Infusions of gamma irradiated Aloysia citrodora L. and Mentha x piperita L.: Effects on phenolic composition, cytotoxicity, antibacterial and virucidal activities

Detalhes bibliográficos
Autor(a) principal: Pereira, Eliana
Data de Publicação: 2017
Outros Autores: Pimenta, Andreia I., Calhelha, Ricardo C., Antonio, Amilcar L., Barros, Lillian, Santos-Buelga, Celestino, Cabo Verde, Sandra, Ferreira, Isabel C.F.R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10198/15306
Resumo: The incorporation of plants in industry requires high standards of hygiene, being the raw materials obligatorily decontaminated. Irradiation is increasingly applied as a decontamination technique in several countries. This work aimed to evaluate the effects of gamma radiation on the phenolic composition, cytotoxicity, virucidal and antimicrobial properties of Aloysia citrodora L. (lemon verbena) and Mentha x piperita L. (peppermint) infusions. Phenolic compounds profile was obtained by HPLC-DAD-ESI/MS and cytotoxicity was ev aluated in human tumour and non-tumour cell lines; in virucidal efficacy, MNV-1 and HAdV-5 viral titers were determined by plaque assay in Raw264.7 and A549 cell lines, respectively; and the antibacterial potential was evaluated against Gram-negative and Gram-positive bacteria. Radiation treatment caused a significant increase in total phenolic compounds of both plants, while the virucidal efficacy was depend on the plant, the virus, and absorbed dose. S. aureus, with MIC and MBC values of 5 mg/mL, was the only bacteria sensible to the infusions of non-irradiated and 1 kGy irradiated lemon verbena and peppermint samples; gamma radiation appears to cause no alteration in the antibacterial potential of the studied plants. Peppermint infusion (irradiated at 10 kGy) showed the highest cytotoxic potential in all tumour cell lines.
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spelling Infusions of gamma irradiated Aloysia citrodora L. and Mentha x piperita L.: Effects on phenolic composition, cytotoxicity, antibacterial and virucidal activitiesAntibacterial activityAromatic herbsCytotoxicityGamma-radiationPhenolic compoundsVirucidal activityThe incorporation of plants in industry requires high standards of hygiene, being the raw materials obligatorily decontaminated. Irradiation is increasingly applied as a decontamination technique in several countries. This work aimed to evaluate the effects of gamma radiation on the phenolic composition, cytotoxicity, virucidal and antimicrobial properties of Aloysia citrodora L. (lemon verbena) and Mentha x piperita L. (peppermint) infusions. Phenolic compounds profile was obtained by HPLC-DAD-ESI/MS and cytotoxicity was ev aluated in human tumour and non-tumour cell lines; in virucidal efficacy, MNV-1 and HAdV-5 viral titers were determined by plaque assay in Raw264.7 and A549 cell lines, respectively; and the antibacterial potential was evaluated against Gram-negative and Gram-positive bacteria. Radiation treatment caused a significant increase in total phenolic compounds of both plants, while the virucidal efficacy was depend on the plant, the virus, and absorbed dose. S. aureus, with MIC and MBC values of 5 mg/mL, was the only bacteria sensible to the infusions of non-irradiated and 1 kGy irradiated lemon verbena and peppermint samples; gamma radiation appears to cause no alteration in the antibacterial potential of the studied plants. Peppermint infusion (irradiated at 10 kGy) showed the highest cytotoxic potential in all tumour cell lines.The authors are grateful to the Foundation for Science andTechnology (FCT, Portugal) and FEDER under Programe PT2020for financial support to CIMO (UID/AGR/00690/2013), LSRE(Project UID/EQU/50020/2013), C2TN (RECI/AAG-TEC/0400/2012;UID/Multi/04349/2013), L. Barros (SFRH/BPD/107855/2015) andR.C. Calhelha (SFRH/BPD/BPD/68344/2010) grants. The authors arealso grateful to Ministry of Agriculture, Portugal (Project AROMAP– PRODER/FEADER/EU), for financial support of the work and E.Pereira and Andreia I. Pimenta grants, and to “MaisErvas – Aromáti-cas e Medicinais” company for providing the samples.Biblioteca Digital do IPBPereira, ElianaPimenta, Andreia I.Calhelha, Ricardo C.Antonio, Amilcar L.Barros, LillianSantos-Buelga, CelestinoCabo Verde, SandraFerreira, Isabel C.F.R.2018-01-25T10:00:00Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/15306engPereira, Eliana; Pimenta, Andreia I.; Calhelha, Ricardo C.; Antonio, Amilcar L.; Barros, Lillian; Santos-Buelga, Celestino; Verde, Sandra Cabo; Ferreira, Isabel C.F.R. (2017). Infusions of gamma irradiated Aloysia citrodora L. and Mentha x piperita L.: effects on phenolic composition, cytotoxicity, antibacterial and virucidal activities. Industrial Crops and Products. ISSN 0926-6690. 97, p. 582-5900926-669010.1016/j.indcrop.2017.01.007info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:35:48Zoai:bibliotecadigital.ipb.pt:10198/15306Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:04:55.875899Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Infusions of gamma irradiated Aloysia citrodora L. and Mentha x piperita L.: Effects on phenolic composition, cytotoxicity, antibacterial and virucidal activities
title Infusions of gamma irradiated Aloysia citrodora L. and Mentha x piperita L.: Effects on phenolic composition, cytotoxicity, antibacterial and virucidal activities
spellingShingle Infusions of gamma irradiated Aloysia citrodora L. and Mentha x piperita L.: Effects on phenolic composition, cytotoxicity, antibacterial and virucidal activities
Pereira, Eliana
Antibacterial activity
Aromatic herbs
Cytotoxicity
Gamma-radiation
Phenolic compounds
Virucidal activity
title_short Infusions of gamma irradiated Aloysia citrodora L. and Mentha x piperita L.: Effects on phenolic composition, cytotoxicity, antibacterial and virucidal activities
title_full Infusions of gamma irradiated Aloysia citrodora L. and Mentha x piperita L.: Effects on phenolic composition, cytotoxicity, antibacterial and virucidal activities
title_fullStr Infusions of gamma irradiated Aloysia citrodora L. and Mentha x piperita L.: Effects on phenolic composition, cytotoxicity, antibacterial and virucidal activities
title_full_unstemmed Infusions of gamma irradiated Aloysia citrodora L. and Mentha x piperita L.: Effects on phenolic composition, cytotoxicity, antibacterial and virucidal activities
title_sort Infusions of gamma irradiated Aloysia citrodora L. and Mentha x piperita L.: Effects on phenolic composition, cytotoxicity, antibacterial and virucidal activities
author Pereira, Eliana
author_facet Pereira, Eliana
Pimenta, Andreia I.
Calhelha, Ricardo C.
Antonio, Amilcar L.
Barros, Lillian
Santos-Buelga, Celestino
Cabo Verde, Sandra
Ferreira, Isabel C.F.R.
author_role author
author2 Pimenta, Andreia I.
Calhelha, Ricardo C.
Antonio, Amilcar L.
Barros, Lillian
Santos-Buelga, Celestino
Cabo Verde, Sandra
Ferreira, Isabel C.F.R.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Biblioteca Digital do IPB
dc.contributor.author.fl_str_mv Pereira, Eliana
Pimenta, Andreia I.
Calhelha, Ricardo C.
Antonio, Amilcar L.
Barros, Lillian
Santos-Buelga, Celestino
Cabo Verde, Sandra
Ferreira, Isabel C.F.R.
dc.subject.por.fl_str_mv Antibacterial activity
Aromatic herbs
Cytotoxicity
Gamma-radiation
Phenolic compounds
Virucidal activity
topic Antibacterial activity
Aromatic herbs
Cytotoxicity
Gamma-radiation
Phenolic compounds
Virucidal activity
description The incorporation of plants in industry requires high standards of hygiene, being the raw materials obligatorily decontaminated. Irradiation is increasingly applied as a decontamination technique in several countries. This work aimed to evaluate the effects of gamma radiation on the phenolic composition, cytotoxicity, virucidal and antimicrobial properties of Aloysia citrodora L. (lemon verbena) and Mentha x piperita L. (peppermint) infusions. Phenolic compounds profile was obtained by HPLC-DAD-ESI/MS and cytotoxicity was ev aluated in human tumour and non-tumour cell lines; in virucidal efficacy, MNV-1 and HAdV-5 viral titers were determined by plaque assay in Raw264.7 and A549 cell lines, respectively; and the antibacterial potential was evaluated against Gram-negative and Gram-positive bacteria. Radiation treatment caused a significant increase in total phenolic compounds of both plants, while the virucidal efficacy was depend on the plant, the virus, and absorbed dose. S. aureus, with MIC and MBC values of 5 mg/mL, was the only bacteria sensible to the infusions of non-irradiated and 1 kGy irradiated lemon verbena and peppermint samples; gamma radiation appears to cause no alteration in the antibacterial potential of the studied plants. Peppermint infusion (irradiated at 10 kGy) showed the highest cytotoxic potential in all tumour cell lines.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
2018-01-25T10:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10198/15306
url http://hdl.handle.net/10198/15306
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pereira, Eliana; Pimenta, Andreia I.; Calhelha, Ricardo C.; Antonio, Amilcar L.; Barros, Lillian; Santos-Buelga, Celestino; Verde, Sandra Cabo; Ferreira, Isabel C.F.R. (2017). Infusions of gamma irradiated Aloysia citrodora L. and Mentha x piperita L.: effects on phenolic composition, cytotoxicity, antibacterial and virucidal activities. Industrial Crops and Products. ISSN 0926-6690. 97, p. 582-590
0926-6690
10.1016/j.indcrop.2017.01.007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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