Cross-sectional study of risk factors for atherosclerosis in the Azorean population

Detalhes bibliográficos
Autor(a) principal: Cymbron, Teresa
Data de Publicação: 2011
Outros Autores: Raposo, Mafalda, Kazachkova, Nadia, Bettencourt, Conceição, Silva, Francisca, Santos, Cristina, Dahmani, Yahya, Lourenço, Paula C., Ferin, Rita, Pavão, Maria Leonor, Lima, Manuela
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.3/2744
Resumo: Copyright © 2011 Informa UK Ltd.
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spelling Cross-sectional study of risk factors for atherosclerosis in the Azorean populationPolymorphismsSusceptibility GenesAtherosclerosisIschemic Heart DiseaseAzoresCopyright © 2011 Informa UK Ltd.Background: Atherosclerosis -a major cause of vascular disease, including ischemic heart disease (IHD), is a pathology that has a two-fold higher mortality rate in the Azorean Islands compared to mainland Portugal. Aim: This cross-sectional study investigated the role of genetic variation in the prevalence of atherosclerosis in this population. Subjects and methods: A total of 305 individuals were characterized for polymorphisms in eight susceptibility genes for atherosclerosis: ACE, PAI1, NOS3, LTA, FGB, ITGB3, PON1 and APOE. Data were analysed with respect to phenotypic characteristics such as blood pressure, lipid profile, life-style risk factors and familial history of myocardial infarction. Results: In the total sample, frequencies for hypercholestrolemic, hypertensive and obese individuals were 63.6%, 39.3% and 23.3%, respectively. The genetic profile was similar to that observed in other European populations, namely in mainland Portugal. No over-representation of risk alleles was evidenced in this sample. Conclusions: One has to consider the possibility of an important non-genetic influence on the high cholesterolemia present in the Azorean population. Since diet is the most important life-style risk factor for dyslipidemia, studies aiming to evaluate the dietary characteristics of this population and its impact on serum lipid levels will be of major importance.Governo Regional dos Açores; Instituto de Biotecnologia e Biomedicina dos Açores.Informa HealthcareRepositório da Universidade dos AçoresCymbron, TeresaRaposo, MafaldaKazachkova, NadiaBettencourt, ConceiçãoSilva, FranciscaSantos, CristinaDahmani, YahyaLourenço, Paula C.Ferin, RitaPavão, Maria LeonorLima, Manuela2014-02-11T12:55:37Z20112011-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.3/2744engCYMBRON, T., RAPOSO, M., KAZACHKOVA, N., BETTENCOURT, C., SILVA, F., SANTOS, C., DAHMANI, Y., LOURENÇO, P., FERIN, R., PAVÃO, M.L: & LIMA (2011). "Cross-sectional study of risk factors for atherosclerosis in the Azorean population", Annals of Human Biology, 2011, Early Online: 1-6. http://dx.doi.org/10.3109/03014460.2011.553203.0301-4460 (Print)info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-12-20T14:30:36ZPortal AgregadorONG
dc.title.none.fl_str_mv Cross-sectional study of risk factors for atherosclerosis in the Azorean population
title Cross-sectional study of risk factors for atherosclerosis in the Azorean population
spellingShingle Cross-sectional study of risk factors for atherosclerosis in the Azorean population
Cymbron, Teresa
Polymorphisms
Susceptibility Genes
Atherosclerosis
Ischemic Heart Disease
Azores
title_short Cross-sectional study of risk factors for atherosclerosis in the Azorean population
title_full Cross-sectional study of risk factors for atherosclerosis in the Azorean population
title_fullStr Cross-sectional study of risk factors for atherosclerosis in the Azorean population
title_full_unstemmed Cross-sectional study of risk factors for atherosclerosis in the Azorean population
title_sort Cross-sectional study of risk factors for atherosclerosis in the Azorean population
author Cymbron, Teresa
author_facet Cymbron, Teresa
Raposo, Mafalda
Kazachkova, Nadia
Bettencourt, Conceição
Silva, Francisca
Santos, Cristina
Dahmani, Yahya
Lourenço, Paula C.
Ferin, Rita
Pavão, Maria Leonor
Lima, Manuela
author_role author
author2 Raposo, Mafalda
Kazachkova, Nadia
Bettencourt, Conceição
Silva, Francisca
Santos, Cristina
Dahmani, Yahya
Lourenço, Paula C.
Ferin, Rita
Pavão, Maria Leonor
Lima, Manuela
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade dos Açores
dc.contributor.author.fl_str_mv Cymbron, Teresa
Raposo, Mafalda
Kazachkova, Nadia
Bettencourt, Conceição
Silva, Francisca
Santos, Cristina
Dahmani, Yahya
Lourenço, Paula C.
Ferin, Rita
Pavão, Maria Leonor
Lima, Manuela
dc.subject.por.fl_str_mv Polymorphisms
Susceptibility Genes
Atherosclerosis
Ischemic Heart Disease
Azores
topic Polymorphisms
Susceptibility Genes
Atherosclerosis
Ischemic Heart Disease
Azores
description Copyright © 2011 Informa UK Ltd.
publishDate 2011
dc.date.none.fl_str_mv 2011
2011-01-01T00:00:00Z
2014-02-11T12:55:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.3/2744
url http://hdl.handle.net/10400.3/2744
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv CYMBRON, T., RAPOSO, M., KAZACHKOVA, N., BETTENCOURT, C., SILVA, F., SANTOS, C., DAHMANI, Y., LOURENÇO, P., FERIN, R., PAVÃO, M.L: & LIMA (2011). "Cross-sectional study of risk factors for atherosclerosis in the Azorean population", Annals of Human Biology, 2011, Early Online: 1-6. http://dx.doi.org/10.3109/03014460.2011.553203.
0301-4460 (Print)
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Informa Healthcare
publisher.none.fl_str_mv Informa Healthcare
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.mail.fl_str_mv
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