Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes’ repertoires
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/162817 |
Resumo: | Funding Information: The present work was submitted by C.S.M. as partial fulfillment of a Ph.D. degree at the Faculty of Biology and Medicine of the University of Lausanne. Sequencing was performed at the Lausanne Genomic Technologies Facility, University of Lausanne. We thank Patrick Taffé (Unisanté, Division of Biostatistics, University of Lausanne) for input into the simulation experiments. This work was supported by Swiss National Science Foundation grant 310030_192802 to P.M.H. The Swiss National Science Foundation had no role in any steps of the study. M.T.C. is a Senior Research Career Scientist supported by IK6BX005232 Department of Veterans Affairs. All materials are available from the corresponding author. Funding Information: The present work was submitted by C.S.M. as partial fulfillment of a Ph.D. degree at the Faculty of Biology and Medicine of the University of Lausanne. Sequencing was performed at the Lausanne Genomic Technologies Facility, University of Lausanne. We thank Patrick Taffé (Unisanté, Division of Biostatistics, University of Lausanne) for input into the simulation experiments. This work was supported by Swiss National Science Foundation grant 310030_192802 to P.M.H. The Swiss National Science Foundation had no role in any steps of the study. M.T.C. is a Senior Research Career Scientist supported by IK6BX005232 Department of Veterans Affairs. All materials are available from the corresponding author. Publisher Copyright: © 2023, The Author(s). |
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Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes’ repertoiresChemistry(all)Biochemistry, Genetics and Molecular Biology(all)Physics and Astronomy(all)SDG 3 - Good Health and Well-beingFunding Information: The present work was submitted by C.S.M. as partial fulfillment of a Ph.D. degree at the Faculty of Biology and Medicine of the University of Lausanne. Sequencing was performed at the Lausanne Genomic Technologies Facility, University of Lausanne. We thank Patrick Taffé (Unisanté, Division of Biostatistics, University of Lausanne) for input into the simulation experiments. This work was supported by Swiss National Science Foundation grant 310030_192802 to P.M.H. The Swiss National Science Foundation had no role in any steps of the study. M.T.C. is a Senior Research Career Scientist supported by IK6BX005232 Department of Veterans Affairs. All materials are available from the corresponding author. Funding Information: The present work was submitted by C.S.M. as partial fulfillment of a Ph.D. degree at the Faculty of Biology and Medicine of the University of Lausanne. Sequencing was performed at the Lausanne Genomic Technologies Facility, University of Lausanne. We thank Patrick Taffé (Unisanté, Division of Biostatistics, University of Lausanne) for input into the simulation experiments. This work was supported by Swiss National Science Foundation grant 310030_192802 to P.M.H. The Swiss National Science Foundation had no role in any steps of the study. M.T.C. is a Senior Research Career Scientist supported by IK6BX005232 Department of Veterans Affairs. All materials are available from the corresponding author. Publisher Copyright: © 2023, The Author(s).Surface antigenic variation is crucial for major pathogens that infect humans. To escape the immune system, they exploit various mechanisms. Understanding these mechanisms is important to better prevent and fight the deadly diseases caused. Those used by the fungus Pneumocystis jirovecii that causes life-threatening pneumonia in immunocompromised individuals remain poorly understood. Here, though this fungus is currently not cultivable, our detailed analysis of the subtelomeric sequence motifs and genes encoding surface proteins suggests that the system involves the reassortment of the repertoire of ca. 80 non-expressed genes present in each strain, from which single genes are retrieved for mutually exclusive expression. Dispersion of the new repertoires, supposedly by healthy carrier individuals, appears very efficient because identical alleles are observed in patients from different countries. Our observations reveal a unique strategy of antigenic variation. They also highlight the possible role in genome rearrangements of small imperfect mirror sequences forming DNA triplexes.UCIBIO - Applied Molecular Biosciences UnitDCV - Departamento de Ciências da VidaRUNMeier, Caroline S.Pagni, MarcoRichard, SophieMühlethaler, KonradAlmeida, João M. G. C. F.Nevez, GillesCushion, Melanie T.Calderón, Enrique J.Hauser, Philippe M.2024-01-27T03:59:11Z2023-122023-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article15application/pdfhttp://hdl.handle.net/10362/162817eng2041-1723PURE: 81716373https://doi.org/10.1038/s41467-023-42685-6info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:45:50Zoai:run.unl.pt:10362/162817Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:59:06.476612Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes’ repertoires |
title |
Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes’ repertoires |
spellingShingle |
Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes’ repertoires Meier, Caroline S. Chemistry(all) Biochemistry, Genetics and Molecular Biology(all) Physics and Astronomy(all) SDG 3 - Good Health and Well-being |
title_short |
Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes’ repertoires |
title_full |
Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes’ repertoires |
title_fullStr |
Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes’ repertoires |
title_full_unstemmed |
Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes’ repertoires |
title_sort |
Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes’ repertoires |
author |
Meier, Caroline S. |
author_facet |
Meier, Caroline S. Pagni, Marco Richard, Sophie Mühlethaler, Konrad Almeida, João M. G. C. F. Nevez, Gilles Cushion, Melanie T. Calderón, Enrique J. Hauser, Philippe M. |
author_role |
author |
author2 |
Pagni, Marco Richard, Sophie Mühlethaler, Konrad Almeida, João M. G. C. F. Nevez, Gilles Cushion, Melanie T. Calderón, Enrique J. Hauser, Philippe M. |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
UCIBIO - Applied Molecular Biosciences Unit DCV - Departamento de Ciências da Vida RUN |
dc.contributor.author.fl_str_mv |
Meier, Caroline S. Pagni, Marco Richard, Sophie Mühlethaler, Konrad Almeida, João M. G. C. F. Nevez, Gilles Cushion, Melanie T. Calderón, Enrique J. Hauser, Philippe M. |
dc.subject.por.fl_str_mv |
Chemistry(all) Biochemistry, Genetics and Molecular Biology(all) Physics and Astronomy(all) SDG 3 - Good Health and Well-being |
topic |
Chemistry(all) Biochemistry, Genetics and Molecular Biology(all) Physics and Astronomy(all) SDG 3 - Good Health and Well-being |
description |
Funding Information: The present work was submitted by C.S.M. as partial fulfillment of a Ph.D. degree at the Faculty of Biology and Medicine of the University of Lausanne. Sequencing was performed at the Lausanne Genomic Technologies Facility, University of Lausanne. We thank Patrick Taffé (Unisanté, Division of Biostatistics, University of Lausanne) for input into the simulation experiments. This work was supported by Swiss National Science Foundation grant 310030_192802 to P.M.H. The Swiss National Science Foundation had no role in any steps of the study. M.T.C. is a Senior Research Career Scientist supported by IK6BX005232 Department of Veterans Affairs. All materials are available from the corresponding author. Funding Information: The present work was submitted by C.S.M. as partial fulfillment of a Ph.D. degree at the Faculty of Biology and Medicine of the University of Lausanne. Sequencing was performed at the Lausanne Genomic Technologies Facility, University of Lausanne. We thank Patrick Taffé (Unisanté, Division of Biostatistics, University of Lausanne) for input into the simulation experiments. This work was supported by Swiss National Science Foundation grant 310030_192802 to P.M.H. The Swiss National Science Foundation had no role in any steps of the study. M.T.C. is a Senior Research Career Scientist supported by IK6BX005232 Department of Veterans Affairs. All materials are available from the corresponding author. Publisher Copyright: © 2023, The Author(s). |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-12 2023-12-01T00:00:00Z 2024-01-27T03:59:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/162817 |
url |
http://hdl.handle.net/10362/162817 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2041-1723 PURE: 81716373 https://doi.org/10.1038/s41467-023-42685-6 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
15 application/pdf |
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