Therapeutic Approach of Peritoneal Carcinomatosis in patients with Colorectal Carcinoma

Detalhes bibliográficos
Autor(a) principal: Mosca, Ana Margarida Saraiva Santos
Data de Publicação: 2017
Outros Autores: Barbosa, Laura Elisabete
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://revista.spcir.com/index.php/spcir/article/view/443
Resumo: Peritoneal carcinomatosis is an advanced stage of colorectal cancer, with poor prognosis, that has been regarded as an untreatable condition, suitable only for palliative treatment. Over the last decades new treatment options have emerged; cytoreductive surgery in combination with intraperitoneal chemotherapy has increasingly gain acceptance as a treatment for patients with colorectal peritoneal carcinomatosis. Recent clinical studies have suggested that this new approach could result in long-term survival in selected patients. The emerging trend is to regard peritoneal carcinomatosis as a regional metastatic disease, suitable to locoregional treatment. However a successful outcome depends on an appropriate selection of patients: patients with limited peritoneal disease, where complete cytoreduction is achieved have a greater benefit with this new therapeutic strategy. This review sumarizes indications, technical aspects, limitations, outcomes and challenges of this new approach in the treatment of colorectal peritoneal carcinomatosis.
id RCAP_87170a60e5b848208a0e8d9b006cc5b5
oai_identifier_str oai:revista.spcir.com:article/443
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Therapeutic Approach of Peritoneal Carcinomatosis in patients with Colorectal CarcinomaAbordagem Terapêutica da Carcinomatose Peritoneal em doentes com Carcinoma ColorretalPeritoneal carcinomatosis is an advanced stage of colorectal cancer, with poor prognosis, that has been regarded as an untreatable condition, suitable only for palliative treatment. Over the last decades new treatment options have emerged; cytoreductive surgery in combination with intraperitoneal chemotherapy has increasingly gain acceptance as a treatment for patients with colorectal peritoneal carcinomatosis. Recent clinical studies have suggested that this new approach could result in long-term survival in selected patients. The emerging trend is to regard peritoneal carcinomatosis as a regional metastatic disease, suitable to locoregional treatment. However a successful outcome depends on an appropriate selection of patients: patients with limited peritoneal disease, where complete cytoreduction is achieved have a greater benefit with this new therapeutic strategy. This review sumarizes indications, technical aspects, limitations, outcomes and challenges of this new approach in the treatment of colorectal peritoneal carcinomatosis.A carcinomatose peritoneal (CP) é uma fase avançada da evolução do carcinoma colorretal que está associada a um mau prognóstico. A CP era compreendida como uma doença incurável, o tratamento consistia numa abordagem meramente paliativa. Durante as últimas décadas sugiram novas opções terapêuticas; a cirurgia citorredutora combinada com a quimioterapia intraperitoneal foi proposta como possibilidade terapêutica em doentes com carcinomatose peritoneal com origem no carcinoma colorretal (CCR). Estudos recentes defendem que esta nova abordagem pode promover um aumento da sobrevida em doentes selecionados. O conceito consiste em interpretar a CP como uma metastização regional da doença, suscetível a tratamento locorregional. Contudo, o resultado obtido depende da seleção adequada dos doentes submetidos a esta abordagem terapêutica: doentes com doença peritoneal limitada em que se verifica uma citorredução completa, apresentam benefício. Nesta revisão serão discutidas as indicações, os aspetos técnicos, as limitações, os resultados obtidos e os desafios desta nova abordagem terapêutica nos doentes com carcinomatose peritoneal com origem no CCR.Sociedade Portuguesa de Cirurgia2017-03-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://revista.spcir.com/index.php/spcir/article/view/443Revista Portuguesa de Cirurgia; No 40 (2017): Number 40 - March 2017; 35-50Revista Portuguesa de Cirurgia; No 40 (2017): Number 40 - March 2017; 35-502183-11651646-6918reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://revista.spcir.com/index.php/spcir/article/view/443https://revista.spcir.com/index.php/spcir/article/view/443/458Copyright (c) 2017 Revista Portuguesa de Cirurgiainfo:eu-repo/semantics/openAccessMosca, Ana Margarida Saraiva SantosBarbosa, Laura Elisabete2024-03-14T22:05:07Zoai:revista.spcir.com:article/443Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T04:00:49.483122Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Therapeutic Approach of Peritoneal Carcinomatosis in patients with Colorectal Carcinoma
Abordagem Terapêutica da Carcinomatose Peritoneal em doentes com Carcinoma Colorretal
title Therapeutic Approach of Peritoneal Carcinomatosis in patients with Colorectal Carcinoma
spellingShingle Therapeutic Approach of Peritoneal Carcinomatosis in patients with Colorectal Carcinoma
Mosca, Ana Margarida Saraiva Santos
title_short Therapeutic Approach of Peritoneal Carcinomatosis in patients with Colorectal Carcinoma
title_full Therapeutic Approach of Peritoneal Carcinomatosis in patients with Colorectal Carcinoma
title_fullStr Therapeutic Approach of Peritoneal Carcinomatosis in patients with Colorectal Carcinoma
title_full_unstemmed Therapeutic Approach of Peritoneal Carcinomatosis in patients with Colorectal Carcinoma
title_sort Therapeutic Approach of Peritoneal Carcinomatosis in patients with Colorectal Carcinoma
author Mosca, Ana Margarida Saraiva Santos
author_facet Mosca, Ana Margarida Saraiva Santos
Barbosa, Laura Elisabete
author_role author
author2 Barbosa, Laura Elisabete
author2_role author
dc.contributor.author.fl_str_mv Mosca, Ana Margarida Saraiva Santos
Barbosa, Laura Elisabete
description Peritoneal carcinomatosis is an advanced stage of colorectal cancer, with poor prognosis, that has been regarded as an untreatable condition, suitable only for palliative treatment. Over the last decades new treatment options have emerged; cytoreductive surgery in combination with intraperitoneal chemotherapy has increasingly gain acceptance as a treatment for patients with colorectal peritoneal carcinomatosis. Recent clinical studies have suggested that this new approach could result in long-term survival in selected patients. The emerging trend is to regard peritoneal carcinomatosis as a regional metastatic disease, suitable to locoregional treatment. However a successful outcome depends on an appropriate selection of patients: patients with limited peritoneal disease, where complete cytoreduction is achieved have a greater benefit with this new therapeutic strategy. This review sumarizes indications, technical aspects, limitations, outcomes and challenges of this new approach in the treatment of colorectal peritoneal carcinomatosis.
publishDate 2017
dc.date.none.fl_str_mv 2017-03-30
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revista.spcir.com/index.php/spcir/article/view/443
url https://revista.spcir.com/index.php/spcir/article/view/443
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revista.spcir.com/index.php/spcir/article/view/443
https://revista.spcir.com/index.php/spcir/article/view/443/458
dc.rights.driver.fl_str_mv Copyright (c) 2017 Revista Portuguesa de Cirurgia
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Revista Portuguesa de Cirurgia
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Cirurgia
publisher.none.fl_str_mv Sociedade Portuguesa de Cirurgia
dc.source.none.fl_str_mv Revista Portuguesa de Cirurgia; No 40 (2017): Number 40 - March 2017; 35-50
Revista Portuguesa de Cirurgia; No 40 (2017): Number 40 - March 2017; 35-50
2183-1165
1646-6918
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799138182802964480

Registros relacionados