Additional value of associating aortic valve calcification to coronary calcium as a gatekeeper for coronary tomography angiography

Detalhes bibliográficos
Autor(a) principal: Faustino, Ana
Data de Publicação: 2015
Outros Autores: Providência, Rui, Paiva, Luís, Catarino, Rui, Basso, Susana, Costa, Marco, Gonçalves, Lino
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/109075
https://doi.org/10.1186/s12872-015-0058-5
Resumo: Background: Aortic valve calcification shares risk factors with coronary artery disease. Coronary calcium has been used has a gatekeeper to performing coronary tomography angiography. The aim of this study was to evaluate aortic valve calcification as a predictor of obstructive coronary artery disease by computed tomography, and its possible usefulness, alongside with coronary calcium, to improve the decision of whether or not to proceed with computed tomography angiography. Methods: Transversal case–control study including 154 consecutive patients (62 ± 12 years, 57.6 % female, without known coronary or valve disease) undergoing calcium scoring and angiography through computed tomography (Phillips Brilliance, 16-slice). Predictors of aortic valve calcification and obstructive coronary artery disease were identified. Usefulness of aortic valve calcification when added to calcium score for prediction of obstructive coronary artery disease was assessed by binary logistic regression and net reclassification index. Results: Aortic valve calcification was associated with higher coronary calcium, extent and prevalence of obstructive coronary disease, which was identified in 22.1 % of patients and was discriminated by aortic valve calcium with an area under curve 0.749 (p < 0.001, Youden index: 61). A higher discriminative power was achieved with a model based on coronary and aortic valve calcification (AUC 0.900, p < 0.001). Compared with calcium score >400 as a gatekeeper to angiography, the association of aortic calcium >61 allowed a net reclassification index of +7.7 % of patients. Conclusions: Aortic valve calcification is associated with the prevalence and extent of obstructive coronary artery disease by computed tomography angiography and is an easy, fast and useful method to improve the selection of patients for angiography.
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spelling Additional value of associating aortic valve calcification to coronary calcium as a gatekeeper for coronary tomography angiographyAortic valve calcificationCardiac computed tomographyCoronary artery calcificationCoronary artery diseaseCoronary CT angiographyAgedAortic ValveAortic Valve StenosisBicuspid Aortic Valve DiseaseCalcinosisCase-Control StudiesCohort StudiesCoronary AngiographyCoronary Artery DiseaseCoronary StenosisFemaleHeart Defects, CongenitalHeart Valve DiseasesHumansLogistic ModelsMaleMiddle AgedRetrospective StudiesTomography, X-Ray ComputedVascular CalcificationBackground: Aortic valve calcification shares risk factors with coronary artery disease. Coronary calcium has been used has a gatekeeper to performing coronary tomography angiography. The aim of this study was to evaluate aortic valve calcification as a predictor of obstructive coronary artery disease by computed tomography, and its possible usefulness, alongside with coronary calcium, to improve the decision of whether or not to proceed with computed tomography angiography. Methods: Transversal case–control study including 154 consecutive patients (62 ± 12 years, 57.6 % female, without known coronary or valve disease) undergoing calcium scoring and angiography through computed tomography (Phillips Brilliance, 16-slice). Predictors of aortic valve calcification and obstructive coronary artery disease were identified. Usefulness of aortic valve calcification when added to calcium score for prediction of obstructive coronary artery disease was assessed by binary logistic regression and net reclassification index. Results: Aortic valve calcification was associated with higher coronary calcium, extent and prevalence of obstructive coronary disease, which was identified in 22.1 % of patients and was discriminated by aortic valve calcium with an area under curve 0.749 (p < 0.001, Youden index: 61). A higher discriminative power was achieved with a model based on coronary and aortic valve calcification (AUC 0.900, p < 0.001). Compared with calcium score >400 as a gatekeeper to angiography, the association of aortic calcium >61 allowed a net reclassification index of +7.7 % of patients. Conclusions: Aortic valve calcification is associated with the prevalence and extent of obstructive coronary artery disease by computed tomography angiography and is an easy, fast and useful method to improve the selection of patients for angiography.Springer Nature2015-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/109075http://hdl.handle.net/10316/109075https://doi.org/10.1186/s12872-015-0058-5eng1471-2261Faustino, AnaProvidência, RuiPaiva, LuísCatarino, RuiBasso, SusanaCosta, MarcoGonçalves, Linoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-27T07:36:50Zoai:estudogeral.uc.pt:10316/109075Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:25:17.125662Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Additional value of associating aortic valve calcification to coronary calcium as a gatekeeper for coronary tomography angiography
title Additional value of associating aortic valve calcification to coronary calcium as a gatekeeper for coronary tomography angiography
spellingShingle Additional value of associating aortic valve calcification to coronary calcium as a gatekeeper for coronary tomography angiography
Faustino, Ana
Aortic valve calcification
Cardiac computed tomography
Coronary artery calcification
Coronary artery disease
Coronary CT angiography
Aged
Aortic Valve
Aortic Valve Stenosis
Bicuspid Aortic Valve Disease
Calcinosis
Case-Control Studies
Cohort Studies
Coronary Angiography
Coronary Artery Disease
Coronary Stenosis
Female
Heart Defects, Congenital
Heart Valve Diseases
Humans
Logistic Models
Male
Middle Aged
Retrospective Studies
Tomography, X-Ray Computed
Vascular Calcification
title_short Additional value of associating aortic valve calcification to coronary calcium as a gatekeeper for coronary tomography angiography
title_full Additional value of associating aortic valve calcification to coronary calcium as a gatekeeper for coronary tomography angiography
title_fullStr Additional value of associating aortic valve calcification to coronary calcium as a gatekeeper for coronary tomography angiography
title_full_unstemmed Additional value of associating aortic valve calcification to coronary calcium as a gatekeeper for coronary tomography angiography
title_sort Additional value of associating aortic valve calcification to coronary calcium as a gatekeeper for coronary tomography angiography
author Faustino, Ana
author_facet Faustino, Ana
Providência, Rui
Paiva, Luís
Catarino, Rui
Basso, Susana
Costa, Marco
Gonçalves, Lino
author_role author
author2 Providência, Rui
Paiva, Luís
Catarino, Rui
Basso, Susana
Costa, Marco
Gonçalves, Lino
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Faustino, Ana
Providência, Rui
Paiva, Luís
Catarino, Rui
Basso, Susana
Costa, Marco
Gonçalves, Lino
dc.subject.por.fl_str_mv Aortic valve calcification
Cardiac computed tomography
Coronary artery calcification
Coronary artery disease
Coronary CT angiography
Aged
Aortic Valve
Aortic Valve Stenosis
Bicuspid Aortic Valve Disease
Calcinosis
Case-Control Studies
Cohort Studies
Coronary Angiography
Coronary Artery Disease
Coronary Stenosis
Female
Heart Defects, Congenital
Heart Valve Diseases
Humans
Logistic Models
Male
Middle Aged
Retrospective Studies
Tomography, X-Ray Computed
Vascular Calcification
topic Aortic valve calcification
Cardiac computed tomography
Coronary artery calcification
Coronary artery disease
Coronary CT angiography
Aged
Aortic Valve
Aortic Valve Stenosis
Bicuspid Aortic Valve Disease
Calcinosis
Case-Control Studies
Cohort Studies
Coronary Angiography
Coronary Artery Disease
Coronary Stenosis
Female
Heart Defects, Congenital
Heart Valve Diseases
Humans
Logistic Models
Male
Middle Aged
Retrospective Studies
Tomography, X-Ray Computed
Vascular Calcification
description Background: Aortic valve calcification shares risk factors with coronary artery disease. Coronary calcium has been used has a gatekeeper to performing coronary tomography angiography. The aim of this study was to evaluate aortic valve calcification as a predictor of obstructive coronary artery disease by computed tomography, and its possible usefulness, alongside with coronary calcium, to improve the decision of whether or not to proceed with computed tomography angiography. Methods: Transversal case–control study including 154 consecutive patients (62 ± 12 years, 57.6 % female, without known coronary or valve disease) undergoing calcium scoring and angiography through computed tomography (Phillips Brilliance, 16-slice). Predictors of aortic valve calcification and obstructive coronary artery disease were identified. Usefulness of aortic valve calcification when added to calcium score for prediction of obstructive coronary artery disease was assessed by binary logistic regression and net reclassification index. Results: Aortic valve calcification was associated with higher coronary calcium, extent and prevalence of obstructive coronary disease, which was identified in 22.1 % of patients and was discriminated by aortic valve calcium with an area under curve 0.749 (p < 0.001, Youden index: 61). A higher discriminative power was achieved with a model based on coronary and aortic valve calcification (AUC 0.900, p < 0.001). Compared with calcium score >400 as a gatekeeper to angiography, the association of aortic calcium >61 allowed a net reclassification index of +7.7 % of patients. Conclusions: Aortic valve calcification is associated with the prevalence and extent of obstructive coronary artery disease by computed tomography angiography and is an easy, fast and useful method to improve the selection of patients for angiography.
publishDate 2015
dc.date.none.fl_str_mv 2015-07-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/109075
http://hdl.handle.net/10316/109075
https://doi.org/10.1186/s12872-015-0058-5
url http://hdl.handle.net/10316/109075
https://doi.org/10.1186/s12872-015-0058-5
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1471-2261
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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