HIV associated nephropathy with massive polyclonal hypergammaglobulinaemia

• Autor(a) principal: Rebocho, Luísa
• Data de Publicação: 1997
• Outros Autores: Almeida, Amélia, Lucas, Margarida, Victorino, Rui M. M.
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://revista.spmi.pt/index.php/rpmi/article/view/2246
• topic: infecção pelo VIH; nefropatia associada ao VIH; sindrome nefrótico; SIDA; Hipergamalobulinémia; HIV infection; HIV nephropathy; AIDS; hypergammaglobulinamia,; nephrotic syn­drome

A particular form of renal disease in patients infected with the human immunodeficiency vi­rus (HIV) is the HIV-associated nephropathy. It is important to consider this entity in the di­fferential diagnosis of renal disease in these patients. This condition is usually characterized by a severe proteinuri rapid progression to end-stage renal disease, with the most typical patho­logic alteration being focal segmentai glomeru­losclerosis. We describe here a coloured patient with HIV infection who presented with nephrotic syndrome. The patient exhibited a massive form of polyclonal hypergammaglobulinacemia (IgG 71 g/l) and the renal biopsy showed a focal and segmental glomerulosclerosis. The possible ae­tiopathogenesis of this picture is discussed.