New steroidal aromatase inhibitors: biological effects in hormone-dependent breast cancer cell models
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.34624/captar.v6i1.13117 |
Resumo: | Aromatase inhibitors (AIs) are currently used as a first-line therapeutic approach for hormone-dependent (ER+) breast tumors in postmenopausal women, the most common type of cancer diagnosed among women, in which estrogen plays a key role. Aromatase is the enzyme responsible for estrogen biosynthesis, so its inhibition results in estrogen suppression, avoiding tumor growth. However, the existence of side-effects with the current AIs used in clinic, such as development of therapy resistance and bone loss, justifies the search for new AIs. In the past few years, several steroidal compounds have been synthesized with structural modifications in androstenedione, the aromatase substrate, in order to achieve maximum inhibitory effects on aromatase. The present work aims to continue this research line, so newly synthesized steroidal compounds (49, 50, 51 and 52) with structural modifications on A-, B- and D-rings are under biological evaluation, using different human breast cancer cell lines, an ER+ aromatase overexpressing breast cancer cell line (MCF-7aro), an ER- breast cancer cell line (SK-BR-3) and a late stage of acquired endocrine resistance cell line (LTEDaro). [...] |
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New steroidal aromatase inhibitors: biological effects in hormone-dependent breast cancer cell modelsAromatase inhibitors (AIs) are currently used as a first-line therapeutic approach for hormone-dependent (ER+) breast tumors in postmenopausal women, the most common type of cancer diagnosed among women, in which estrogen plays a key role. Aromatase is the enzyme responsible for estrogen biosynthesis, so its inhibition results in estrogen suppression, avoiding tumor growth. However, the existence of side-effects with the current AIs used in clinic, such as development of therapy resistance and bone loss, justifies the search for new AIs. In the past few years, several steroidal compounds have been synthesized with structural modifications in androstenedione, the aromatase substrate, in order to achieve maximum inhibitory effects on aromatase. The present work aims to continue this research line, so newly synthesized steroidal compounds (49, 50, 51 and 52) with structural modifications on A-, B- and D-rings are under biological evaluation, using different human breast cancer cell lines, an ER+ aromatase overexpressing breast cancer cell line (MCF-7aro), an ER- breast cancer cell line (SK-BR-3) and a late stage of acquired endocrine resistance cell line (LTEDaro). [...]Revista Captar: Ciência e Ambiente para TodosRevista Captar: Ciência e Ambiente para Todos2016-01-01T00:00:00Zjournal articleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.34624/captar.v6i1.13117oai:proa.ua.pt:article/13117Revista Captar: Ciência e Ambiente para Todos; Vol 6 No 1 (2016); 62-63Revista Captar: Ciência e Ambiente para Todos; vol. 6 n.º 1 (2016); 62-631647-323Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://proa.ua.pt/index.php/captar/article/view/13117https://doi.org/10.34624/captar.v6i1.13117https://proa.ua.pt/index.php/captar/article/view/13117/8739https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessSobral, Ana FilipaAmaral, CristinaVarela, CarlaTavares, ElisiárioRoleira, FernandaCorreia-Da-Silva, GeorginaTeixeira, NatérciaCampos, Saul2022-09-05T12:32:58Zoai:proa.ua.pt:article/13117Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:00:26.281777Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
New steroidal aromatase inhibitors: biological effects in hormone-dependent breast cancer cell models |
title |
New steroidal aromatase inhibitors: biological effects in hormone-dependent breast cancer cell models |
spellingShingle |
New steroidal aromatase inhibitors: biological effects in hormone-dependent breast cancer cell models Sobral, Ana Filipa |
title_short |
New steroidal aromatase inhibitors: biological effects in hormone-dependent breast cancer cell models |
title_full |
New steroidal aromatase inhibitors: biological effects in hormone-dependent breast cancer cell models |
title_fullStr |
New steroidal aromatase inhibitors: biological effects in hormone-dependent breast cancer cell models |
title_full_unstemmed |
New steroidal aromatase inhibitors: biological effects in hormone-dependent breast cancer cell models |
title_sort |
New steroidal aromatase inhibitors: biological effects in hormone-dependent breast cancer cell models |
author |
Sobral, Ana Filipa |
author_facet |
Sobral, Ana Filipa Amaral, Cristina Varela, Carla Tavares, Elisiário Roleira, Fernanda Correia-Da-Silva, Georgina Teixeira, Natércia Campos, Saul |
author_role |
author |
author2 |
Amaral, Cristina Varela, Carla Tavares, Elisiário Roleira, Fernanda Correia-Da-Silva, Georgina Teixeira, Natércia Campos, Saul |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Sobral, Ana Filipa Amaral, Cristina Varela, Carla Tavares, Elisiário Roleira, Fernanda Correia-Da-Silva, Georgina Teixeira, Natércia Campos, Saul |
description |
Aromatase inhibitors (AIs) are currently used as a first-line therapeutic approach for hormone-dependent (ER+) breast tumors in postmenopausal women, the most common type of cancer diagnosed among women, in which estrogen plays a key role. Aromatase is the enzyme responsible for estrogen biosynthesis, so its inhibition results in estrogen suppression, avoiding tumor growth. However, the existence of side-effects with the current AIs used in clinic, such as development of therapy resistance and bone loss, justifies the search for new AIs. In the past few years, several steroidal compounds have been synthesized with structural modifications in androstenedione, the aromatase substrate, in order to achieve maximum inhibitory effects on aromatase. The present work aims to continue this research line, so newly synthesized steroidal compounds (49, 50, 51 and 52) with structural modifications on A-, B- and D-rings are under biological evaluation, using different human breast cancer cell lines, an ER+ aromatase overexpressing breast cancer cell line (MCF-7aro), an ER- breast cancer cell line (SK-BR-3) and a late stage of acquired endocrine resistance cell line (LTEDaro). [...] |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-01T00:00:00Z |
dc.type.driver.fl_str_mv |
journal article info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.34624/captar.v6i1.13117 oai:proa.ua.pt:article/13117 |
url |
https://doi.org/10.34624/captar.v6i1.13117 |
identifier_str_mv |
oai:proa.ua.pt:article/13117 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://proa.ua.pt/index.php/captar/article/view/13117 https://doi.org/10.34624/captar.v6i1.13117 https://proa.ua.pt/index.php/captar/article/view/13117/8739 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Revista Captar: Ciência e Ambiente para Todos Revista Captar: Ciência e Ambiente para Todos |
publisher.none.fl_str_mv |
Revista Captar: Ciência e Ambiente para Todos Revista Captar: Ciência e Ambiente para Todos |
dc.source.none.fl_str_mv |
Revista Captar: Ciência e Ambiente para Todos; Vol 6 No 1 (2016); 62-63 Revista Captar: Ciência e Ambiente para Todos; vol. 6 n.º 1 (2016); 62-63 1647-323X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799129875043319808 |