Boosting the clinical translation of organ-on-a-chip technology
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/80169 |
Resumo: | Organ-on-a-chip devices have become a viable option for investigating critical physiological events and responses; this technology has matured substantially, and many systems have been reported for disease modeling or drug screening over the last decade. Despite the wide acceptance in the academic community, their adoption by clinical end-users is still a non-accomplished promise. The reasons behind this difficulty can be very diverse but most likely are related to the lack of predictive power, physiological relevance, and reliability necessary for being utilized in the clinical area. In this Perspective, we briefly discuss the main attributes of organ-on-a-chip platforms in academia and how these characteristics impede their easy translation to the clinic. We also discuss how academia, in conjunction with the industry, can contribute to boosting their adoption by proposing novel design concepts, fabrication methods, processes, and manufacturing materials, improving their standardization and versatility, and simplifying their manipulation and reusability. |
id |
RCAP_880c7ecce61d1c57b54848bbe0fc675a |
---|---|
oai_identifier_str |
oai:repositorium.sdum.uminho.pt:1822/80169 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Boosting the clinical translation of organ-on-a-chip technologyClinical Translationdisease modellingdrug discoverydrug screeningMicrofluidicsOrgan-on-a-chippersonalized medicineScience & TechnologyOrgan-on-a-chip devices have become a viable option for investigating critical physiological events and responses; this technology has matured substantially, and many systems have been reported for disease modeling or drug screening over the last decade. Despite the wide acceptance in the academic community, their adoption by clinical end-users is still a non-accomplished promise. The reasons behind this difficulty can be very diverse but most likely are related to the lack of predictive power, physiological relevance, and reliability necessary for being utilized in the clinical area. In this Perspective, we briefly discuss the main attributes of organ-on-a-chip platforms in academia and how these characteristics impede their easy translation to the clinic. We also discuss how academia, in conjunction with the industry, can contribute to boosting their adoption by proposing novel design concepts, fabrication methods, processes, and manufacturing materials, improving their standardization and versatility, and simplifying their manipulation and reusability.This research was funded by the Portuguese Foundation for Science and Technology (FCT) under the program CEEC Individual 2017 (CEECIND/00352/2017) and the project 2MATCH (PTDC/BTM-ORG/28070/2017) funded by the Programa Operacional Regional do Norte supported by European Regional Development Funds (ERDF).MDPIUniversidade do MinhoCaballero, DavidReis, R. L.Kundu, Subhas C2022-102022-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/80169engCaballero, D.; Reis, R.L.; Kundu, S.C. Boosting the Clinical Translation of Organ-On-A-Chip Technology. Bioengineering 2022, 9, 549. https://doi.org/10.3390/bioengineering91005492306-535410.3390/bioengineering9100549https://www.mdpi.com/2306-5354/9/10/549info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:36:48Zoai:repositorium.sdum.uminho.pt:1822/80169Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:32:59.255755Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Boosting the clinical translation of organ-on-a-chip technology |
title |
Boosting the clinical translation of organ-on-a-chip technology |
spellingShingle |
Boosting the clinical translation of organ-on-a-chip technology Caballero, David Clinical Translation disease modelling drug discovery drug screening Microfluidics Organ-on-a-chip personalized medicine Science & Technology |
title_short |
Boosting the clinical translation of organ-on-a-chip technology |
title_full |
Boosting the clinical translation of organ-on-a-chip technology |
title_fullStr |
Boosting the clinical translation of organ-on-a-chip technology |
title_full_unstemmed |
Boosting the clinical translation of organ-on-a-chip technology |
title_sort |
Boosting the clinical translation of organ-on-a-chip technology |
author |
Caballero, David |
author_facet |
Caballero, David Reis, R. L. Kundu, Subhas C |
author_role |
author |
author2 |
Reis, R. L. Kundu, Subhas C |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Caballero, David Reis, R. L. Kundu, Subhas C |
dc.subject.por.fl_str_mv |
Clinical Translation disease modelling drug discovery drug screening Microfluidics Organ-on-a-chip personalized medicine Science & Technology |
topic |
Clinical Translation disease modelling drug discovery drug screening Microfluidics Organ-on-a-chip personalized medicine Science & Technology |
description |
Organ-on-a-chip devices have become a viable option for investigating critical physiological events and responses; this technology has matured substantially, and many systems have been reported for disease modeling or drug screening over the last decade. Despite the wide acceptance in the academic community, their adoption by clinical end-users is still a non-accomplished promise. The reasons behind this difficulty can be very diverse but most likely are related to the lack of predictive power, physiological relevance, and reliability necessary for being utilized in the clinical area. In this Perspective, we briefly discuss the main attributes of organ-on-a-chip platforms in academia and how these characteristics impede their easy translation to the clinic. We also discuss how academia, in conjunction with the industry, can contribute to boosting their adoption by proposing novel design concepts, fabrication methods, processes, and manufacturing materials, improving their standardization and versatility, and simplifying their manipulation and reusability. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-10 2022-10-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/80169 |
url |
https://hdl.handle.net/1822/80169 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Caballero, D.; Reis, R.L.; Kundu, S.C. Boosting the Clinical Translation of Organ-On-A-Chip Technology. Bioengineering 2022, 9, 549. https://doi.org/10.3390/bioengineering9100549 2306-5354 10.3390/bioengineering9100549 https://www.mdpi.com/2306-5354/9/10/549 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799132845376012288 |