Introduction to Infrared and Raman-Based Biomedical Molecular Imaging and Comparison with Other Modalities
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/106467 https://doi.org/10.3390/molecules25235547 |
Resumo: | Molecular imaging has rapidly developed to answer the need of image contrast in medical diagnostic imaging to go beyond morphological information to include functional differences in imaged tissues at the cellular and molecular levels. Vibrational (infrared (IR) and Raman) imaging has rapidly emerged among the molecular imaging modalities available, due to its label-free combination of high spatial resolution with chemical specificity. This article presents the physical basis of vibrational spectroscopy and imaging, followed by illustration of their preclinical in vitro applications in body fluids and cells, ex vivo tissues and in vivo small animals and ending with a brief discussion of their clinical translation. After comparing the advantages and disadvantages of IR/Raman imaging with the other main modalities, such as magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography/single-photon emission-computed tomography (PET/SPECT), ultrasound (US) and photoacoustic imaging (PAI), the design of multimodal probes combining vibrational imaging with other modalities is discussed, illustrated by some preclinical proof-of-concept examples. |
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Introduction to Infrared and Raman-Based Biomedical Molecular Imaging and Comparison with Other Modalitiesbio-imagingvibrational spectroscopyinfraredRamanmultimodal imagingAlgorithmsAnimalsHumansMagnetic Resonance ImagingModels, TheoreticalMolecular ImagingPositron-Emission TomographyTomography, X-Ray ComputedUltrasonographyInfrared RaysSpectrum Analysis, RamanMolecular imaging has rapidly developed to answer the need of image contrast in medical diagnostic imaging to go beyond morphological information to include functional differences in imaged tissues at the cellular and molecular levels. Vibrational (infrared (IR) and Raman) imaging has rapidly emerged among the molecular imaging modalities available, due to its label-free combination of high spatial resolution with chemical specificity. This article presents the physical basis of vibrational spectroscopy and imaging, followed by illustration of their preclinical in vitro applications in body fluids and cells, ex vivo tissues and in vivo small animals and ending with a brief discussion of their clinical translation. After comparing the advantages and disadvantages of IR/Raman imaging with the other main modalities, such as magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography/single-photon emission-computed tomography (PET/SPECT), ultrasound (US) and photoacoustic imaging (PAI), the design of multimodal probes combining vibrational imaging with other modalities is discussed, illustrated by some preclinical proof-of-concept examples.MDPI2020-11-26info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/106467http://hdl.handle.net/10316/106467https://doi.org/10.3390/molecules25235547eng1420-3049Geraldes, Carlos F. G. C.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-04-04T20:39:12Zoai:estudogeral.uc.pt:10316/106467Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:22:55.099121Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Introduction to Infrared and Raman-Based Biomedical Molecular Imaging and Comparison with Other Modalities |
title |
Introduction to Infrared and Raman-Based Biomedical Molecular Imaging and Comparison with Other Modalities |
spellingShingle |
Introduction to Infrared and Raman-Based Biomedical Molecular Imaging and Comparison with Other Modalities Geraldes, Carlos F. G. C. bio-imaging vibrational spectroscopy infrared Raman multimodal imaging Algorithms Animals Humans Magnetic Resonance Imaging Models, Theoretical Molecular Imaging Positron-Emission Tomography Tomography, X-Ray Computed Ultrasonography Infrared Rays Spectrum Analysis, Raman |
title_short |
Introduction to Infrared and Raman-Based Biomedical Molecular Imaging and Comparison with Other Modalities |
title_full |
Introduction to Infrared and Raman-Based Biomedical Molecular Imaging and Comparison with Other Modalities |
title_fullStr |
Introduction to Infrared and Raman-Based Biomedical Molecular Imaging and Comparison with Other Modalities |
title_full_unstemmed |
Introduction to Infrared and Raman-Based Biomedical Molecular Imaging and Comparison with Other Modalities |
title_sort |
Introduction to Infrared and Raman-Based Biomedical Molecular Imaging and Comparison with Other Modalities |
author |
Geraldes, Carlos F. G. C. |
author_facet |
Geraldes, Carlos F. G. C. |
author_role |
author |
dc.contributor.author.fl_str_mv |
Geraldes, Carlos F. G. C. |
dc.subject.por.fl_str_mv |
bio-imaging vibrational spectroscopy infrared Raman multimodal imaging Algorithms Animals Humans Magnetic Resonance Imaging Models, Theoretical Molecular Imaging Positron-Emission Tomography Tomography, X-Ray Computed Ultrasonography Infrared Rays Spectrum Analysis, Raman |
topic |
bio-imaging vibrational spectroscopy infrared Raman multimodal imaging Algorithms Animals Humans Magnetic Resonance Imaging Models, Theoretical Molecular Imaging Positron-Emission Tomography Tomography, X-Ray Computed Ultrasonography Infrared Rays Spectrum Analysis, Raman |
description |
Molecular imaging has rapidly developed to answer the need of image contrast in medical diagnostic imaging to go beyond morphological information to include functional differences in imaged tissues at the cellular and molecular levels. Vibrational (infrared (IR) and Raman) imaging has rapidly emerged among the molecular imaging modalities available, due to its label-free combination of high spatial resolution with chemical specificity. This article presents the physical basis of vibrational spectroscopy and imaging, followed by illustration of their preclinical in vitro applications in body fluids and cells, ex vivo tissues and in vivo small animals and ending with a brief discussion of their clinical translation. After comparing the advantages and disadvantages of IR/Raman imaging with the other main modalities, such as magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography/single-photon emission-computed tomography (PET/SPECT), ultrasound (US) and photoacoustic imaging (PAI), the design of multimodal probes combining vibrational imaging with other modalities is discussed, illustrated by some preclinical proof-of-concept examples. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-11-26 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/106467 http://hdl.handle.net/10316/106467 https://doi.org/10.3390/molecules25235547 |
url |
http://hdl.handle.net/10316/106467 https://doi.org/10.3390/molecules25235547 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1420-3049 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134117284020224 |