. Comorbidities, risk factors, modifiable risk factors and disease severity, although not phenotypes, have impact across all COPD phenotypes. Although there are some identified phenotypes that are fairly consensual, many others have been proposed, but currently lack validation. The on-going debate about which instruments and tests should be used in the identification and definition of phenotypes has contributed to this uncertainty. In this paper, the authors review present knowledge regarding COPD phenotyping, discuss the role of phenotypes and comorbidities on the severity of COPD, propose new phenotypes and suggest a phenotype-based pharmacological therapeutic approach. The authors conclude that a patient-tailored treatment approach, which takes into account each patient's specific attributes and specificities, should be pursued. |
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Understanding COPD: a vision on phenotypes, comorbidities and treatment approach.Chronic obstructive pulmonary diseaseDoença pulmonar obstrutiva crónicaComorbidityComorbilidadePhenotypeFenótipoChronic Obstructive Pulmonary Disease (COPD) phenotypes have become increasingly recognized as important for grouping patients with similar presentation and/or behavior, within the heterogeneity of the disease. The primary aim of identifying phenotypes is to provide patients with the best health care possible, tailoring the therapeutic approach to each patient. However, the identification of specific phenotypes has been hindered by several factors such as which specific attributes are relevant, which discriminant features should be used for assigning patients to specific phenotypes, and how relevant are they to the therapeutic approach, prognostic and clinical outcome. Moreover, the definition of phenotype is still not consensual. Comorbidities, risk factors, modifiable risk factors and disease severity, although not phenotypes, have impact across all COPD phenotypes. Although there are some identified phenotypes that are fairly consensual, many others have been proposed, but currently lack validation. The on-going debate about which instruments and tests should be used in the identification and definition of phenotypes has contributed to this uncertainty. In this paper, the authors review present knowledge regarding COPD phenotyping, discuss the role of phenotypes and comorbidities on the severity of COPD, propose new phenotypes and suggest a phenotype-based pharmacological therapeutic approach. The authors conclude that a patient-tailored treatment approach, which takes into account each patient's specific attributes and specificities, should be pursued.Sociedade Portuguesa de PneumologiaRepositório do Hospital Prof. Doutor Fernando FonsecaFragoso, EAndré, SBoléo-Tomé, JPAreias, VMunhá, JCardoso, JGI DPOC-Grupo de Interesse na Doença Pulmonar Obstrutiva Crónica2016-03-28T13:49:12Z2016-01-01T00:00:00Z2016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.10/1589engRev Port Pneumol. 2016 Mar-Apr;22(2):101-112173-511510.1016/j.rppnen.2015.12.001info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-20T15:52:20Zoai:repositorio.hff.min-saude.pt:10400.10/1589Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:52:40.097006Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Understanding COPD: a vision on phenotypes, comorbidities and treatment approach. |
title |
Understanding COPD: a vision on phenotypes, comorbidities and treatment approach. |
spellingShingle |
Understanding COPD: a vision on phenotypes, comorbidities and treatment approach. Fragoso, E Chronic obstructive pulmonary disease Doença pulmonar obstrutiva crónica Comorbidity Comorbilidade Phenotype Fenótipo |
title_short |
Understanding COPD: a vision on phenotypes, comorbidities and treatment approach. |
title_full |
Understanding COPD: a vision on phenotypes, comorbidities and treatment approach. |
title_fullStr |
Understanding COPD: a vision on phenotypes, comorbidities and treatment approach. |
title_full_unstemmed |
Understanding COPD: a vision on phenotypes, comorbidities and treatment approach. |
title_sort |
Understanding COPD: a vision on phenotypes, comorbidities and treatment approach. |
author |
Fragoso, E |
author_facet |
Fragoso, E André, S Boléo-Tomé, JP Areias, V Munhá, J Cardoso, J GI DPOC-Grupo de Interesse na Doença Pulmonar Obstrutiva Crónica |
author_role |
author |
author2 |
André, S Boléo-Tomé, JP Areias, V Munhá, J Cardoso, J GI DPOC-Grupo de Interesse na Doença Pulmonar Obstrutiva Crónica |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Hospital Prof. Doutor Fernando Fonseca |
dc.contributor.author.fl_str_mv |
Fragoso, E André, S Boléo-Tomé, JP Areias, V Munhá, J Cardoso, J GI DPOC-Grupo de Interesse na Doença Pulmonar Obstrutiva Crónica |
dc.subject.por.fl_str_mv |
Chronic obstructive pulmonary disease Doença pulmonar obstrutiva crónica Comorbidity Comorbilidade Phenotype Fenótipo |
topic |
Chronic obstructive pulmonary disease Doença pulmonar obstrutiva crónica Comorbidity Comorbilidade Phenotype Fenótipo |
description |
Chronic Obstructive Pulmonary Disease (COPD) phenotypes have become increasingly recognized as important for grouping patients with similar presentation and/or behavior, within the heterogeneity of the disease. The primary aim of identifying phenotypes is to provide patients with the best health care possible, tailoring the therapeutic approach to each patient. However, the identification of specific phenotypes has been hindered by several factors such as which specific attributes are relevant, which discriminant features should be used for assigning patients to specific phenotypes, and how relevant are they to the therapeutic approach, prognostic and clinical outcome. Moreover, the definition of phenotype is still not consensual. Comorbidities, risk factors, modifiable risk factors and disease severity, although not phenotypes, have impact across all COPD phenotypes. Although there are some identified phenotypes that are fairly consensual, many others have been proposed, but currently lack validation. The on-going debate about which instruments and tests should be used in the identification and definition of phenotypes has contributed to this uncertainty. In this paper, the authors review present knowledge regarding COPD phenotyping, discuss the role of phenotypes and comorbidities on the severity of COPD, propose new phenotypes and suggest a phenotype-based pharmacological therapeutic approach. The authors conclude that a patient-tailored treatment approach, which takes into account each patient's specific attributes and specificities, should be pursued. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-03-28T13:49:12Z 2016-01-01T00:00:00Z 2016-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.10/1589 |
url |
http://hdl.handle.net/10400.10/1589 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Rev Port Pneumol. 2016 Mar-Apr;22(2):101-11 2173-5115 10.1016/j.rppnen.2015.12.001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Pneumologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Pneumologia |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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