HLA complex: brief history, general characterization and impact on kidney transplantation

Detalhes bibliográficos
Autor(a) principal: Martins, Miguel Fernandes Rodrigues Simões
Data de Publicação: 2016
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/37099
Resumo: Trabalho final do 6º ano médico com vista à atribuição do grau de mestre (área científica de nefrologia) no âmbito do ciclo de estudos de Mestrado Integrado em Medicina.
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spelling HLA complex: brief history, general characterization and impact on kidney transplantationMajor Histocompatibility ComplexHLA antigens,Renal transplantationHistorical aspectsGraft rejectionNon-HLA antigensHistocompatibility TestingTrabalho final do 6º ano médico com vista à atribuição do grau de mestre (área científica de nefrologia) no âmbito do ciclo de estudos de Mestrado Integrado em Medicina.Since the beginning of renal transplantation, the incompatibility of tissues between donor and recipient is known to be one the key barriers to a successful procedure, predisposing significantly to rejection episodes. The importance of human Major Histocompatibility Complex (MHC)/Human Leukocyte Antigen (HLA) complex in kidney transplantation, is reviewed in this article. The chosen articles reveal the most important moments and achievements in this field, since the beginning of the 20th century. This review is divided in four major topics, which englobe the main goals of this article: the history behind the discovery of the HLA; the general characterization of the HLA complex, emphasizing the relevant aspects of HLA-class I and HLA-class II structure, genetics and main functions; the impact of the HLA complex matching in kidney transplantation, including an explanation of its mechanisms and role in hyperacute rejection, cell-mediated acute rejection, antibody-mediated acute rejection and chronic allograft dysfunction; the more recent aspects on how to proceed to the immunological study of a patient before, during and after a renal transplantation, discussing the pros and cons of each step and techniques used, and the newest discoveries in the field. The progress achieved in understanding the link between HLA complex and renal transplantation has been shown to radically improve graft survival and to reduce the incidence of rejection episodes. However, there is still a long way to improve, as the impact of the non- HLA antigens remains misunderstood and as more efficient methods to study the patients still under discussion.2016-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesishttp://hdl.handle.net/10316/37099http://hdl.handle.net/10316/37099engMartins, Miguel Fernandes Rodrigues Simõesinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-01-20T17:48:45Zoai:estudogeral.uc.pt:10316/37099Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:44:04.238300Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv HLA complex: brief history, general characterization and impact on kidney transplantation
title HLA complex: brief history, general characterization and impact on kidney transplantation
spellingShingle HLA complex: brief history, general characterization and impact on kidney transplantation
Martins, Miguel Fernandes Rodrigues Simões
Major Histocompatibility Complex
HLA antigens,
Renal transplantation
Historical aspects
Graft rejection
Non-HLA antigens
Histocompatibility Testing
title_short HLA complex: brief history, general characterization and impact on kidney transplantation
title_full HLA complex: brief history, general characterization and impact on kidney transplantation
title_fullStr HLA complex: brief history, general characterization and impact on kidney transplantation
title_full_unstemmed HLA complex: brief history, general characterization and impact on kidney transplantation
title_sort HLA complex: brief history, general characterization and impact on kidney transplantation
author Martins, Miguel Fernandes Rodrigues Simões
author_facet Martins, Miguel Fernandes Rodrigues Simões
author_role author
dc.contributor.author.fl_str_mv Martins, Miguel Fernandes Rodrigues Simões
dc.subject.por.fl_str_mv Major Histocompatibility Complex
HLA antigens,
Renal transplantation
Historical aspects
Graft rejection
Non-HLA antigens
Histocompatibility Testing
topic Major Histocompatibility Complex
HLA antigens,
Renal transplantation
Historical aspects
Graft rejection
Non-HLA antigens
Histocompatibility Testing
description Trabalho final do 6º ano médico com vista à atribuição do grau de mestre (área científica de nefrologia) no âmbito do ciclo de estudos de Mestrado Integrado em Medicina.
publishDate 2016
dc.date.none.fl_str_mv 2016-03
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/37099
http://hdl.handle.net/10316/37099
url http://hdl.handle.net/10316/37099
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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