Towards a nanospecific approach for risk assessment.
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/4465 |
Resumo: | In the current paper, a new strategy for risk assessment of nanomaterials is described, which builds upon previous project outcomes and is developed within the FP7 NANoREG project. NANoREG has the aim to develop, for the long term, new testing strategies adapted to a high number of nanomaterials where many factors can affect their environmental and health impact. In the proposed risk assessment strategy, approaches for (Quantitative) Structure Activity Relationships ((Q)SARs), grouping and read-across are integrated and expanded to guide the user how to prioritise those nanomaterial applications that may lead to high risks for human health. Furthermore, those aspects of exposure, kinetics and hazard assessment that are most likely to be influenced by the nanospecific properties of the material under assessment are identified. These aspects are summarised in six elements, which play a key role in the strategy: exposure potential, dissolution, nanomaterial transformation, accumulation, genotoxicity and immunotoxicity. With the current approach it is possible to identify those situations where the use of nanospecific grouping, read-across and (Q)SAR tools is likely to become feasible in the future, and to point towards the generation of the type of data that is needed for scientific justification, which may lead to regulatory acceptance of nanospecific applications of these tools. |
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Towards a nanospecific approach for risk assessment.NanomaterialsRisk Assessment ApproachTesting Strategy(Q)SARsGroupingPrioritisationRead-acrossGenotoxicidade AmbientalIn the current paper, a new strategy for risk assessment of nanomaterials is described, which builds upon previous project outcomes and is developed within the FP7 NANoREG project. NANoREG has the aim to develop, for the long term, new testing strategies adapted to a high number of nanomaterials where many factors can affect their environmental and health impact. In the proposed risk assessment strategy, approaches for (Quantitative) Structure Activity Relationships ((Q)SARs), grouping and read-across are integrated and expanded to guide the user how to prioritise those nanomaterial applications that may lead to high risks for human health. Furthermore, those aspects of exposure, kinetics and hazard assessment that are most likely to be influenced by the nanospecific properties of the material under assessment are identified. These aspects are summarised in six elements, which play a key role in the strategy: exposure potential, dissolution, nanomaterial transformation, accumulation, genotoxicity and immunotoxicity. With the current approach it is possible to identify those situations where the use of nanospecific grouping, read-across and (Q)SAR tools is likely to become feasible in the future, and to point towards the generation of the type of data that is needed for scientific justification, which may lead to regulatory acceptance of nanospecific applications of these tools.The research leading to these results has been partially funded by the European Union Seventh Framework Programme (FP7/ 2007e2013) under the project NANoREG (A common European approach to the regulatory testing of nanomaterials), grant agreement 310584.ElsevierRepositório Científico do Instituto Nacional de SaúdeDekkers, S.Oomen, A.G.Bleeker, E.A.Vandebriel, RJ..Micheletti, C.Cabellos, J.Janer, G.Fuentes, N.Vázquez-Campos, S.Borges, T.Silva, M.J.Prina-Mello, A.Movia, D.Nesslany, F.Ribeiro, A.R.Leite, P.E.Groenewold, M.Cassee, F.R.Sips, A.J.Dijkzeul, A.van Teunenbroek, T.Wijnhoven, S.W.2017-03-03T17:52:45Z2016-102016-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/4465engRegul Toxicol Pharmacol. 2016 Oct;80:46-59. doi: 10.1016/j.yrtph.2016.05.037. Epub 2016 May 300273-23000.1016/j.yrtph.2016.05.037info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:22Zoai:repositorio.insa.pt:10400.18/4465Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:39:17.299771Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Towards a nanospecific approach for risk assessment. |
title |
Towards a nanospecific approach for risk assessment. |
spellingShingle |
Towards a nanospecific approach for risk assessment. Dekkers, S. Nanomaterials Risk Assessment Approach Testing Strategy (Q)SARs Grouping Prioritisation Read-across Genotoxicidade Ambiental |
title_short |
Towards a nanospecific approach for risk assessment. |
title_full |
Towards a nanospecific approach for risk assessment. |
title_fullStr |
Towards a nanospecific approach for risk assessment. |
title_full_unstemmed |
Towards a nanospecific approach for risk assessment. |
title_sort |
Towards a nanospecific approach for risk assessment. |
author |
Dekkers, S. |
author_facet |
Dekkers, S. Oomen, A.G. Bleeker, E.A. Vandebriel, RJ.. Micheletti, C. Cabellos, J. Janer, G. Fuentes, N. Vázquez-Campos, S. Borges, T. Silva, M.J. Prina-Mello, A. Movia, D. Nesslany, F. Ribeiro, A.R. Leite, P.E. Groenewold, M. Cassee, F.R. Sips, A.J. Dijkzeul, A. van Teunenbroek, T. Wijnhoven, S.W. |
author_role |
author |
author2 |
Oomen, A.G. Bleeker, E.A. Vandebriel, RJ.. Micheletti, C. Cabellos, J. Janer, G. Fuentes, N. Vázquez-Campos, S. Borges, T. Silva, M.J. Prina-Mello, A. Movia, D. Nesslany, F. Ribeiro, A.R. Leite, P.E. Groenewold, M. Cassee, F.R. Sips, A.J. Dijkzeul, A. van Teunenbroek, T. Wijnhoven, S.W. |
author2_role |
author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Dekkers, S. Oomen, A.G. Bleeker, E.A. Vandebriel, RJ.. Micheletti, C. Cabellos, J. Janer, G. Fuentes, N. Vázquez-Campos, S. Borges, T. Silva, M.J. Prina-Mello, A. Movia, D. Nesslany, F. Ribeiro, A.R. Leite, P.E. Groenewold, M. Cassee, F.R. Sips, A.J. Dijkzeul, A. van Teunenbroek, T. Wijnhoven, S.W. |
dc.subject.por.fl_str_mv |
Nanomaterials Risk Assessment Approach Testing Strategy (Q)SARs Grouping Prioritisation Read-across Genotoxicidade Ambiental |
topic |
Nanomaterials Risk Assessment Approach Testing Strategy (Q)SARs Grouping Prioritisation Read-across Genotoxicidade Ambiental |
description |
In the current paper, a new strategy for risk assessment of nanomaterials is described, which builds upon previous project outcomes and is developed within the FP7 NANoREG project. NANoREG has the aim to develop, for the long term, new testing strategies adapted to a high number of nanomaterials where many factors can affect their environmental and health impact. In the proposed risk assessment strategy, approaches for (Quantitative) Structure Activity Relationships ((Q)SARs), grouping and read-across are integrated and expanded to guide the user how to prioritise those nanomaterial applications that may lead to high risks for human health. Furthermore, those aspects of exposure, kinetics and hazard assessment that are most likely to be influenced by the nanospecific properties of the material under assessment are identified. These aspects are summarised in six elements, which play a key role in the strategy: exposure potential, dissolution, nanomaterial transformation, accumulation, genotoxicity and immunotoxicity. With the current approach it is possible to identify those situations where the use of nanospecific grouping, read-across and (Q)SAR tools is likely to become feasible in the future, and to point towards the generation of the type of data that is needed for scientific justification, which may lead to regulatory acceptance of nanospecific applications of these tools. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-10 2016-10-01T00:00:00Z 2017-03-03T17:52:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/4465 |
url |
http://hdl.handle.net/10400.18/4465 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Regul Toxicol Pharmacol. 2016 Oct;80:46-59. doi: 10.1016/j.yrtph.2016.05.037. Epub 2016 May 30 0273-2300 0.1016/j.yrtph.2016.05.037 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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