Maternal methylmercury exposure during early-life periods adversely affects mature enamel structure of offspring rats at human exposure levels
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/164619 |
Resumo: | Funding Information: RL is a researcher from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and received grant under number 312275/2021–8. MC-L is also recognized by the CNPq as highly productive researcher with the grant number 313406/2021–9. Also, this research was funded by PROCAD Amazônia–CAPES (23038.005350/2018–78). The APC was funded by Pró-Reitoria de Pesquisa e Pós-graduação from Federal University of Pará (PROPESP-UFPA). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: Copyright © 2023 Chemelo, Bittencourt, Nascimento, Paiva, Delbem, Pessan, do Espírito Santo, Albuquerque, Angélica, Crespo-Lopez, Pessanha, Aschner and Lima. |
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Maternal methylmercury exposure during early-life periods adversely affects mature enamel structure of offspring rats at human exposure levelsa concern for oral healthdevelopmentenamelmethylmercuryoffspringtoxicityPublic Health, Environmental and Occupational HealthSDG 3 - Good Health and Well-beingFunding Information: RL is a researcher from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and received grant under number 312275/2021–8. MC-L is also recognized by the CNPq as highly productive researcher with the grant number 313406/2021–9. Also, this research was funded by PROCAD Amazônia–CAPES (23038.005350/2018–78). The APC was funded by Pró-Reitoria de Pesquisa e Pós-graduação from Federal University of Pará (PROPESP-UFPA). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: Copyright © 2023 Chemelo, Bittencourt, Nascimento, Paiva, Delbem, Pessan, do Espírito Santo, Albuquerque, Angélica, Crespo-Lopez, Pessanha, Aschner and Lima.Although there are many studies on the health effects of methylmercury (MeHg) toxicity during in utero and early development, little is known about its effects on mineralized tissues present in the oral cavity, such as enamel structure. Therefore, this study evaluated the effects of MeHg exposure on the physico-chemical, ultrastructural and functional properties of mature tooth enamel. Specifically, we studied offspring of mothers exposed to MeHg during the prenatal and postnatal periods which are the developmental stages associated with tooth enamel formation. Female rats were exposed to MeHg at a dose of 40 μg/kg/day for 42 days of pregnancy and lactation. The enamel of offspring was analyzed by (1) Fourier Transform Infrared Spectroscopy and Raman to assess physicochemical composition, (2) Scanning Electron Microscopy for ultrastructural evaluation, (3) Transmitted Polarizing Light Microscopy for analysis of the enamel extracellular matrix, and (4) resistance and hardness were evaluated by microhardness. The results showed that MeHg exposure during this sensitive enamel formation period induced changes in inorganic and organic content and enamel prisms ultrastructure alterations and disturbed the organic extracellular matrix due to a decreased enamel strength. These novel findings establish for the first time that maternal exposure to MeHg pre and postnatal promoted relevant changes in mature enamel of their offspring rats.LIBPhys-UNLRUNChemelo, Victória SantosBittencourt, Leonardo OliveiraNascimento , Priscila CunhaPaiva, Mayra FrassonDelbem, Alberto Carlos BotazzoPessan, Juliano Pelimdo Espírito Santo, Alexandre RibeiroAlbuquerque, Alan Rodrigo LealAngélica, Rômulo SimõesCrespo-Lopez, Maria ElenaPessanha, SofiaAschner, MichaelLima, Rafael Rodrigues2024-03-07T23:59:04Z2023-06-302023-06-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12application/pdfhttp://hdl.handle.net/10362/164619eng2296-2565PURE: 84310451https://doi.org/10.3389/fpubh.2023.1183308info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:53:28Zoai:run.unl.pt:10362/164619Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T04:00:17.074219Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Maternal methylmercury exposure during early-life periods adversely affects mature enamel structure of offspring rats at human exposure levels a concern for oral health |
| title |
Maternal methylmercury exposure during early-life periods adversely affects mature enamel structure of offspring rats at human exposure levels |
| spellingShingle |
Maternal methylmercury exposure during early-life periods adversely affects mature enamel structure of offspring rats at human exposure levels Chemelo, Victória Santos development enamel methylmercury offspring toxicity Public Health, Environmental and Occupational Health SDG 3 - Good Health and Well-being |
| title_short |
Maternal methylmercury exposure during early-life periods adversely affects mature enamel structure of offspring rats at human exposure levels |
| title_full |
Maternal methylmercury exposure during early-life periods adversely affects mature enamel structure of offspring rats at human exposure levels |
| title_fullStr |
Maternal methylmercury exposure during early-life periods adversely affects mature enamel structure of offspring rats at human exposure levels |
| title_full_unstemmed |
Maternal methylmercury exposure during early-life periods adversely affects mature enamel structure of offspring rats at human exposure levels |
| title_sort |
Maternal methylmercury exposure during early-life periods adversely affects mature enamel structure of offspring rats at human exposure levels |
| author |
Chemelo, Victória Santos |
| author_facet |
Chemelo, Victória Santos Bittencourt, Leonardo Oliveira Nascimento , Priscila Cunha Paiva, Mayra Frasson Delbem, Alberto Carlos Botazzo Pessan, Juliano Pelim do Espírito Santo, Alexandre Ribeiro Albuquerque, Alan Rodrigo Leal Angélica, Rômulo Simões Crespo-Lopez, Maria Elena Pessanha, Sofia Aschner, Michael Lima, Rafael Rodrigues |
| author_role |
author |
| author2 |
Bittencourt, Leonardo Oliveira Nascimento , Priscila Cunha Paiva, Mayra Frasson Delbem, Alberto Carlos Botazzo Pessan, Juliano Pelim do Espírito Santo, Alexandre Ribeiro Albuquerque, Alan Rodrigo Leal Angélica, Rômulo Simões Crespo-Lopez, Maria Elena Pessanha, Sofia Aschner, Michael Lima, Rafael Rodrigues |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
LIBPhys-UNL RUN |
| dc.contributor.author.fl_str_mv |
Chemelo, Victória Santos Bittencourt, Leonardo Oliveira Nascimento , Priscila Cunha Paiva, Mayra Frasson Delbem, Alberto Carlos Botazzo Pessan, Juliano Pelim do Espírito Santo, Alexandre Ribeiro Albuquerque, Alan Rodrigo Leal Angélica, Rômulo Simões Crespo-Lopez, Maria Elena Pessanha, Sofia Aschner, Michael Lima, Rafael Rodrigues |
| dc.subject.por.fl_str_mv |
development enamel methylmercury offspring toxicity Public Health, Environmental and Occupational Health SDG 3 - Good Health and Well-being |
| topic |
development enamel methylmercury offspring toxicity Public Health, Environmental and Occupational Health SDG 3 - Good Health and Well-being |
| description |
Funding Information: RL is a researcher from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and received grant under number 312275/2021–8. MC-L is also recognized by the CNPq as highly productive researcher with the grant number 313406/2021–9. Also, this research was funded by PROCAD Amazônia–CAPES (23038.005350/2018–78). The APC was funded by Pró-Reitoria de Pesquisa e Pós-graduação from Federal University of Pará (PROPESP-UFPA). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: Copyright © 2023 Chemelo, Bittencourt, Nascimento, Paiva, Delbem, Pessan, do Espírito Santo, Albuquerque, Angélica, Crespo-Lopez, Pessanha, Aschner and Lima. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-06-30 2023-06-30T00:00:00Z 2024-03-07T23:59:04Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/164619 |
| url |
http://hdl.handle.net/10362/164619 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2296-2565 PURE: 84310451 https://doi.org/10.3389/fpubh.2023.1183308 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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12 application/pdf |
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