Concurrence of Gestational Diabetes and Pre-Gravid Obesity ("Diabesity") in Twin Gestations

• Autor(a) principal: Simões, T
• Data de Publicação: 2016
• Outros Autores: Queirós, A, Valdoleiros, S, Marujo, AT, Felix, N, Blickstein, I
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.17/2692
• topic: MAC MED MAF; Birth Weight; Body Mass Index; Cesarean Section/statistics & numerical data; Diabetes, Gestational/epidemiology; Gestational Age; Hypertension/complications; Hypertension/epidemiology; Obesity/complications; Obesity/epidemiology; Pre-Eclampsia/epidemiology; Pregnancy; Pregnancy Complications/epidemiology; Pregnancy, Twin; Stillbirth/epidemiology

OBJECTIVE: To assess the effect of the concurrence of gestational diabetes mellitus (GDM) and pre-gravid obesity in twin gestations ("diabesity"). METHODS: We compared perinatal outcomes of twin gestation in mothers with GDM and pre-gravid obesity (1.7%), mothers with GDM but with normal BMI (6.2%), and obese mothers without GDM (7.0%). RESULTS: Twin pregnancies with "diabesity" were associated with significantly higher incidence of stillbirth (OR = 6.4; 95%CI = 1.4, 33.4) and existing chronic hypertension (OR = 4.2; 95%CI = 1.2, 14.8) than in GDM pregnancies without obesity, and with births at 33-36 weeks as compared with the other groups. Otherwise, the comparisons showed remarkable similar results in terms of gestational age, birth weight, preeclampsia, cesarean section rate, and fetal-neonatal outcomes. CONCLUSION: It appears that diabesity has a relatively minor effect in twins. If this will be confirmed by other studies, it would be important to elucidate how twins ameliorate the adverse outcomes of diabesity.