Phlorotannin Extracts from Fucales Characterized by HPLC-DAD-ESI-MSn: Approaches to Hyaluronidase Inhibitory Capacity and Antioxidant Properties

Detalhes bibliográficos
Autor(a) principal: Ferreres, Federico
Data de Publicação: 2012
Outros Autores: Lopes, Graciliana, Gil-Izquierdo, Angel, Andrade, Paula, Sousa, Carla, Mouga, Teresa, Valentão, Patrícia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.8/4068
Resumo: The authors are grateful to Fundação para a Ciência e a Tecnologia (FCT) through grant no. PEst-C/EQB/LA0006/2011, to ―Consolider Ingenio 2010 Project CSD2007-00063 FUN-C-FOOD‖ and to ―Grupo de excelencia de la región de Murcia 04486/GERM/06‖. G. Lopes (SFRH/BD/ 61565/2009) is indebted to FCT, FSE and POPH for the grant.
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spelling Phlorotannin Extracts from Fucales Characterized by HPLC-DAD-ESI-MSn: Approaches to Hyaluronidase Inhibitory Capacity and Antioxidant PropertiesPhlorotanninsSkin agingHyaluronidaseAntioxidant activityHPLC-DAD-ESI-MSnThe authors are grateful to Fundação para a Ciência e a Tecnologia (FCT) through grant no. PEst-C/EQB/LA0006/2011, to ―Consolider Ingenio 2010 Project CSD2007-00063 FUN-C-FOOD‖ and to ―Grupo de excelencia de la región de Murcia 04486/GERM/06‖. G. Lopes (SFRH/BD/ 61565/2009) is indebted to FCT, FSE and POPH for the grant.Purified phlorotannin extracts from four brown seaweeds (Cystoseira nodicaulis (Withering) M. Roberts, Cystoseira tamariscifolia (Hudson) Papenfuss, Cystoseira usneoides (Linnaeus) M. Roberts and Fucus spiralis Linnaeus), were characterized by HPLC-DAD-ESI-MSn . Fucophloroethol, fucodiphloroethol, fucotriphloroethol, 7-phloroeckol, phlorofucofuroeckol and bieckol/dieckol were identified. The antioxidant activity and the hyaluronidase (HAase) inhibitory capacity exhibited by the extracts were also assessed. A correlation between the extracts activity and their chemical composition was established. F. spiralis, the species presenting higher molecular weight phlorotannins, generally displayed the strongest lipid peroxidation inhibitory activity (IC50 = 2.32 mg/mL dry weight) and the strongest HAase inhibitory capacity (IC50 = 0.73 mg/mL dry weight). As for superoxide radical scavenging, C. nodicaulis was the most efficient species (IC50 = 0.93 mg/mL dry weight), followed by F. spiralis (IC50 = 1.30 mg/mL dry weight). These results show that purified phlorotannin extracts have potent capabilities for preventing and slowing down the skin aging process, which is mainly associated with free radical damage and with the reduction of hyaluronic acid concentration, characteristic of the process.IC-OnlineFerreres, FedericoLopes, GracilianaGil-Izquierdo, AngelAndrade, PaulaSousa, CarlaMouga, TeresaValentão, Patrícia2019-09-06T10:36:57Z20122019-09-04T14:56:11Z2012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/4068engFerreres, F.; Lopes, G.; Gil-Izquierdo, A.; Andrade, P.B.; Sousa, C.; Mouga, T.; Valentão, P. Phlorotannin Extracts from Fucales Characterized by HPLC-DAD-ESI-MSn: Approaches to Hyaluronidase Inhibitory Capacity and Antioxidant Properties. Mar. Drugs 2012, 10, 2766-2781.WOS:000312607700012cv-prod-14996110.3390/md10122766info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:48:31Zoai:iconline.ipleiria.pt:10400.8/4068Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:48:01.778255Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Phlorotannin Extracts from Fucales Characterized by HPLC-DAD-ESI-MSn: Approaches to Hyaluronidase Inhibitory Capacity and Antioxidant Properties
title Phlorotannin Extracts from Fucales Characterized by HPLC-DAD-ESI-MSn: Approaches to Hyaluronidase Inhibitory Capacity and Antioxidant Properties
spellingShingle Phlorotannin Extracts from Fucales Characterized by HPLC-DAD-ESI-MSn: Approaches to Hyaluronidase Inhibitory Capacity and Antioxidant Properties
Ferreres, Federico
Phlorotannins
Skin aging
Hyaluronidase
Antioxidant activity
HPLC-DAD-ESI-MSn
title_short Phlorotannin Extracts from Fucales Characterized by HPLC-DAD-ESI-MSn: Approaches to Hyaluronidase Inhibitory Capacity and Antioxidant Properties
title_full Phlorotannin Extracts from Fucales Characterized by HPLC-DAD-ESI-MSn: Approaches to Hyaluronidase Inhibitory Capacity and Antioxidant Properties
title_fullStr Phlorotannin Extracts from Fucales Characterized by HPLC-DAD-ESI-MSn: Approaches to Hyaluronidase Inhibitory Capacity and Antioxidant Properties
title_full_unstemmed Phlorotannin Extracts from Fucales Characterized by HPLC-DAD-ESI-MSn: Approaches to Hyaluronidase Inhibitory Capacity and Antioxidant Properties
title_sort Phlorotannin Extracts from Fucales Characterized by HPLC-DAD-ESI-MSn: Approaches to Hyaluronidase Inhibitory Capacity and Antioxidant Properties
author Ferreres, Federico
author_facet Ferreres, Federico
Lopes, Graciliana
Gil-Izquierdo, Angel
Andrade, Paula
Sousa, Carla
Mouga, Teresa
Valentão, Patrícia
author_role author
author2 Lopes, Graciliana
Gil-Izquierdo, Angel
Andrade, Paula
Sousa, Carla
Mouga, Teresa
Valentão, Patrícia
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv IC-Online
dc.contributor.author.fl_str_mv Ferreres, Federico
Lopes, Graciliana
Gil-Izquierdo, Angel
Andrade, Paula
Sousa, Carla
Mouga, Teresa
Valentão, Patrícia
dc.subject.por.fl_str_mv Phlorotannins
Skin aging
Hyaluronidase
Antioxidant activity
HPLC-DAD-ESI-MSn
topic Phlorotannins
Skin aging
Hyaluronidase
Antioxidant activity
HPLC-DAD-ESI-MSn
description The authors are grateful to Fundação para a Ciência e a Tecnologia (FCT) through grant no. PEst-C/EQB/LA0006/2011, to ―Consolider Ingenio 2010 Project CSD2007-00063 FUN-C-FOOD‖ and to ―Grupo de excelencia de la región de Murcia 04486/GERM/06‖. G. Lopes (SFRH/BD/ 61565/2009) is indebted to FCT, FSE and POPH for the grant.
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-01-01T00:00:00Z
2019-09-06T10:36:57Z
2019-09-04T14:56:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.8/4068
url http://hdl.handle.net/10400.8/4068
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ferreres, F.; Lopes, G.; Gil-Izquierdo, A.; Andrade, P.B.; Sousa, C.; Mouga, T.; Valentão, P. Phlorotannin Extracts from Fucales Characterized by HPLC-DAD-ESI-MSn: Approaches to Hyaluronidase Inhibitory Capacity and Antioxidant Properties. Mar. Drugs 2012, 10, 2766-2781.
WOS:000312607700012
cv-prod-149961
10.3390/md10122766
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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