Antifungal susceptibility of 175 Aspergillus isolates from various clinical and environmental sources
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/4302 |
Resumo: | Some environmental Aspergillus spp. isolates have been described as resistant to antifungals, potentially causing an emerging medical problem. In the present work, the antifungal susceptibility profile of 41 clinical and 134 environmental isolates of Aspergillus was determined using the CLSI microdilution method. The aim of this study was to compare environmental and clinical isolates with respect to their susceptibility, and assess the potential implications for therapy of isolates encountered in different environments. To our knowledge, this is the first report comparing antifungal susceptibility profiles of Aspergillus collected from different environmental sources (poultries, swineries, beach sand, and hospital environment). Significant differences were found in the distribution of the different species sections for the different sources. Significant differences were also found in the susceptibility profile of the different Aspergillus sections recovered from the various sources. Clear differences were found between the susceptibility of clinical and environmental isolates for caspofungin, amphotericin B and posaconazole, with clinical isolates showing overall greater susceptibility, except for caspofungin. In comparison to clinical isolates, hospital environmental isolates showed significantly less susceptibility to amphotericin B and posaconazole. These data indicate that species section identity and the site from which the isolate was recovered influence the antifungal susceptibility profile, which may affect initial antifungal choices. |
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Antifungal susceptibility of 175 Aspergillus isolates from various clinical and environmental sourcesAspergillusAntifungal SusceptibilityClinicalEnvironmentAntifungal AgentAspergillus SiliconDioxide FowlsDomesticInfecções Sistémicas e ZoonosesSome environmental Aspergillus spp. isolates have been described as resistant to antifungals, potentially causing an emerging medical problem. In the present work, the antifungal susceptibility profile of 41 clinical and 134 environmental isolates of Aspergillus was determined using the CLSI microdilution method. The aim of this study was to compare environmental and clinical isolates with respect to their susceptibility, and assess the potential implications for therapy of isolates encountered in different environments. To our knowledge, this is the first report comparing antifungal susceptibility profiles of Aspergillus collected from different environmental sources (poultries, swineries, beach sand, and hospital environment). Significant differences were found in the distribution of the different species sections for the different sources. Significant differences were also found in the susceptibility profile of the different Aspergillus sections recovered from the various sources. Clear differences were found between the susceptibility of clinical and environmental isolates for caspofungin, amphotericin B and posaconazole, with clinical isolates showing overall greater susceptibility, except for caspofungin. In comparison to clinical isolates, hospital environmental isolates showed significantly less susceptibility to amphotericin B and posaconazole. These data indicate that species section identity and the site from which the isolate was recovered influence the antifungal susceptibility profile, which may affect initial antifungal choices.Raquel Sabino was financially supported by a fellowship from Fundação para a Ciência e Tecnologia (FCT) Portugal (contract ˆSFRH/BPD/72775/2010).Oxford University Press/International Society for Human and Animal Mycology (ISHAM)Repositório Científico do Instituto Nacional de SaúdeSabino, RaquelCarolino, ElisabeteVeríssimo, CristinaMartinez, MarifeClemons, Karl V.Stevens, David A.2017-02-21T11:45:25Z2016-10-012016-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/4302engMed Mycol. 2016 Oct 1;54(7):740-56. doi: 10.1093/mmy/myw024. Epub 2016 May 31369-378610.1093/mmy/myw024info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:01Zoai:repositorio.insa.pt:10400.18/4302Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:38:43.297716Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Antifungal susceptibility of 175 Aspergillus isolates from various clinical and environmental sources |
title |
Antifungal susceptibility of 175 Aspergillus isolates from various clinical and environmental sources |
spellingShingle |
Antifungal susceptibility of 175 Aspergillus isolates from various clinical and environmental sources Sabino, Raquel Aspergillus Antifungal Susceptibility Clinical Environment Antifungal Agent Aspergillus Silicon Dioxide Fowls Domestic Infecções Sistémicas e Zoonoses |
title_short |
Antifungal susceptibility of 175 Aspergillus isolates from various clinical and environmental sources |
title_full |
Antifungal susceptibility of 175 Aspergillus isolates from various clinical and environmental sources |
title_fullStr |
Antifungal susceptibility of 175 Aspergillus isolates from various clinical and environmental sources |
title_full_unstemmed |
Antifungal susceptibility of 175 Aspergillus isolates from various clinical and environmental sources |
title_sort |
Antifungal susceptibility of 175 Aspergillus isolates from various clinical and environmental sources |
author |
Sabino, Raquel |
author_facet |
Sabino, Raquel Carolino, Elisabete Veríssimo, Cristina Martinez, Marife Clemons, Karl V. Stevens, David A. |
author_role |
author |
author2 |
Carolino, Elisabete Veríssimo, Cristina Martinez, Marife Clemons, Karl V. Stevens, David A. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Sabino, Raquel Carolino, Elisabete Veríssimo, Cristina Martinez, Marife Clemons, Karl V. Stevens, David A. |
dc.subject.por.fl_str_mv |
Aspergillus Antifungal Susceptibility Clinical Environment Antifungal Agent Aspergillus Silicon Dioxide Fowls Domestic Infecções Sistémicas e Zoonoses |
topic |
Aspergillus Antifungal Susceptibility Clinical Environment Antifungal Agent Aspergillus Silicon Dioxide Fowls Domestic Infecções Sistémicas e Zoonoses |
description |
Some environmental Aspergillus spp. isolates have been described as resistant to antifungals, potentially causing an emerging medical problem. In the present work, the antifungal susceptibility profile of 41 clinical and 134 environmental isolates of Aspergillus was determined using the CLSI microdilution method. The aim of this study was to compare environmental and clinical isolates with respect to their susceptibility, and assess the potential implications for therapy of isolates encountered in different environments. To our knowledge, this is the first report comparing antifungal susceptibility profiles of Aspergillus collected from different environmental sources (poultries, swineries, beach sand, and hospital environment). Significant differences were found in the distribution of the different species sections for the different sources. Significant differences were also found in the susceptibility profile of the different Aspergillus sections recovered from the various sources. Clear differences were found between the susceptibility of clinical and environmental isolates for caspofungin, amphotericin B and posaconazole, with clinical isolates showing overall greater susceptibility, except for caspofungin. In comparison to clinical isolates, hospital environmental isolates showed significantly less susceptibility to amphotericin B and posaconazole. These data indicate that species section identity and the site from which the isolate was recovered influence the antifungal susceptibility profile, which may affect initial antifungal choices. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-10-01 2016-10-01T00:00:00Z 2017-02-21T11:45:25Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/4302 |
url |
http://hdl.handle.net/10400.18/4302 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Med Mycol. 2016 Oct 1;54(7):740-56. doi: 10.1093/mmy/myw024. Epub 2016 May 3 1369-3786 10.1093/mmy/myw024 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Oxford University Press/International Society for Human and Animal Mycology (ISHAM) |
publisher.none.fl_str_mv |
Oxford University Press/International Society for Human and Animal Mycology (ISHAM) |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799132124862742528 |