A Key Role for Neurotensin in Chronic-Stress-Induced Anxiety-Like Behavior in Rats

Detalhes bibliográficos
Autor(a) principal: Normandeau, Catherine P.
Data de Publicação: 2018
Outros Autores: Silva, Ana Paula Ventura, Hawken, Emily R., Angelis, Staci, Sjaarda, Calvin, Liu, Xudong, Pêgo, José M., Dumont, É. C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/57920
Resumo: Accepted Manuscript
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spelling A Key Role for Neurotensin in Chronic-Stress-Induced Anxiety-Like Behavior in RatsAnimalsBehavior, AnimalChronic DiseaseCorticotropin-Releasing HormoneDisease Models, AnimalNeural InhibitionNeuronsNeurotensinRatsRats, Long-EvansRats, WistarReceptors, NeurotensinSynaptic TransmissionAnxietySeptal NucleiStress, PsychologicalCiências Médicas::Medicina BásicaScience & TechnologyAccepted ManuscriptChronic stress is a major cause of anxiety disorders that can be reliably modeled preclinically, providing insight into alternative therapeutic targets for this mental health illness. Neuropeptides have been targeted in the past to no avail possibly due to our lack of understanding of their role in pathological models. In this study we use a rat model of chronic stress-induced anxiety-like behaviors and hypothesized that neuropeptidergic modulation of synaptic transmission would be altered in the bed nucleus of the stria terminalis (BNST), a brain region suspected to contribute to anxiety disorders. We use brain slice neurophysiology and behavioral pharmacology to compare the role of locally released endogenous neuropeptides on synaptic transmission in the oval (ov) BNST of non-stressed (NS) or chronic unpredictably stressed (CUS) rats. We found that in NS rats, post-synaptic depolarization induced the release of vesicular neurotensin (NT) and corticotropin-releasing factor (CRF) that co-acted to increase ovBNST inhibitory synaptic transmission in 59% of recorded neurons. CUS bolstered this potentiation (100% of recorded neurons) through an enhanced contribution of NT over CRF. In contrast, locally released opioid neuropeptides decreased ovBNST excitatory synaptic transmission in all recorded neurons, regardless of stress. Consistent with CUS-induced enhanced modulatory effects of NT, blockade of ovBNST NT receptors completely abolished stress-induced anxiety-like behaviors in the elevated plus maze paradigm. The role of NT has been largely unexplored in stress and our findings highlight its potential contribution to an important behavioral consequence of chronic stress, that is, exaggerated avoidance of open space in rats.CPN was funded by CIHR Vanier Graduate Scholarship (338319); APVS was funded by Fundação para a Ciência e Tecnologia (SFRH/BPD/52078/2013); ERH was funded by CIHR Postdoctoral Fellowship (MFE-123712); SA was funded by a Queen Elizabeth II Graduate Scholarship in Science and Technology; ÉCD was funded by the Canadian Institute of Health Research (MOP-25953)info:eu-repo/semantics/publishedVersionSpringer NatureUniversidade do MinhoNormandeau, Catherine P.Silva, Ana Paula VenturaHawken, Emily R.Angelis, StaciSjaarda, CalvinLiu, XudongPêgo, José M.Dumont, É. C.2018-012018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/57920engNormandeau, C. P., Ventura-Silva, A. P., Hawken, E. R., Angelis, S., et. al.(2018). A key role for neurotensin in chronic-stress-induced anxiety-like behavior in rats. Neuropsychopharmacology, 43(2), 2851740-634X10.1038/npp.2017.13428649992https://www.nature.com/articles/npp2017134info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-11T06:53:33Zoai:repositorium.sdum.uminho.pt:1822/57920Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-11T06:53:33Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A Key Role for Neurotensin in Chronic-Stress-Induced Anxiety-Like Behavior in Rats
title A Key Role for Neurotensin in Chronic-Stress-Induced Anxiety-Like Behavior in Rats
spellingShingle A Key Role for Neurotensin in Chronic-Stress-Induced Anxiety-Like Behavior in Rats
Normandeau, Catherine P.
Animals
Behavior, Animal
Chronic Disease
Corticotropin-Releasing Hormone
Disease Models, Animal
Neural Inhibition
Neurons
Neurotensin
Rats
Rats, Long-Evans
Rats, Wistar
Receptors, Neurotensin
Synaptic Transmission
Anxiety
Septal Nuclei
Stress, Psychological
Ciências Médicas::Medicina Básica
Science & Technology
title_short A Key Role for Neurotensin in Chronic-Stress-Induced Anxiety-Like Behavior in Rats
title_full A Key Role for Neurotensin in Chronic-Stress-Induced Anxiety-Like Behavior in Rats
title_fullStr A Key Role for Neurotensin in Chronic-Stress-Induced Anxiety-Like Behavior in Rats
title_full_unstemmed A Key Role for Neurotensin in Chronic-Stress-Induced Anxiety-Like Behavior in Rats
title_sort A Key Role for Neurotensin in Chronic-Stress-Induced Anxiety-Like Behavior in Rats
author Normandeau, Catherine P.
author_facet Normandeau, Catherine P.
Silva, Ana Paula Ventura
Hawken, Emily R.
Angelis, Staci
Sjaarda, Calvin
Liu, Xudong
Pêgo, José M.
Dumont, É. C.
author_role author
author2 Silva, Ana Paula Ventura
Hawken, Emily R.
Angelis, Staci
Sjaarda, Calvin
Liu, Xudong
Pêgo, José M.
Dumont, É. C.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Normandeau, Catherine P.
Silva, Ana Paula Ventura
Hawken, Emily R.
Angelis, Staci
Sjaarda, Calvin
Liu, Xudong
Pêgo, José M.
Dumont, É. C.
dc.subject.por.fl_str_mv Animals
Behavior, Animal
Chronic Disease
Corticotropin-Releasing Hormone
Disease Models, Animal
Neural Inhibition
Neurons
Neurotensin
Rats
Rats, Long-Evans
Rats, Wistar
Receptors, Neurotensin
Synaptic Transmission
Anxiety
Septal Nuclei
Stress, Psychological
Ciências Médicas::Medicina Básica
Science & Technology
topic Animals
Behavior, Animal
Chronic Disease
Corticotropin-Releasing Hormone
Disease Models, Animal
Neural Inhibition
Neurons
Neurotensin
Rats
Rats, Long-Evans
Rats, Wistar
Receptors, Neurotensin
Synaptic Transmission
Anxiety
Septal Nuclei
Stress, Psychological
Ciências Médicas::Medicina Básica
Science & Technology
description Accepted Manuscript
publishDate 2018
dc.date.none.fl_str_mv 2018-01
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/57920
url http://hdl.handle.net/1822/57920
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Normandeau, C. P., Ventura-Silva, A. P., Hawken, E. R., Angelis, S., et. al.(2018). A key role for neurotensin in chronic-stress-induced anxiety-like behavior in rats. Neuropsychopharmacology, 43(2), 285
1740-634X
10.1038/npp.2017.134
28649992
https://www.nature.com/articles/npp2017134
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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