In vitro evaluation of bovine lactoferrin potential as an anticancer agent

Detalhes bibliográficos
Autor(a) principal: Zhang, Yunlei
Data de Publicação: 2015
Outros Autores: Lima, Cristóvão F., Rodrigues, L. R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/31817
Resumo: "Available online 2 September 2014"
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spelling In vitro evaluation of bovine lactoferrin potential as an anticancer agentScience & Technology"Available online 2 September 2014"Bovine lactoferrin (bLF) was shown to efficiently inhibit the growth of MCF-7, T-47D, MDA-MB-231 and Hs578T breast cancer cells in a concentration-dependent manner. However, apoptosis was only induced in MCF-7 cells, which was associated with the mitochondria membrane depolarisation and a decrease of Bcl-2 levels. bLF led to the cycle arrest of MCF-7 cells at G1/G0 phase, as well as a significant decrease in the expression of CDC25c. The possibility that the observed anticancer effects could be due to the high exogenous bLF concentrations in the culture media was excluded. Moreover, bLF was shown to restrain the colony formation of MCF-7 cells, although it promoted cell migration. This later effect was unspecific and related to the presence of a high protein concentration in the culture or medium. The results gathered in this work provide valuable insights for the evaluation and further study of the potential of bLF in cancer therapy.Zhang Y. acknowledges the Erasmus Mundus External Cooperation window (Bridging the Gap) for supporting his PhD grant. The authors acknowledge the financial support from the Strategic Projects PEst-OE/EQB/LA0023/2013 and PEst-OE/AGR/UI4033/2014, as well as the project ref. RECI/BBB-EBI/0179/2012 (project number FCOMP-01-0124-FEDER-027462) funded by Fundacao para a Ciencia e a Tecnologia, Portugal.ElsevierUniversidade do MinhoZhang, YunleiLima, Cristóvão F.Rodrigues, L. R.20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/31817eng0958-694610.1016/j.idairyj.2014.08.016info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:30:06Zoai:repositorium.sdum.uminho.pt:1822/31817Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:25:12.841808Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv In vitro evaluation of bovine lactoferrin potential as an anticancer agent
title In vitro evaluation of bovine lactoferrin potential as an anticancer agent
spellingShingle In vitro evaluation of bovine lactoferrin potential as an anticancer agent
Zhang, Yunlei
Science & Technology
title_short In vitro evaluation of bovine lactoferrin potential as an anticancer agent
title_full In vitro evaluation of bovine lactoferrin potential as an anticancer agent
title_fullStr In vitro evaluation of bovine lactoferrin potential as an anticancer agent
title_full_unstemmed In vitro evaluation of bovine lactoferrin potential as an anticancer agent
title_sort In vitro evaluation of bovine lactoferrin potential as an anticancer agent
author Zhang, Yunlei
author_facet Zhang, Yunlei
Lima, Cristóvão F.
Rodrigues, L. R.
author_role author
author2 Lima, Cristóvão F.
Rodrigues, L. R.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Zhang, Yunlei
Lima, Cristóvão F.
Rodrigues, L. R.
dc.subject.por.fl_str_mv Science & Technology
topic Science & Technology
description "Available online 2 September 2014"
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/31817
url http://hdl.handle.net/1822/31817
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0958-6946
10.1016/j.idairyj.2014.08.016
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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