Skin tests and challenge-based drug allergy diagnosis: a retrospective study of patients with confirmed drug allergy
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.26/31694 |
Resumo: | Objectives. To describe clinical manifestations and performed diagnostic workup, focusing drug challenge tests (DCT), in patients with drug allergy. Methods. Retrospective study including all patients with skin tests (STs) or DCT-based drug allergy diagnosis, between 01/2014 - 06/2018 in a Portuguese allergy unit. Data were collected from electronic and paper-based clinical records. Results. We had 75 drug allergy diagnoses. Most index reactions were mild and major or equal 1 hour after drug intake. 59 (78%) diagnoses were based on DCTs, all based on multistep protocols with major or equal 3 predicted steps. Only 10% of the DCT were positive during up-dosing; timing and severity of the index reaction predicted DCT interruption during up-dosing. Conclusions. Most drug allergy diagnoses were based on multistep DCT. The identified predictors of DCT interruption during up-dosing can support the development of more personalized DCTs protocols. |
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Skin tests and challenge-based drug allergy diagnosis: a retrospective study of patients with confirmed drug allergyDrug HypersensitivityHypersensitivity, ImmediateHipersensibilidade a MedicamentosHipersensibilidade ImediataObjectives. To describe clinical manifestations and performed diagnostic workup, focusing drug challenge tests (DCT), in patients with drug allergy. Methods. Retrospective study including all patients with skin tests (STs) or DCT-based drug allergy diagnosis, between 01/2014 - 06/2018 in a Portuguese allergy unit. Data were collected from electronic and paper-based clinical records. Results. We had 75 drug allergy diagnoses. Most index reactions were mild and major or equal 1 hour after drug intake. 59 (78%) diagnoses were based on DCTs, all based on multistep protocols with major or equal 3 predicted steps. Only 10% of the DCT were positive during up-dosing; timing and severity of the index reaction predicted DCT interruption during up-dosing. Conclusions. Most drug allergy diagnoses were based on multistep DCT. The identified predictors of DCT interruption during up-dosing can support the development of more personalized DCTs protocols.Repositório ComumPereira, AMCouto, MPereira, MAraújo, L2020-03-11T22:47:24Z2020-032020-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/31694engEur Ann Allergy Clin Immunol. 2020 Mar;52(2):74-83.10.23822/EurAnnACI.1764-1489.107info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-12-20T14:25:20Zoai:comum.rcaap.pt:10400.26/31694Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:22:54.545704Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Skin tests and challenge-based drug allergy diagnosis: a retrospective study of patients with confirmed drug allergy |
title |
Skin tests and challenge-based drug allergy diagnosis: a retrospective study of patients with confirmed drug allergy |
spellingShingle |
Skin tests and challenge-based drug allergy diagnosis: a retrospective study of patients with confirmed drug allergy Pereira, AM Drug Hypersensitivity Hypersensitivity, Immediate Hipersensibilidade a Medicamentos Hipersensibilidade Imediata |
title_short |
Skin tests and challenge-based drug allergy diagnosis: a retrospective study of patients with confirmed drug allergy |
title_full |
Skin tests and challenge-based drug allergy diagnosis: a retrospective study of patients with confirmed drug allergy |
title_fullStr |
Skin tests and challenge-based drug allergy diagnosis: a retrospective study of patients with confirmed drug allergy |
title_full_unstemmed |
Skin tests and challenge-based drug allergy diagnosis: a retrospective study of patients with confirmed drug allergy |
title_sort |
Skin tests and challenge-based drug allergy diagnosis: a retrospective study of patients with confirmed drug allergy |
author |
Pereira, AM |
author_facet |
Pereira, AM Couto, M Pereira, M Araújo, L |
author_role |
author |
author2 |
Couto, M Pereira, M Araújo, L |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Repositório Comum |
dc.contributor.author.fl_str_mv |
Pereira, AM Couto, M Pereira, M Araújo, L |
dc.subject.por.fl_str_mv |
Drug Hypersensitivity Hypersensitivity, Immediate Hipersensibilidade a Medicamentos Hipersensibilidade Imediata |
topic |
Drug Hypersensitivity Hypersensitivity, Immediate Hipersensibilidade a Medicamentos Hipersensibilidade Imediata |
description |
Objectives. To describe clinical manifestations and performed diagnostic workup, focusing drug challenge tests (DCT), in patients with drug allergy. Methods. Retrospective study including all patients with skin tests (STs) or DCT-based drug allergy diagnosis, between 01/2014 - 06/2018 in a Portuguese allergy unit. Data were collected from electronic and paper-based clinical records. Results. We had 75 drug allergy diagnoses. Most index reactions were mild and major or equal 1 hour after drug intake. 59 (78%) diagnoses were based on DCTs, all based on multistep protocols with major or equal 3 predicted steps. Only 10% of the DCT were positive during up-dosing; timing and severity of the index reaction predicted DCT interruption during up-dosing. Conclusions. Most drug allergy diagnoses were based on multistep DCT. The identified predictors of DCT interruption during up-dosing can support the development of more personalized DCTs protocols. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-03-11T22:47:24Z 2020-03 2020-03-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.26/31694 |
url |
http://hdl.handle.net/10400.26/31694 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Eur Ann Allergy Clin Immunol. 2020 Mar;52(2):74-83. 10.23822/EurAnnACI.1764-1489.107 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799130674447253504 |