Molecularly Imprinted Solid Phase Extraction Aiding the Analysis of Disease Biomarkers

Detalhes bibliográficos
Autor(a) principal: Silva, Matheus Siqueira
Data de Publicação: 2020
Outros Autores: Tavares, Ana Patricia Moreira, Faria, Henrique Dipe de, Sales, Maria Goreti Ferreira, Figueiredo, Eduardo Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/18571
Resumo: Low concentrations of biomarkers as well as the complexity of biological samples make the clinical diagnoses of several diseases a challenging task. Sample preparation protocols remain a fundamental piece in the puzzle of analytical processes, and smart sorbents including molecularly imprinted polymers (MIPs) have been successfully used in this case. In this review, we depict the state of art for the rational design of MIPs to be used in solid phase extraction of disease biomarkers from biological samples. The topics are divided into (1) strategies for MIP syntheses, (2) setups for sample preparation protocols with MIPs, (3) the applications of these combined principles in the analyses of different classes of disease biomarkers, and (4) remaining challenges and future trends for the application of Molecular Imprinting Technology in sample preparation for clinical diagnosis.
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spelling Molecularly Imprinted Solid Phase Extraction Aiding the Analysis of Disease BiomarkersBiological samplesDisease biomarkersMolecularly imprinted polymersSample preparationSolid phase extractionLow concentrations of biomarkers as well as the complexity of biological samples make the clinical diagnoses of several diseases a challenging task. Sample preparation protocols remain a fundamental piece in the puzzle of analytical processes, and smart sorbents including molecularly imprinted polymers (MIPs) have been successfully used in this case. In this review, we depict the state of art for the rational design of MIPs to be used in solid phase extraction of disease biomarkers from biological samples. The topics are divided into (1) strategies for MIP syntheses, (2) setups for sample preparation protocols with MIPs, (3) the applications of these combined principles in the analyses of different classes of disease biomarkers, and (4) remaining challenges and future trends for the application of Molecular Imprinting Technology in sample preparation for clinical diagnosis.The authors are thankful to the Fundação à Pesquisa do Estado de Minas Gerais (FAPEMIG, Belo Horizonte, Brazil); the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brasilia, Brazil) and the Coordination for the Improvement of Higher Education Personnel (CAPES, Brasilia, Brazil) for financial support (process 88881.133746/2016-01) and the scholarship funding for Matheus Siqueira Silva/PDSE/ Processo no. {88881.133746/2016-01}.Taylor and FrancisRepositório Científico do Instituto Politécnico do PortoSilva, Matheus SiqueiraTavares, Ana Patricia MoreiraFaria, Henrique Dipe deSales, Maria Goreti FerreiraFigueiredo, Eduardo Costa2021-11-01T01:30:26Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/18571eng1040-834710.1080/10408347.2020.1843131info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T13:09:55Zoai:recipp.ipp.pt:10400.22/18571Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:37:55.095025Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Molecularly Imprinted Solid Phase Extraction Aiding the Analysis of Disease Biomarkers
title Molecularly Imprinted Solid Phase Extraction Aiding the Analysis of Disease Biomarkers
spellingShingle Molecularly Imprinted Solid Phase Extraction Aiding the Analysis of Disease Biomarkers
Silva, Matheus Siqueira
Biological samples
Disease biomarkers
Molecularly imprinted polymers
Sample preparation
Solid phase extraction
title_short Molecularly Imprinted Solid Phase Extraction Aiding the Analysis of Disease Biomarkers
title_full Molecularly Imprinted Solid Phase Extraction Aiding the Analysis of Disease Biomarkers
title_fullStr Molecularly Imprinted Solid Phase Extraction Aiding the Analysis of Disease Biomarkers
title_full_unstemmed Molecularly Imprinted Solid Phase Extraction Aiding the Analysis of Disease Biomarkers
title_sort Molecularly Imprinted Solid Phase Extraction Aiding the Analysis of Disease Biomarkers
author Silva, Matheus Siqueira
author_facet Silva, Matheus Siqueira
Tavares, Ana Patricia Moreira
Faria, Henrique Dipe de
Sales, Maria Goreti Ferreira
Figueiredo, Eduardo Costa
author_role author
author2 Tavares, Ana Patricia Moreira
Faria, Henrique Dipe de
Sales, Maria Goreti Ferreira
Figueiredo, Eduardo Costa
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Silva, Matheus Siqueira
Tavares, Ana Patricia Moreira
Faria, Henrique Dipe de
Sales, Maria Goreti Ferreira
Figueiredo, Eduardo Costa
dc.subject.por.fl_str_mv Biological samples
Disease biomarkers
Molecularly imprinted polymers
Sample preparation
Solid phase extraction
topic Biological samples
Disease biomarkers
Molecularly imprinted polymers
Sample preparation
Solid phase extraction
description Low concentrations of biomarkers as well as the complexity of biological samples make the clinical diagnoses of several diseases a challenging task. Sample preparation protocols remain a fundamental piece in the puzzle of analytical processes, and smart sorbents including molecularly imprinted polymers (MIPs) have been successfully used in this case. In this review, we depict the state of art for the rational design of MIPs to be used in solid phase extraction of disease biomarkers from biological samples. The topics are divided into (1) strategies for MIP syntheses, (2) setups for sample preparation protocols with MIPs, (3) the applications of these combined principles in the analyses of different classes of disease biomarkers, and (4) remaining challenges and future trends for the application of Molecular Imprinting Technology in sample preparation for clinical diagnosis.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
2021-11-01T01:30:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/18571
url http://hdl.handle.net/10400.22/18571
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1040-8347
10.1080/10408347.2020.1843131
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor and Francis
publisher.none.fl_str_mv Taylor and Francis
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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