Extraction of high value triterpenic acids from eucalyptus globulus biomass using hydrophobic deep eutectic solvents

Detalhes bibliográficos
Autor(a) principal: Silva, Nuno H. C. S.
Data de Publicação: 2020
Outros Autores: Morais, Eduarda S., Carmen S. R. Freire, Freire, Mara G., Silvestre, Armando J. D.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/28166
Resumo: Triterpenic acids (TTAs), known for their promising biological properties, can be found in different biomass sources and related by-products, such as Eucalyptus globulus bark, and have been extracted using organic volatile solvents such as dichloromethane. Recently, deep eutectic solvents (DES) have been identified as promising alternatives for the extraction of value-added compounds from biomass. In the present work, several hydrophobic DES were tested for the extraction of TTAs from E. globulus bark. Initial solubility studies revealed that DES based on menthol and thymol as the most promising solvents for these compounds given the highest solubilities obtained for ursolic acid (UA) at temperatures ranging from room temperature up to 90 °C. Accordingly, an eutectic mixture of menthol:thymol (1:2) was confirmed as the best candidate for the TTAs extraction from E. globulus outer bark, leading to extraction yields (weight of TTA per weight of biomass) at room temperature of 1.8 wt% for ursolic acid, 0.84 wt% for oleanolic acid and 0.30 wt% for betulinic acid. These values are significantly higher than those obtained with conventional organic solvents under similar conditions. The results obtained using these DES are promising for the recovery of TTAs for nutraceutical and pharmacological applications, while reinforcing the potential of DES as promising solvents to be applied in biorefinery processes.
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spelling Extraction of high value triterpenic acids from eucalyptus globulus biomass using hydrophobic deep eutectic solventsTriterpenic acidsUrsolic acidEucalyptus globulus outer barkHydrophobic deep eutectic solventsMentholThymolTriterpenic acids (TTAs), known for their promising biological properties, can be found in different biomass sources and related by-products, such as Eucalyptus globulus bark, and have been extracted using organic volatile solvents such as dichloromethane. Recently, deep eutectic solvents (DES) have been identified as promising alternatives for the extraction of value-added compounds from biomass. In the present work, several hydrophobic DES were tested for the extraction of TTAs from E. globulus bark. Initial solubility studies revealed that DES based on menthol and thymol as the most promising solvents for these compounds given the highest solubilities obtained for ursolic acid (UA) at temperatures ranging from room temperature up to 90 °C. Accordingly, an eutectic mixture of menthol:thymol (1:2) was confirmed as the best candidate for the TTAs extraction from E. globulus outer bark, leading to extraction yields (weight of TTA per weight of biomass) at room temperature of 1.8 wt% for ursolic acid, 0.84 wt% for oleanolic acid and 0.30 wt% for betulinic acid. These values are significantly higher than those obtained with conventional organic solvents under similar conditions. The results obtained using these DES are promising for the recovery of TTAs for nutraceutical and pharmacological applications, while reinforcing the potential of DES as promising solvents to be applied in biorefinery processes.MDPD2020-04-02T15:40:38Z2020-01-04T00:00:00Z2020-01-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/28166eng1420-304910.3390/molecules25010210Silva, Nuno H. C. S.Morais, Eduarda S.Carmen S. R. FreireFreire, Mara G.Silvestre, Armando J. D.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:54:31Zoai:ria.ua.pt:10773/28166Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:00:46.861952Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Extraction of high value triterpenic acids from eucalyptus globulus biomass using hydrophobic deep eutectic solvents
title Extraction of high value triterpenic acids from eucalyptus globulus biomass using hydrophobic deep eutectic solvents
spellingShingle Extraction of high value triterpenic acids from eucalyptus globulus biomass using hydrophobic deep eutectic solvents
Silva, Nuno H. C. S.
Triterpenic acids
Ursolic acid
Eucalyptus globulus outer bark
Hydrophobic deep eutectic solvents
Menthol
Thymol
title_short Extraction of high value triterpenic acids from eucalyptus globulus biomass using hydrophobic deep eutectic solvents
title_full Extraction of high value triterpenic acids from eucalyptus globulus biomass using hydrophobic deep eutectic solvents
title_fullStr Extraction of high value triterpenic acids from eucalyptus globulus biomass using hydrophobic deep eutectic solvents
title_full_unstemmed Extraction of high value triterpenic acids from eucalyptus globulus biomass using hydrophobic deep eutectic solvents
title_sort Extraction of high value triterpenic acids from eucalyptus globulus biomass using hydrophobic deep eutectic solvents
author Silva, Nuno H. C. S.
author_facet Silva, Nuno H. C. S.
Morais, Eduarda S.
Carmen S. R. Freire
Freire, Mara G.
Silvestre, Armando J. D.
author_role author
author2 Morais, Eduarda S.
Carmen S. R. Freire
Freire, Mara G.
Silvestre, Armando J. D.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Silva, Nuno H. C. S.
Morais, Eduarda S.
Carmen S. R. Freire
Freire, Mara G.
Silvestre, Armando J. D.
dc.subject.por.fl_str_mv Triterpenic acids
Ursolic acid
Eucalyptus globulus outer bark
Hydrophobic deep eutectic solvents
Menthol
Thymol
topic Triterpenic acids
Ursolic acid
Eucalyptus globulus outer bark
Hydrophobic deep eutectic solvents
Menthol
Thymol
description Triterpenic acids (TTAs), known for their promising biological properties, can be found in different biomass sources and related by-products, such as Eucalyptus globulus bark, and have been extracted using organic volatile solvents such as dichloromethane. Recently, deep eutectic solvents (DES) have been identified as promising alternatives for the extraction of value-added compounds from biomass. In the present work, several hydrophobic DES were tested for the extraction of TTAs from E. globulus bark. Initial solubility studies revealed that DES based on menthol and thymol as the most promising solvents for these compounds given the highest solubilities obtained for ursolic acid (UA) at temperatures ranging from room temperature up to 90 °C. Accordingly, an eutectic mixture of menthol:thymol (1:2) was confirmed as the best candidate for the TTAs extraction from E. globulus outer bark, leading to extraction yields (weight of TTA per weight of biomass) at room temperature of 1.8 wt% for ursolic acid, 0.84 wt% for oleanolic acid and 0.30 wt% for betulinic acid. These values are significantly higher than those obtained with conventional organic solvents under similar conditions. The results obtained using these DES are promising for the recovery of TTAs for nutraceutical and pharmacological applications, while reinforcing the potential of DES as promising solvents to be applied in biorefinery processes.
publishDate 2020
dc.date.none.fl_str_mv 2020-04-02T15:40:38Z
2020-01-04T00:00:00Z
2020-01-04
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/28166
url http://hdl.handle.net/10773/28166
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1420-3049
10.3390/molecules25010210
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