Pseudoappendicitis due to Yersinia pseudotuberculosis: A Case Report with a Fatal Outcome

Detalhes bibliográficos
Autor(a) principal: Antunes, Cláudia
Data de Publicação: 2024
Outros Autores: Antunes, Daniela, Santos, Cátia, Araújo, Ana, Pereira, Luís
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
DOI: 10.60591/crspmi.41
Texto Completo: https://doi.org/10.60591/crspmi.41
Resumo: Yersinia species often cause enterocolitis or pseudoappendicitis. Yersiniosis is mostly transmitted by raw or undercooked foods, namely pork. Clinical severity is related to states of immunosuppression or iron overload. We present the clinical case of a 79-year-old man with a history of hypertension and diabetes, who was admitted to the emergency department for right low back pain with anterior irradiation to the right iliac fossa (RIF). Analytically with leukocytosis, neutrophilia, and C-reactive protein and procalcitonin elevated. Abdominal computed tomography revealed a liquid collection of about 60 x 40 mm in the RIF. The clinical status evolved to septic shock with suspicion of starting point in appendicitis. Although antibiotic therapy with piperacillin/tazobactam, and isolation in blood cultures of susceptible Yersinia pseudotuberculosis, the patient eventually died. The low prevalence and the ability to mimic other diseases makes difficult to diagnose this entity. The case warns of the absence of response to early treatment with broad-spectrum antibiotic therapy, which questions the possibility of virulence factors yet to be identified, as well as the need to determine which antibiotic is more effective according to clinical severity.
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spelling Pseudoappendicitis due to Yersinia pseudotuberculosis: A Case Report with a Fatal OutcomePseudoapendicite Causada por Yersinia pseudotuberculosis: Um Caso Clínico com Evolução FatalCasos ClínicosYersinia species often cause enterocolitis or pseudoappendicitis. Yersiniosis is mostly transmitted by raw or undercooked foods, namely pork. Clinical severity is related to states of immunosuppression or iron overload. We present the clinical case of a 79-year-old man with a history of hypertension and diabetes, who was admitted to the emergency department for right low back pain with anterior irradiation to the right iliac fossa (RIF). Analytically with leukocytosis, neutrophilia, and C-reactive protein and procalcitonin elevated. Abdominal computed tomography revealed a liquid collection of about 60 x 40 mm in the RIF. The clinical status evolved to septic shock with suspicion of starting point in appendicitis. Although antibiotic therapy with piperacillin/tazobactam, and isolation in blood cultures of susceptible Yersinia pseudotuberculosis, the patient eventually died. The low prevalence and the ability to mimic other diseases makes difficult to diagnose this entity. The case warns of the absence of response to early treatment with broad-spectrum antibiotic therapy, which questions the possibility of virulence factors yet to be identified, as well as the need to determine which antibiotic is more effective according to clinical severity.As espécies de Yersinia causam frequentemente quadros de enterocolite ou pseudoapendicite. A yersiniose é maioritariamente transmitida por alimentos crus ou mal cozinhados, nomeadamente carne de porco. A gravidade clínica está relacionada com estados de imunodepressão ou de sobrecarga de ferro. Apresenta-se o caso clínico de um homem de 79 anos, com antecedentes de hipertensão e diabetes, que deu entrada no serviço de urgência por lombalgia direita com irradiação anterior para a fossa ilíaca direita (FID). Analiticamente com leucocitose, neutrofilia, e proteína C-reativa e procalcitonina elevadas. A tomografia computorizada abdominal revelou uma coleção líquida de cerca de 60x40 mm na FID. O quadro clínico evoluiu para choque séptico com suspeita de ponto de partida em apendicite. Apesar de iniciada antibioterapia com piperacilina/tazobactam, e ter sido isolada em hemoculturas Yersinia pseudotuberculosis sensível, o doente acabou por falecer. A baixa prevalência e a capacidade de mimetizar outras doenças dificulta o diagnóstico desta entidade. O caso alerta para a ausência de resposta ao tratamento precoce com antibioterapia de largo espectro, o que questiona a possibilidade de existência de fatores de virulência ainda por identificar, bem como para a necessidade de determinação de qual a antibioterapia mais eficaz de acordo com a gravidade clínica.Sociedade Portuguesa de Medicina Interna2024-02-26info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://doi.org/10.60591/crspmi.41eng2975-822XAntunes, CláudiaAntunes, DanielaSantos, CátiaAraújo, AnaPereira, Luísinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-02T09:45:25Zoai:ojs.casereports.spmi.pt:article/41Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:12:11.182796Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Pseudoappendicitis due to Yersinia pseudotuberculosis: A Case Report with a Fatal Outcome
Pseudoapendicite Causada por Yersinia pseudotuberculosis: Um Caso Clínico com Evolução Fatal
title Pseudoappendicitis due to Yersinia pseudotuberculosis: A Case Report with a Fatal Outcome
spellingShingle Pseudoappendicitis due to Yersinia pseudotuberculosis: A Case Report with a Fatal Outcome
Pseudoappendicitis due to Yersinia pseudotuberculosis: A Case Report with a Fatal Outcome
Antunes, Cláudia
Casos Clínicos
Antunes, Cláudia
Casos Clínicos
title_short Pseudoappendicitis due to Yersinia pseudotuberculosis: A Case Report with a Fatal Outcome
title_full Pseudoappendicitis due to Yersinia pseudotuberculosis: A Case Report with a Fatal Outcome
title_fullStr Pseudoappendicitis due to Yersinia pseudotuberculosis: A Case Report with a Fatal Outcome
Pseudoappendicitis due to Yersinia pseudotuberculosis: A Case Report with a Fatal Outcome
title_full_unstemmed Pseudoappendicitis due to Yersinia pseudotuberculosis: A Case Report with a Fatal Outcome
Pseudoappendicitis due to Yersinia pseudotuberculosis: A Case Report with a Fatal Outcome
title_sort Pseudoappendicitis due to Yersinia pseudotuberculosis: A Case Report with a Fatal Outcome
author Antunes, Cláudia
author_facet Antunes, Cláudia
Antunes, Cláudia
Antunes, Daniela
Santos, Cátia
Araújo, Ana
Pereira, Luís
Antunes, Daniela
Santos, Cátia
Araújo, Ana
Pereira, Luís
author_role author
author2 Antunes, Daniela
Santos, Cátia
Araújo, Ana
Pereira, Luís
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Antunes, Cláudia
Antunes, Daniela
Santos, Cátia
Araújo, Ana
Pereira, Luís
dc.subject.por.fl_str_mv Casos Clínicos
topic Casos Clínicos
description Yersinia species often cause enterocolitis or pseudoappendicitis. Yersiniosis is mostly transmitted by raw or undercooked foods, namely pork. Clinical severity is related to states of immunosuppression or iron overload. We present the clinical case of a 79-year-old man with a history of hypertension and diabetes, who was admitted to the emergency department for right low back pain with anterior irradiation to the right iliac fossa (RIF). Analytically with leukocytosis, neutrophilia, and C-reactive protein and procalcitonin elevated. Abdominal computed tomography revealed a liquid collection of about 60 x 40 mm in the RIF. The clinical status evolved to septic shock with suspicion of starting point in appendicitis. Although antibiotic therapy with piperacillin/tazobactam, and isolation in blood cultures of susceptible Yersinia pseudotuberculosis, the patient eventually died. The low prevalence and the ability to mimic other diseases makes difficult to diagnose this entity. The case warns of the absence of response to early treatment with broad-spectrum antibiotic therapy, which questions the possibility of virulence factors yet to be identified, as well as the need to determine which antibiotic is more effective according to clinical severity.
publishDate 2024
dc.date.none.fl_str_mv 2024-02-26
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dc.publisher.none.fl_str_mv Sociedade Portuguesa de Medicina Interna
publisher.none.fl_str_mv Sociedade Portuguesa de Medicina Interna
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dc.identifier.doi.none.fl_str_mv 10.60591/crspmi.41