Nanoparticles for Delivery of Vitamin D: Challenges and Opportunities
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , |
Tipo de documento: | Livro |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/116166 |
Resumo: | In addition to the traditional role of calcium homeostasis and bone mineralization, calcitriol, the active metabolite of vitamin D, also displays other metabolic activities as antiproliferative, proȬd fferent at ngǰ ant Ȭ nflammatoryǰ immunomodulatory, and antineoplastic effectsǯ Thus, the awareness that vitamin D nsuffic encyȦdefic ency may be associated with various diseases has grown. Also nowadays, vitamin D is recognized as a potential therapeutic agent in anticancer therapy. However, its administration presents some drawbacks such as high toxicity and low bioavailability. Thus, the use of nanotechnology may overcome these problems associated with vitamin D administra‐ tion, allowing to decrease its toxicity in healthy tissues and increasing its bioavailability. In this chapter, an overview on vitamin D and its metabolic activity is presented, as well as a review of nanosystems forthe encapsulation of vitamin D for d fferent applications, such as food and pharmaceutical industries |
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Nanoparticles for Delivery of Vitamin D: Challenges and OpportunitiesIn addition to the traditional role of calcium homeostasis and bone mineralization, calcitriol, the active metabolite of vitamin D, also displays other metabolic activities as antiproliferative, proȬd fferent at ngǰ ant Ȭ nflammatoryǰ immunomodulatory, and antineoplastic effectsǯ Thus, the awareness that vitamin D nsuffic encyȦdefic ency may be associated with various diseases has grown. Also nowadays, vitamin D is recognized as a potential therapeutic agent in anticancer therapy. However, its administration presents some drawbacks such as high toxicity and low bioavailability. Thus, the use of nanotechnology may overcome these problems associated with vitamin D administra‐ tion, allowing to decrease its toxicity in healthy tissues and increasing its bioavailability. In this chapter, an overview on vitamin D and its metabolic activity is presented, as well as a review of nanosystems forthe encapsulation of vitamin D for d fferent applications, such as food and pharmaceutical industries20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookapplication/pdfhttps://hdl.handle.net/10216/116166engMaria J. RamalhoManuel A. N. CoelhoMaria do Carmo Pereirainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T15:19:05Zoai:repositorio-aberto.up.pt:10216/116166Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:20:31.659070Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Nanoparticles for Delivery of Vitamin D: Challenges and Opportunities |
title |
Nanoparticles for Delivery of Vitamin D: Challenges and Opportunities |
spellingShingle |
Nanoparticles for Delivery of Vitamin D: Challenges and Opportunities Maria J. Ramalho |
title_short |
Nanoparticles for Delivery of Vitamin D: Challenges and Opportunities |
title_full |
Nanoparticles for Delivery of Vitamin D: Challenges and Opportunities |
title_fullStr |
Nanoparticles for Delivery of Vitamin D: Challenges and Opportunities |
title_full_unstemmed |
Nanoparticles for Delivery of Vitamin D: Challenges and Opportunities |
title_sort |
Nanoparticles for Delivery of Vitamin D: Challenges and Opportunities |
author |
Maria J. Ramalho |
author_facet |
Maria J. Ramalho Manuel A. N. Coelho Maria do Carmo Pereira |
author_role |
author |
author2 |
Manuel A. N. Coelho Maria do Carmo Pereira |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Maria J. Ramalho Manuel A. N. Coelho Maria do Carmo Pereira |
description |
In addition to the traditional role of calcium homeostasis and bone mineralization, calcitriol, the active metabolite of vitamin D, also displays other metabolic activities as antiproliferative, proȬd fferent at ngǰ ant Ȭ nflammatoryǰ immunomodulatory, and antineoplastic effectsǯ Thus, the awareness that vitamin D nsuffic encyȦdefic ency may be associated with various diseases has grown. Also nowadays, vitamin D is recognized as a potential therapeutic agent in anticancer therapy. However, its administration presents some drawbacks such as high toxicity and low bioavailability. Thus, the use of nanotechnology may overcome these problems associated with vitamin D administra‐ tion, allowing to decrease its toxicity in healthy tissues and increasing its bioavailability. In this chapter, an overview on vitamin D and its metabolic activity is presented, as well as a review of nanosystems forthe encapsulation of vitamin D for d fferent applications, such as food and pharmaceutical industries |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/book |
format |
book |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/116166 |
url |
https://hdl.handle.net/10216/116166 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799136121949519872 |