Influence of HER2 expression on prognosis in metastatic triple-negative breast cancer—results from an international, multicenter analysis coordinated by the AGMT Study Group
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/147551 |
Resumo: | Funding Information: This project was initiated at the Endeavour Breast Project coordinated by Daiichi Sankyo (special thanks to Christian Opitz and Britta Mazur from Daiichi Sankyo). We thank all participants and the steering committee members of the Endeavour Breast Meeting who are not listed as co-authors ( Supplementary Table S4 , available at https://doi.org/10.1016/j.esmoop.2022.100747 ). The authors gratefully acknowledge the support from the AGMT office (particularly Mag. Katrin Dorfinger, Mag. Alexandra Keuschnig, Sebastian Schütz, and Dr. Daniela Wolkersdorfer) and all trial coordinators at the contributing centers. Publisher Copyright: © 2022 The Authors |
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Influence of HER2 expression on prognosis in metastatic triple-negative breast cancer—results from an international, multicenter analysis coordinated by the AGMT Study GroupHER2-lowmetastaticOSprognosisreal-world datatriple-negative breast cancerOncologyCancer ResearchSDG 3 - Good Health and Well-beingFunding Information: This project was initiated at the Endeavour Breast Project coordinated by Daiichi Sankyo (special thanks to Christian Opitz and Britta Mazur from Daiichi Sankyo). We thank all participants and the steering committee members of the Endeavour Breast Meeting who are not listed as co-authors ( Supplementary Table S4 , available at https://doi.org/10.1016/j.esmoop.2022.100747 ). The authors gratefully acknowledge the support from the AGMT office (particularly Mag. Katrin Dorfinger, Mag. Alexandra Keuschnig, Sebastian Schütz, and Dr. Daniela Wolkersdorfer) and all trial coordinators at the contributing centers. Publisher Copyright: © 2022 The AuthorsBackground: Triple-negative breast cancer (TNBC) is associated with poor prognosis, and new treatment options are urgently needed. About 34%-39% of primary TNBCs show a low expression of human epidermal growth factor receptor 2 (HER2-low), which is a target for new anti-HER2 drugs. However, little is known about the frequency and the prognostic value of HER2-low in metastatic TNBC. Patients and methods: We retrospectively included patients with TNBC from five European countries for this international, multicenter analysis. Triple-negativity had to be shown in a metastatic site or in the primary breast tumor diagnosed simultaneously or within 3 years before metastatic disease. HER2-low was defined as immunohistochemically (IHC) 1+ or 2+ without ERBB2 gene amplification. Survival probabilities were calculated by the Kaplan–Meier method, and multivariable hazard ratios (HRs) were estimated by Cox regression models. Results: In total, 691 patients, diagnosed between January 2006 and February 2021, were assessable. The incidence of HER2-low was 32.0% [95% confidence interval (CI) 28.5% to 35.5%], with similar proportions in metastases (n = 265; 29.8%) and primary tumors (n = 425; 33.4%; P = 0.324). The median overall survival (OS) in HER2-low and HER2-0 TNBC was 18.6 and 16.1 months, respectively (HR 1.00; 95% CI 0.83-1.19; P = 0.969). Similarly, in multivariable analysis, HER2-low had no significant impact on OS (HR 0.95; 95% CI 0.79-1.13; P = 0.545). No difference in prognosis was observed between HER2 IHC 0/1+ and IHC 2+ tumors (HR 0.89; 95% CI 0.69-1.17; P = 0.414). Conclusions: In this large international dataset of metastatic TNBC, the frequency of HER2-low was 32.0%. Neither in univariable nor in multivariable analysis HER2-low showed any influence on OS.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNGampenrieder, S. P.Dezentjé, V.Lambertini, M.de Nonneville, A.Marhold, M.Le Du, F.Cortés Salgado, A.Alpuim Costa, D.Vaz Batista, M.Chic Ruché, N.Tinchon, C.Petzer, A.Blondeaux, E.Del Mastro, L.Targato, G.Bertucci, F.Gonçalves, A.Viret, F.Bartsch, R.Mannsbart, C.Deleuze, A.Robert, L.Saavedra Serrano, C.Gion Cortés, M.Sampaio-Alves, M.Vitorino, M.Pecen, L.Singer, C.Harbeck, N.Rinnerthaler, G.Greil, R.2023-01-13T22:20:10Z2023-022023-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/147551eng2059-7029PURE: 49448338https://doi.org/10.1016/j.esmoop.2022.100747info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:08:09Zoai:run.unl.pt:10362/147551Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:08:09Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Influence of HER2 expression on prognosis in metastatic triple-negative breast cancer—results from an international, multicenter analysis coordinated by the AGMT Study Group |
title |
Influence of HER2 expression on prognosis in metastatic triple-negative breast cancer—results from an international, multicenter analysis coordinated by the AGMT Study Group |
spellingShingle |
Influence of HER2 expression on prognosis in metastatic triple-negative breast cancer—results from an international, multicenter analysis coordinated by the AGMT Study Group Gampenrieder, S. P. HER2-low metastatic OS prognosis real-world data triple-negative breast cancer Oncology Cancer Research SDG 3 - Good Health and Well-being |
title_short |
Influence of HER2 expression on prognosis in metastatic triple-negative breast cancer—results from an international, multicenter analysis coordinated by the AGMT Study Group |
title_full |
Influence of HER2 expression on prognosis in metastatic triple-negative breast cancer—results from an international, multicenter analysis coordinated by the AGMT Study Group |
title_fullStr |
Influence of HER2 expression on prognosis in metastatic triple-negative breast cancer—results from an international, multicenter analysis coordinated by the AGMT Study Group |
title_full_unstemmed |
Influence of HER2 expression on prognosis in metastatic triple-negative breast cancer—results from an international, multicenter analysis coordinated by the AGMT Study Group |
title_sort |
Influence of HER2 expression on prognosis in metastatic triple-negative breast cancer—results from an international, multicenter analysis coordinated by the AGMT Study Group |
author |
Gampenrieder, S. P. |
author_facet |
Gampenrieder, S. P. Dezentjé, V. Lambertini, M. de Nonneville, A. Marhold, M. Le Du, F. Cortés Salgado, A. Alpuim Costa, D. Vaz Batista, M. Chic Ruché, N. Tinchon, C. Petzer, A. Blondeaux, E. Del Mastro, L. Targato, G. Bertucci, F. Gonçalves, A. Viret, F. Bartsch, R. Mannsbart, C. Deleuze, A. Robert, L. Saavedra Serrano, C. Gion Cortés, M. Sampaio-Alves, M. Vitorino, M. Pecen, L. Singer, C. Harbeck, N. Rinnerthaler, G. Greil, R. |
author_role |
author |
author2 |
Dezentjé, V. Lambertini, M. de Nonneville, A. Marhold, M. Le Du, F. Cortés Salgado, A. Alpuim Costa, D. Vaz Batista, M. Chic Ruché, N. Tinchon, C. Petzer, A. Blondeaux, E. Del Mastro, L. Targato, G. Bertucci, F. Gonçalves, A. Viret, F. Bartsch, R. Mannsbart, C. Deleuze, A. Robert, L. Saavedra Serrano, C. Gion Cortés, M. Sampaio-Alves, M. Vitorino, M. Pecen, L. Singer, C. Harbeck, N. Rinnerthaler, G. Greil, R. |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Gampenrieder, S. P. Dezentjé, V. Lambertini, M. de Nonneville, A. Marhold, M. Le Du, F. Cortés Salgado, A. Alpuim Costa, D. Vaz Batista, M. Chic Ruché, N. Tinchon, C. Petzer, A. Blondeaux, E. Del Mastro, L. Targato, G. Bertucci, F. Gonçalves, A. Viret, F. Bartsch, R. Mannsbart, C. Deleuze, A. Robert, L. Saavedra Serrano, C. Gion Cortés, M. Sampaio-Alves, M. Vitorino, M. Pecen, L. Singer, C. Harbeck, N. Rinnerthaler, G. Greil, R. |
dc.subject.por.fl_str_mv |
HER2-low metastatic OS prognosis real-world data triple-negative breast cancer Oncology Cancer Research SDG 3 - Good Health and Well-being |
topic |
HER2-low metastatic OS prognosis real-world data triple-negative breast cancer Oncology Cancer Research SDG 3 - Good Health and Well-being |
description |
Funding Information: This project was initiated at the Endeavour Breast Project coordinated by Daiichi Sankyo (special thanks to Christian Opitz and Britta Mazur from Daiichi Sankyo). We thank all participants and the steering committee members of the Endeavour Breast Meeting who are not listed as co-authors ( Supplementary Table S4 , available at https://doi.org/10.1016/j.esmoop.2022.100747 ). The authors gratefully acknowledge the support from the AGMT office (particularly Mag. Katrin Dorfinger, Mag. Alexandra Keuschnig, Sebastian Schütz, and Dr. Daniela Wolkersdorfer) and all trial coordinators at the contributing centers. Publisher Copyright: © 2022 The Authors |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-01-13T22:20:10Z 2023-02 2023-02-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/147551 |
url |
http://hdl.handle.net/10362/147551 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2059-7029 PURE: 49448338 https://doi.org/10.1016/j.esmoop.2022.100747 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1817545909302460416 |