Risk Calculators in Bipolar Disorder: A Systematic Review

Detalhes bibliográficos
Autor(a) principal: Ribeiro, Joana Silva
Data de Publicação: 2020
Outros Autores: Pereira, Daniela, Salagre, Estela, Coroa, Manuel, Santos Oliveira, Pedro, Santos, Vítor, Madeira, Nuno, Grande, Iria, Vieta, Eduard
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/105841
https://doi.org/10.3390/brainsci10080525
Resumo: Introduction: Early recognition of bipolar disorder improves the prognosis and decreases the burden of the disease. However, there is a significant delay in diagnosis. Multiple risk factors for bipolar disorder have been identified and a population at high-risk for the disorder has been more precisely defined. These advances have allowed the development of risk calculators to predict individual risk of conversion to bipolar disorder. This review aims to identify the risk calculators for bipolar disorder and assess their clinical applicability. Methods: A systematic review of original studies on the development of risk calculators in bipolar disorder was performed. The studies’ quality was evaluated with the Newcastle-Ottawa Quality Assessment Form for Cohort Studies and according to recommendations of the Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis Initiative. Results: Three studies met the inclusion criteria; one developed a risk calculator of conversion from major depressive episode to bipolar disorder; one of conversion to new-onset bipolar spectrum disorders in o spring of parents with bipolar disorder; and the last one of conversion in youths with bipolar disorder not-otherwise-specified. Conclusions: The calculators reviewed in this article present good discrimination power for bipolar disorder, although future replication and validation of the models is needed.
id RCAP_89656c005720cf0c7005478f93178250
oai_identifier_str oai:estudogeral.uc.pt:10316/105841
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Risk Calculators in Bipolar Disorder: A Systematic Reviewbipolar disorderbipolar depressionrisk predictionrisk calculatorrisk scoreIntroduction: Early recognition of bipolar disorder improves the prognosis and decreases the burden of the disease. However, there is a significant delay in diagnosis. Multiple risk factors for bipolar disorder have been identified and a population at high-risk for the disorder has been more precisely defined. These advances have allowed the development of risk calculators to predict individual risk of conversion to bipolar disorder. This review aims to identify the risk calculators for bipolar disorder and assess their clinical applicability. Methods: A systematic review of original studies on the development of risk calculators in bipolar disorder was performed. The studies’ quality was evaluated with the Newcastle-Ottawa Quality Assessment Form for Cohort Studies and according to recommendations of the Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis Initiative. Results: Three studies met the inclusion criteria; one developed a risk calculator of conversion from major depressive episode to bipolar disorder; one of conversion to new-onset bipolar spectrum disorders in o spring of parents with bipolar disorder; and the last one of conversion in youths with bipolar disorder not-otherwise-specified. Conclusions: The calculators reviewed in this article present good discrimination power for bipolar disorder, although future replication and validation of the models is needed.MDPI2020-08-06info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/105841http://hdl.handle.net/10316/105841https://doi.org/10.3390/brainsci10080525eng2076-3425Ribeiro, Joana SilvaPereira, DanielaSalagre, EstelaCoroa, ManuelSantos Oliveira, PedroSantos, VítorMadeira, NunoGrande, IriaVieta, Eduardinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T21:34:17Zoai:estudogeral.uc.pt:10316/105841Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:22:20.410763Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Risk Calculators in Bipolar Disorder: A Systematic Review
title Risk Calculators in Bipolar Disorder: A Systematic Review
spellingShingle Risk Calculators in Bipolar Disorder: A Systematic Review
Ribeiro, Joana Silva
bipolar disorder
bipolar depression
risk prediction
risk calculator
risk score
title_short Risk Calculators in Bipolar Disorder: A Systematic Review
title_full Risk Calculators in Bipolar Disorder: A Systematic Review
title_fullStr Risk Calculators in Bipolar Disorder: A Systematic Review
title_full_unstemmed Risk Calculators in Bipolar Disorder: A Systematic Review
title_sort Risk Calculators in Bipolar Disorder: A Systematic Review
author Ribeiro, Joana Silva
author_facet Ribeiro, Joana Silva
Pereira, Daniela
Salagre, Estela
Coroa, Manuel
Santos Oliveira, Pedro
Santos, Vítor
Madeira, Nuno
Grande, Iria
Vieta, Eduard
author_role author
author2 Pereira, Daniela
Salagre, Estela
Coroa, Manuel
Santos Oliveira, Pedro
Santos, Vítor
Madeira, Nuno
Grande, Iria
Vieta, Eduard
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ribeiro, Joana Silva
Pereira, Daniela
Salagre, Estela
Coroa, Manuel
Santos Oliveira, Pedro
Santos, Vítor
Madeira, Nuno
Grande, Iria
Vieta, Eduard
dc.subject.por.fl_str_mv bipolar disorder
bipolar depression
risk prediction
risk calculator
risk score
topic bipolar disorder
bipolar depression
risk prediction
risk calculator
risk score
description Introduction: Early recognition of bipolar disorder improves the prognosis and decreases the burden of the disease. However, there is a significant delay in diagnosis. Multiple risk factors for bipolar disorder have been identified and a population at high-risk for the disorder has been more precisely defined. These advances have allowed the development of risk calculators to predict individual risk of conversion to bipolar disorder. This review aims to identify the risk calculators for bipolar disorder and assess their clinical applicability. Methods: A systematic review of original studies on the development of risk calculators in bipolar disorder was performed. The studies’ quality was evaluated with the Newcastle-Ottawa Quality Assessment Form for Cohort Studies and according to recommendations of the Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis Initiative. Results: Three studies met the inclusion criteria; one developed a risk calculator of conversion from major depressive episode to bipolar disorder; one of conversion to new-onset bipolar spectrum disorders in o spring of parents with bipolar disorder; and the last one of conversion in youths with bipolar disorder not-otherwise-specified. Conclusions: The calculators reviewed in this article present good discrimination power for bipolar disorder, although future replication and validation of the models is needed.
publishDate 2020
dc.date.none.fl_str_mv 2020-08-06
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/105841
http://hdl.handle.net/10316/105841
https://doi.org/10.3390/brainsci10080525
url http://hdl.handle.net/10316/105841
https://doi.org/10.3390/brainsci10080525
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2076-3425
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799134112867418112