Effectiveness of antimicrobial interventions directed at tackling antimicrobial resistance in animal production: A systematic review and meta-analysis

Detalhes bibliográficos
Autor(a) principal: Costa, Miguel Mendes
Data de Publicação: 2023
Outros Autores: Cardo, Miguel, Ruano, Zita, Alho, Ana Margarida, Dinis-Teixeira, José, Aguiar, Pedro, Leite, Andreia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/8681
Resumo: Review
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spelling Effectiveness of antimicrobial interventions directed at tackling antimicrobial resistance in animal production: A systematic review and meta-analysisAnimal ProductionAntimicrobial ResistanceAntimicrobial UsageIntervention's EffectivenessProtective EffectsZoonotic BacteriaResistência aos AntimicrobianosBactérias ZoonóticasDeterminantes da Saúde e da DoençaPolíticas de SaúdeSaúde PúblicaReviewBackground: In the last decades, a more prudent and rational use of antimicrobials has been progressively directed towards animal production to reduce antimicrobial selective pressure and antimicrobial resistance (AMR) in microorganisms and safeguard the antimicrobial efficacy of treatments in human medicine. This systematic review evaluated the effectiveness of interventions that have been applied to reduce or improve veterinary antimicrobial usage and aimed at decreasing resistant bacteria in chicken broiler and pig production contexts. Methods: Original articles were identified by searching PubMed™, Scopus™, The Cochrane Library™, and Web of Science™, and grey literature by searching DANS EASY™, WorldCat™ and RCAAP™. Inclusion criteria included: chicken broiler or pig populations (predestined for meat production), interventions intended to reduce/improve antimicrobial use, comparator with standard or no use of antimicrobials, outcomes related to prevalence of resistant bacteria, farm level studies, original data, and analytical observational studies. Data was extracted from eligible studies and meta-analysis using random or fixed effects models was conducted for combinations including type of intervention, bacterial species, production type and animal populations. Models were selected according to heterogeneity between studies. The effectiveness of interventions was assessed using pooled odds ratio of resistance to antimicrobial substances/classes by bacteria for associations between animal populations with and without intervention. Results: A total of 46 studies were eligible for review. For chicken broilers, most interventions were identified as antimicrobial restrictions on all non-therapeutic use (46%), complete restriction (27%), and prohibition on antimicrobials used for growth promotion (23%). As for pig populations, restrictions were mainly observed on all non-therapeutic use (37%), complete restriction (37%) and group treatments (22%). For meta-analysis, 21 studies were pooled after assessment of existing combinations. These combinations demonstrated a protective effect for most antimicrobial classes in Escherichia coli, Campylobacter and Enterococcus isolates from samples of chicken broilers as well in Escherichia coli and Campylobacter spp. from samples of pigs, compared to animals raised under conventional production or without intervention. Increased odds of resistance were only observed for cephalosporins in E. coli and broilers raised without antimicrobials, and to fluoroquinolones and quinolones in Campylobacter and pigs raised without antimicrobials, compared to conventional production. Conclusions: Our study indicates that organic production, antimicrobial-free farms, and group treatment restrictions are recommended for AMR reduction, providing information that may support decision-making to tackle AMR and better reporting to improve comparability of results between studies.ElsevierRepositório Científico do Instituto Nacional de SaúdeCosta, Miguel MendesCardo, MiguelRuano, ZitaAlho, Ana MargaridaDinis-Teixeira, JoséAguiar, PedroLeite, Andreia2023-10-10T13:19:02Z2023-092023-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8681engPrev Vet Med. 2023 Sep:218:106002. doi: 10.1016/j.prevetmed.2023.106002. Epub 2023 Aug 18. Review0167-587710.1016/j.prevetmed.2023.106002info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-14T01:32:17Zoai:repositorio.insa.pt:10400.18/8681Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:35:35.350811Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Effectiveness of antimicrobial interventions directed at tackling antimicrobial resistance in animal production: A systematic review and meta-analysis
title Effectiveness of antimicrobial interventions directed at tackling antimicrobial resistance in animal production: A systematic review and meta-analysis
spellingShingle Effectiveness of antimicrobial interventions directed at tackling antimicrobial resistance in animal production: A systematic review and meta-analysis
Costa, Miguel Mendes
Animal Production
Antimicrobial Resistance
Antimicrobial Usage
Intervention's Effectiveness
Protective Effects
Zoonotic Bacteria
Resistência aos Antimicrobianos
Bactérias Zoonóticas
Determinantes da Saúde e da Doença
Políticas de Saúde
Saúde Pública
title_short Effectiveness of antimicrobial interventions directed at tackling antimicrobial resistance in animal production: A systematic review and meta-analysis
title_full Effectiveness of antimicrobial interventions directed at tackling antimicrobial resistance in animal production: A systematic review and meta-analysis
title_fullStr Effectiveness of antimicrobial interventions directed at tackling antimicrobial resistance in animal production: A systematic review and meta-analysis
title_full_unstemmed Effectiveness of antimicrobial interventions directed at tackling antimicrobial resistance in animal production: A systematic review and meta-analysis
title_sort Effectiveness of antimicrobial interventions directed at tackling antimicrobial resistance in animal production: A systematic review and meta-analysis
author Costa, Miguel Mendes
author_facet Costa, Miguel Mendes
Cardo, Miguel
Ruano, Zita
Alho, Ana Margarida
Dinis-Teixeira, José
Aguiar, Pedro
Leite, Andreia
author_role author
author2 Cardo, Miguel
Ruano, Zita
Alho, Ana Margarida
Dinis-Teixeira, José
Aguiar, Pedro
Leite, Andreia
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Costa, Miguel Mendes
Cardo, Miguel
Ruano, Zita
Alho, Ana Margarida
Dinis-Teixeira, José
Aguiar, Pedro
Leite, Andreia
dc.subject.por.fl_str_mv Animal Production
Antimicrobial Resistance
Antimicrobial Usage
Intervention's Effectiveness
Protective Effects
Zoonotic Bacteria
Resistência aos Antimicrobianos
Bactérias Zoonóticas
Determinantes da Saúde e da Doença
Políticas de Saúde
Saúde Pública
topic Animal Production
Antimicrobial Resistance
Antimicrobial Usage
Intervention's Effectiveness
Protective Effects
Zoonotic Bacteria
Resistência aos Antimicrobianos
Bactérias Zoonóticas
Determinantes da Saúde e da Doença
Políticas de Saúde
Saúde Pública
description Review
publishDate 2023
dc.date.none.fl_str_mv 2023-10-10T13:19:02Z
2023-09
2023-09-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/8681
url http://hdl.handle.net/10400.18/8681
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Prev Vet Med. 2023 Sep:218:106002. doi: 10.1016/j.prevetmed.2023.106002. Epub 2023 Aug 18. Review
0167-5877
10.1016/j.prevetmed.2023.106002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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