Evaluation of the Kinetics of Pancreatic Stone Protein as a Predictor of Ventilator-Associated Pneumonia
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/159822 |
Resumo: | Funding Information: This study was partially supported by Abionic, CIBERES, and Research and Innovation Institute Parc Tauli (I3PT). A.C. acknowledges receiving financial support from Instituto de Salud Carlos III (ISCIII; Sara Borrell 2021: CD21/00087). The funding sources had no role in the design and conduct of the study; the collection, management, analysis, and interpretation of the data; the preparation, review, or approval of the manuscript; or in the decision to submit the manuscript for publication. Publisher Copyright: © 2023 by the authors. |
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oai:run.unl.pt:10362/159822 |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Evaluation of the Kinetics of Pancreatic Stone Protein as a Predictor of Ventilator-Associated Pneumoniabiomarkerspancreatic stone proteinpredictionventilator-associated pneumoniaMedicine (miscellaneous)Biochemistry, Genetics and Molecular Biology(all)Funding Information: This study was partially supported by Abionic, CIBERES, and Research and Innovation Institute Parc Tauli (I3PT). A.C. acknowledges receiving financial support from Instituto de Salud Carlos III (ISCIII; Sara Borrell 2021: CD21/00087). The funding sources had no role in the design and conduct of the study; the collection, management, analysis, and interpretation of the data; the preparation, review, or approval of the manuscript; or in the decision to submit the manuscript for publication. Publisher Copyright: © 2023 by the authors.BACKGROUND: Ventilator-associated pneumonia (VAP) is a severe condition. Early and adequate antibiotic treatment is the most important strategy for improving prognosis. Pancreatic Stone Protein (PSP) has been described as a biomarker that increases values 3–4 days before the clinical diagnosis of nosocomial sepsis in different clinical settings. We hypothesized that serial measures of PSP and its kinetics allow for an early diagnosis of VAP. METHODS: The BioVAP study was a prospective observational study designed to evaluate the role of biomarker dynamics in the diagnosis of VAP. To determine the association between repeatedly measured PSP and the risk of VAP, we used joint models for longitudinal and time-to-event data. RESULTS: Of 209 patients, 43 (20.6%) patients developed VAP, with a median time of 4 days. Multivariate joint models with PSP, CRP, and PCT did not show an association between biomarkers and VAP for the daily absolute value, with a hazard ratio (HR) for PSP of 1.01 (95% credible interval: 0.97 to 1.05), for CRP of 1.00 (0.83 to 1.22), and for PCT of 0.95 (0.82 to 1.08). The daily change of biomarkers provided similar results, with an HR for PSP of 1.15 (0.94 to 1.41), for CRP of 0.76 (0.35 to 1.58), and for PCT of 0.77 (0.40 to 1.45). CONCLUSION: Neither absolute PSP values nor PSP kinetics alone nor in combination with other biomarkers were useful in improving the prediction diagnosis accuracy in patients with VAP. Clinical Trial Registration: Registered retrospectively on August 3rd, 2012. NCT02078999.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNCeccato, AdrianCamprubí-Rimblas, MartaBos, Lieuwe D.J.Povoa, PedroMartin-Loeches, IgnacioForné, CarlesAreny-Balagueró, AinaCampaña-Duel, ElenaMorales-Quinteros, LuisQuero, SaraRamirez, PaulaEsperatti, MarianoTorres, AntoniBlanch, LluisArtigas, Antonio2023-11-10T22:10:25Z2023-102023-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/159822eng2227-9059PURE: 75814751https://doi.org/10.3390/biomedicines11102676info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:15:36Zoai:run.unl.pt:10362/159822Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:15:36Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Evaluation of the Kinetics of Pancreatic Stone Protein as a Predictor of Ventilator-Associated Pneumonia |
| title |
Evaluation of the Kinetics of Pancreatic Stone Protein as a Predictor of Ventilator-Associated Pneumonia |
| spellingShingle |
Evaluation of the Kinetics of Pancreatic Stone Protein as a Predictor of Ventilator-Associated Pneumonia Ceccato, Adrian biomarkers pancreatic stone protein prediction ventilator-associated pneumonia Medicine (miscellaneous) Biochemistry, Genetics and Molecular Biology(all) |
| title_short |
Evaluation of the Kinetics of Pancreatic Stone Protein as a Predictor of Ventilator-Associated Pneumonia |
| title_full |
Evaluation of the Kinetics of Pancreatic Stone Protein as a Predictor of Ventilator-Associated Pneumonia |
| title_fullStr |
Evaluation of the Kinetics of Pancreatic Stone Protein as a Predictor of Ventilator-Associated Pneumonia |
| title_full_unstemmed |
Evaluation of the Kinetics of Pancreatic Stone Protein as a Predictor of Ventilator-Associated Pneumonia |
| title_sort |
Evaluation of the Kinetics of Pancreatic Stone Protein as a Predictor of Ventilator-Associated Pneumonia |
| author |
Ceccato, Adrian |
| author_facet |
Ceccato, Adrian Camprubí-Rimblas, Marta Bos, Lieuwe D.J. Povoa, Pedro Martin-Loeches, Ignacio Forné, Carles Areny-Balagueró, Aina Campaña-Duel, Elena Morales-Quinteros, Luis Quero, Sara Ramirez, Paula Esperatti, Mariano Torres, Antoni Blanch, Lluis Artigas, Antonio |
| author_role |
author |
| author2 |
Camprubí-Rimblas, Marta Bos, Lieuwe D.J. Povoa, Pedro Martin-Loeches, Ignacio Forné, Carles Areny-Balagueró, Aina Campaña-Duel, Elena Morales-Quinteros, Luis Quero, Sara Ramirez, Paula Esperatti, Mariano Torres, Antoni Blanch, Lluis Artigas, Antonio |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Ceccato, Adrian Camprubí-Rimblas, Marta Bos, Lieuwe D.J. Povoa, Pedro Martin-Loeches, Ignacio Forné, Carles Areny-Balagueró, Aina Campaña-Duel, Elena Morales-Quinteros, Luis Quero, Sara Ramirez, Paula Esperatti, Mariano Torres, Antoni Blanch, Lluis Artigas, Antonio |
| dc.subject.por.fl_str_mv |
biomarkers pancreatic stone protein prediction ventilator-associated pneumonia Medicine (miscellaneous) Biochemistry, Genetics and Molecular Biology(all) |
| topic |
biomarkers pancreatic stone protein prediction ventilator-associated pneumonia Medicine (miscellaneous) Biochemistry, Genetics and Molecular Biology(all) |
| description |
Funding Information: This study was partially supported by Abionic, CIBERES, and Research and Innovation Institute Parc Tauli (I3PT). A.C. acknowledges receiving financial support from Instituto de Salud Carlos III (ISCIII; Sara Borrell 2021: CD21/00087). The funding sources had no role in the design and conduct of the study; the collection, management, analysis, and interpretation of the data; the preparation, review, or approval of the manuscript; or in the decision to submit the manuscript for publication. Publisher Copyright: © 2023 by the authors. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-11-10T22:10:25Z 2023-10 2023-10-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
| format |
article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/159822 |
| url |
http://hdl.handle.net/10362/159822 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2227-9059 PURE: 75814751 https://doi.org/10.3390/biomedicines11102676 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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mluisa.alvim@gmail.com |
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1817545965486211072 |