Organic salts based on isoniazid drug: Synthesis, bioavailability and cytotoxicity studies

Detalhes bibliográficos
Autor(a) principal: Santos, Filipa
Data de Publicação: 2020
Outros Autores: Branco, Luís C., Duarte, Ana Rita C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/121299
Resumo: UIDB/50006/2020 POCI-01-0145-FEDER?007265 PTDC/QUI-QOR/32406/2017 MAR-02.01.01-FEAMP-0042
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spelling Organic salts based on isoniazid drug: Synthesis, bioavailability and cytotoxicity studiesBioavailabilityCytotoxicityIonic liquids & organic saltsIsoniazidTuberculosisPharmaceutical ScienceSDG 3 - Good Health and Well-beingUIDB/50006/2020 POCI-01-0145-FEDER?007265 PTDC/QUI-QOR/32406/2017 MAR-02.01.01-FEAMP-0042Tuberculosis is one of the ten causes of morbidity and mortality worldwide caused by Mycobacterium tuberculosis complex. Some of the anti-tuberculosis drugs used in clinic studies, despite being effective for the treatment of tuberculosis, present serious adverse effects as well as poor bioavailability, stability, and drug-resistance problems. Thus, it is important to develop approaches that could provide shorter drug regimens, preventing drug resistance, toxicity of the antibiotics, and improve their bioavailability. Herein, we reported the use of organic salts based on the isoniazid drug, which can act as an organic cation combined with suitable organic anions such as alkylsulfonate-based (mesylate, R or S-Camphorsulfonate), carboxylate-based (glycolate, vanylate) and sacharinate. The synthesis, characterization, and cytotoxicity studies comparing with the original isoniazid drug have been performed. The possibility to explore dicationic salts seems promising in order to improve original bioavailability, and promote the elimination of polymorphic forms as well as higher stability, which are relevant characteristics that the pharmaceutical industry pursues.LAQV@REQUIMTEDQ - Departamento de QuímicaRUNSantos, FilipaBranco, Luís C.Duarte, Ana Rita C.2021-07-19T22:17:57Z2020-10-102020-10-10T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article15application/pdfhttp://hdl.handle.net/10362/121299eng1999-4923PURE: 32646123https://doi.org/10.3390/pharmaceutics12100952info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:03:31Zoai:run.unl.pt:10362/121299Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:44:33.331995Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Organic salts based on isoniazid drug: Synthesis, bioavailability and cytotoxicity studies
title Organic salts based on isoniazid drug: Synthesis, bioavailability and cytotoxicity studies
spellingShingle Organic salts based on isoniazid drug: Synthesis, bioavailability and cytotoxicity studies
Santos, Filipa
Bioavailability
Cytotoxicity
Ionic liquids & organic salts
Isoniazid
Tuberculosis
Pharmaceutical Science
SDG 3 - Good Health and Well-being
title_short Organic salts based on isoniazid drug: Synthesis, bioavailability and cytotoxicity studies
title_full Organic salts based on isoniazid drug: Synthesis, bioavailability and cytotoxicity studies
title_fullStr Organic salts based on isoniazid drug: Synthesis, bioavailability and cytotoxicity studies
title_full_unstemmed Organic salts based on isoniazid drug: Synthesis, bioavailability and cytotoxicity studies
title_sort Organic salts based on isoniazid drug: Synthesis, bioavailability and cytotoxicity studies
author Santos, Filipa
author_facet Santos, Filipa
Branco, Luís C.
Duarte, Ana Rita C.
author_role author
author2 Branco, Luís C.
Duarte, Ana Rita C.
author2_role author
author
dc.contributor.none.fl_str_mv LAQV@REQUIMTE
DQ - Departamento de Química
RUN
dc.contributor.author.fl_str_mv Santos, Filipa
Branco, Luís C.
Duarte, Ana Rita C.
dc.subject.por.fl_str_mv Bioavailability
Cytotoxicity
Ionic liquids & organic salts
Isoniazid
Tuberculosis
Pharmaceutical Science
SDG 3 - Good Health and Well-being
topic Bioavailability
Cytotoxicity
Ionic liquids & organic salts
Isoniazid
Tuberculosis
Pharmaceutical Science
SDG 3 - Good Health and Well-being
description UIDB/50006/2020 POCI-01-0145-FEDER?007265 PTDC/QUI-QOR/32406/2017 MAR-02.01.01-FEAMP-0042
publishDate 2020
dc.date.none.fl_str_mv 2020-10-10
2020-10-10T00:00:00Z
2021-07-19T22:17:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/121299
url http://hdl.handle.net/10362/121299
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1999-4923
PURE: 32646123
https://doi.org/10.3390/pharmaceutics12100952
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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