Proteomics-Driven Biomarkers in Pancreatic Cancer

Detalhes bibliográficos
Autor(a) principal: Ramalhete, Luís
Data de Publicação: 2023
Outros Autores: Vigia, Emanuel, Araújo, Rúben, Pinto Marques, Hugo
Tipo de documento: Outros
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/158794
Resumo: Publisher Copyright: © 2023 by the authors.
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spelling Proteomics-Driven Biomarkers in Pancreatic Cancerbiomarkerchemotherapy effectivenesspancreatic cancerproteomicsStructural BiologyBiochemistryMolecular BiologyClinical BiochemistrySDG 3 - Good Health and Well-beingPublisher Copyright: © 2023 by the authors.Pancreatic cancer is a devastating disease that has a grim prognosis, highlighting the need for improved screening, diagnosis, and treatment strategies. Currently, the sole biomarker for pancreatic ductal adenocarcinoma (PDAC) authorized by the U.S. Food and Drug Administration is CA 19-9, which proves to be the most beneficial in tracking treatment response rather than in early detection. In recent years, proteomics has emerged as a powerful tool for advancing our understanding of pancreatic cancer biology and identifying potential biomarkers and therapeutic targets. This review aims to offer a comprehensive survey of proteomics’ current status in pancreatic cancer research, specifically accentuating its applications and its potential to drastically enhance screening, diagnosis, and treatment response. With respect to screening and diagnostic precision, proteomics carries the capacity to augment the sensitivity and specificity of extant screening and diagnostic methodologies. Nonetheless, more research is imperative for validating potential biomarkers and establishing standard procedures for sample preparation and data analysis. Furthermore, proteomics presents opportunities for unveiling new biomarkers and therapeutic targets, as well as fostering the development of personalized treatment strategies based on protein expression patterns associated with treatment response. In conclusion, proteomics holds great promise for advancing our understanding of pancreatic cancer biology and improving patient outcomes. It is essential to maintain momentum in investment and innovation in this arena to unearth more groundbreaking discoveries and transmute them into practical diagnostic and therapeutic strategies in the clinical context.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)iNOVA4Health - pólo NMSComprehensive Health Research Centre (CHRC) - pólo NMSRUNRamalhete, LuísVigia, EmanuelAraújo, RúbenPinto Marques, Hugo2023-10-09T22:18:37Z2023-092023-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/158794eng2227-7382PURE: 73492450https://doi.org/10.3390/proteomes11030024info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:14:59Zoai:run.unl.pt:10362/158794Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:14:59Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Proteomics-Driven Biomarkers in Pancreatic Cancer
title Proteomics-Driven Biomarkers in Pancreatic Cancer
spellingShingle Proteomics-Driven Biomarkers in Pancreatic Cancer
Ramalhete, Luís
biomarker
chemotherapy effectiveness
pancreatic cancer
proteomics
Structural Biology
Biochemistry
Molecular Biology
Clinical Biochemistry
SDG 3 - Good Health and Well-being
title_short Proteomics-Driven Biomarkers in Pancreatic Cancer
title_full Proteomics-Driven Biomarkers in Pancreatic Cancer
title_fullStr Proteomics-Driven Biomarkers in Pancreatic Cancer
title_full_unstemmed Proteomics-Driven Biomarkers in Pancreatic Cancer
title_sort Proteomics-Driven Biomarkers in Pancreatic Cancer
author Ramalhete, Luís
author_facet Ramalhete, Luís
Vigia, Emanuel
Araújo, Rúben
Pinto Marques, Hugo
author_role author
author2 Vigia, Emanuel
Araújo, Rúben
Pinto Marques, Hugo
author2_role author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
iNOVA4Health - pólo NMS
Comprehensive Health Research Centre (CHRC) - pólo NMS
RUN
dc.contributor.author.fl_str_mv Ramalhete, Luís
Vigia, Emanuel
Araújo, Rúben
Pinto Marques, Hugo
dc.subject.por.fl_str_mv biomarker
chemotherapy effectiveness
pancreatic cancer
proteomics
Structural Biology
Biochemistry
Molecular Biology
Clinical Biochemistry
SDG 3 - Good Health and Well-being
topic biomarker
chemotherapy effectiveness
pancreatic cancer
proteomics
Structural Biology
Biochemistry
Molecular Biology
Clinical Biochemistry
SDG 3 - Good Health and Well-being
description Publisher Copyright: © 2023 by the authors.
publishDate 2023
dc.date.none.fl_str_mv 2023-10-09T22:18:37Z
2023-09
2023-09-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/158794
url http://hdl.handle.net/10362/158794
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2227-7382
PURE: 73492450
https://doi.org/10.3390/proteomes11030024
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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