Additional value of associating aortic valve calcification to coronary calcium as a gatekeeper for coronary tomography angiography
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/109075 https://doi.org/10.1186/s12872-015-0058-5 |
Resumo: | Background: Aortic valve calcification shares risk factors with coronary artery disease. Coronary calcium has been used has a gatekeeper to performing coronary tomography angiography. The aim of this study was to evaluate aortic valve calcification as a predictor of obstructive coronary artery disease by computed tomography, and its possible usefulness, alongside with coronary calcium, to improve the decision of whether or not to proceed with computed tomography angiography. Methods: Transversal case–control study including 154 consecutive patients (62 ± 12 years, 57.6 % female, without known coronary or valve disease) undergoing calcium scoring and angiography through computed tomography (Phillips Brilliance, 16-slice). Predictors of aortic valve calcification and obstructive coronary artery disease were identified. Usefulness of aortic valve calcification when added to calcium score for prediction of obstructive coronary artery disease was assessed by binary logistic regression and net reclassification index. Results: Aortic valve calcification was associated with higher coronary calcium, extent and prevalence of obstructive coronary disease, which was identified in 22.1 % of patients and was discriminated by aortic valve calcium with an area under curve 0.749 (p < 0.001, Youden index: 61). A higher discriminative power was achieved with a model based on coronary and aortic valve calcification (AUC 0.900, p < 0.001). Compared with calcium score >400 as a gatekeeper to angiography, the association of aortic calcium >61 allowed a net reclassification index of +7.7 % of patients. Conclusions: Aortic valve calcification is associated with the prevalence and extent of obstructive coronary artery disease by computed tomography angiography and is an easy, fast and useful method to improve the selection of patients for angiography. |
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Additional value of associating aortic valve calcification to coronary calcium as a gatekeeper for coronary tomography angiographyAortic valve calcificationCardiac computed tomographyCoronary artery calcificationCoronary artery diseaseCoronary CT angiographyAgedAortic ValveAortic Valve StenosisBicuspid Aortic Valve DiseaseCalcinosisCase-Control StudiesCohort StudiesCoronary AngiographyCoronary Artery DiseaseCoronary StenosisFemaleHeart Defects, CongenitalHeart Valve DiseasesHumansLogistic ModelsMaleMiddle AgedRetrospective StudiesTomography, X-Ray ComputedVascular CalcificationBackground: Aortic valve calcification shares risk factors with coronary artery disease. Coronary calcium has been used has a gatekeeper to performing coronary tomography angiography. The aim of this study was to evaluate aortic valve calcification as a predictor of obstructive coronary artery disease by computed tomography, and its possible usefulness, alongside with coronary calcium, to improve the decision of whether or not to proceed with computed tomography angiography. Methods: Transversal case–control study including 154 consecutive patients (62 ± 12 years, 57.6 % female, without known coronary or valve disease) undergoing calcium scoring and angiography through computed tomography (Phillips Brilliance, 16-slice). Predictors of aortic valve calcification and obstructive coronary artery disease were identified. Usefulness of aortic valve calcification when added to calcium score for prediction of obstructive coronary artery disease was assessed by binary logistic regression and net reclassification index. Results: Aortic valve calcification was associated with higher coronary calcium, extent and prevalence of obstructive coronary disease, which was identified in 22.1 % of patients and was discriminated by aortic valve calcium with an area under curve 0.749 (p < 0.001, Youden index: 61). A higher discriminative power was achieved with a model based on coronary and aortic valve calcification (AUC 0.900, p < 0.001). Compared with calcium score >400 as a gatekeeper to angiography, the association of aortic calcium >61 allowed a net reclassification index of +7.7 % of patients. Conclusions: Aortic valve calcification is associated with the prevalence and extent of obstructive coronary artery disease by computed tomography angiography and is an easy, fast and useful method to improve the selection of patients for angiography.Springer Nature2015-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/109075http://hdl.handle.net/10316/109075https://doi.org/10.1186/s12872-015-0058-5eng1471-2261Faustino, AnaProvidência, RuiPaiva, LuísCatarino, RuiBasso, SusanaCosta, MarcoGonçalves, Linoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-27T07:36:50Zoai:estudogeral.uc.pt:10316/109075Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:25:17.125662Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Additional value of associating aortic valve calcification to coronary calcium as a gatekeeper for coronary tomography angiography |
title |
Additional value of associating aortic valve calcification to coronary calcium as a gatekeeper for coronary tomography angiography |
spellingShingle |
Additional value of associating aortic valve calcification to coronary calcium as a gatekeeper for coronary tomography angiography Faustino, Ana Aortic valve calcification Cardiac computed tomography Coronary artery calcification Coronary artery disease Coronary CT angiography Aged Aortic Valve Aortic Valve Stenosis Bicuspid Aortic Valve Disease Calcinosis Case-Control Studies Cohort Studies Coronary Angiography Coronary Artery Disease Coronary Stenosis Female Heart Defects, Congenital Heart Valve Diseases Humans Logistic Models Male Middle Aged Retrospective Studies Tomography, X-Ray Computed Vascular Calcification |
title_short |
Additional value of associating aortic valve calcification to coronary calcium as a gatekeeper for coronary tomography angiography |
title_full |
Additional value of associating aortic valve calcification to coronary calcium as a gatekeeper for coronary tomography angiography |
title_fullStr |
Additional value of associating aortic valve calcification to coronary calcium as a gatekeeper for coronary tomography angiography |
title_full_unstemmed |
Additional value of associating aortic valve calcification to coronary calcium as a gatekeeper for coronary tomography angiography |
title_sort |
Additional value of associating aortic valve calcification to coronary calcium as a gatekeeper for coronary tomography angiography |
author |
Faustino, Ana |
author_facet |
Faustino, Ana Providência, Rui Paiva, Luís Catarino, Rui Basso, Susana Costa, Marco Gonçalves, Lino |
author_role |
author |
author2 |
Providência, Rui Paiva, Luís Catarino, Rui Basso, Susana Costa, Marco Gonçalves, Lino |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Faustino, Ana Providência, Rui Paiva, Luís Catarino, Rui Basso, Susana Costa, Marco Gonçalves, Lino |
dc.subject.por.fl_str_mv |
Aortic valve calcification Cardiac computed tomography Coronary artery calcification Coronary artery disease Coronary CT angiography Aged Aortic Valve Aortic Valve Stenosis Bicuspid Aortic Valve Disease Calcinosis Case-Control Studies Cohort Studies Coronary Angiography Coronary Artery Disease Coronary Stenosis Female Heart Defects, Congenital Heart Valve Diseases Humans Logistic Models Male Middle Aged Retrospective Studies Tomography, X-Ray Computed Vascular Calcification |
topic |
Aortic valve calcification Cardiac computed tomography Coronary artery calcification Coronary artery disease Coronary CT angiography Aged Aortic Valve Aortic Valve Stenosis Bicuspid Aortic Valve Disease Calcinosis Case-Control Studies Cohort Studies Coronary Angiography Coronary Artery Disease Coronary Stenosis Female Heart Defects, Congenital Heart Valve Diseases Humans Logistic Models Male Middle Aged Retrospective Studies Tomography, X-Ray Computed Vascular Calcification |
description |
Background: Aortic valve calcification shares risk factors with coronary artery disease. Coronary calcium has been used has a gatekeeper to performing coronary tomography angiography. The aim of this study was to evaluate aortic valve calcification as a predictor of obstructive coronary artery disease by computed tomography, and its possible usefulness, alongside with coronary calcium, to improve the decision of whether or not to proceed with computed tomography angiography. Methods: Transversal case–control study including 154 consecutive patients (62 ± 12 years, 57.6 % female, without known coronary or valve disease) undergoing calcium scoring and angiography through computed tomography (Phillips Brilliance, 16-slice). Predictors of aortic valve calcification and obstructive coronary artery disease were identified. Usefulness of aortic valve calcification when added to calcium score for prediction of obstructive coronary artery disease was assessed by binary logistic regression and net reclassification index. Results: Aortic valve calcification was associated with higher coronary calcium, extent and prevalence of obstructive coronary disease, which was identified in 22.1 % of patients and was discriminated by aortic valve calcium with an area under curve 0.749 (p < 0.001, Youden index: 61). A higher discriminative power was achieved with a model based on coronary and aortic valve calcification (AUC 0.900, p < 0.001). Compared with calcium score >400 as a gatekeeper to angiography, the association of aortic calcium >61 allowed a net reclassification index of +7.7 % of patients. Conclusions: Aortic valve calcification is associated with the prevalence and extent of obstructive coronary artery disease by computed tomography angiography and is an easy, fast and useful method to improve the selection of patients for angiography. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-07-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/109075 http://hdl.handle.net/10316/109075 https://doi.org/10.1186/s12872-015-0058-5 |
url |
http://hdl.handle.net/10316/109075 https://doi.org/10.1186/s12872-015-0058-5 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1471-2261 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Springer Nature |
publisher.none.fl_str_mv |
Springer Nature |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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