Etanercept-Induced Interstitial Lung Disease in a Patient with Plaque Psoriasis
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.29021/spdv.77.3.1098 |
Resumo: | Etanercept is one of the biologic drugs approved for the treatment of psoriasis. Despite its wide use and proven efficacy, few cases of pulmonary toxicity have been reported.We present a patient with psoriasis vulgaris medicated with etanercept. Seven months after its start, the patient developed productive cough, with no fever or constitutional symptoms. The thoracic computerized tomography revealed a pattern of bilateral dense micronodules, with predominance in the superior lobes. After suspension of etanercept, there was symptomatic and imaging resolution, without the need for additional pharmacological treatment. We switched the biologic agent for ustekinumab, with goodtolerance and high efficacy. |
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Etanercept-Induced Interstitial Lung Disease in a Patient with Plaque PsoriasisDoença Pulmonar Intersticial Induzida por Etanercept em Doente com Psoríase em PlacasEtanercept/adverse effectsLung DiseasesInterstitial/chemically inducedPsoriasis/drug therapyPsoríasereações adversas a fármacosdoença pulmonar intersticialetanerceptEtanercept is one of the biologic drugs approved for the treatment of psoriasis. Despite its wide use and proven efficacy, few cases of pulmonary toxicity have been reported.We present a patient with psoriasis vulgaris medicated with etanercept. Seven months after its start, the patient developed productive cough, with no fever or constitutional symptoms. The thoracic computerized tomography revealed a pattern of bilateral dense micronodules, with predominance in the superior lobes. After suspension of etanercept, there was symptomatic and imaging resolution, without the need for additional pharmacological treatment. We switched the biologic agent for ustekinumab, with goodtolerance and high efficacy.O etanercept é um dos fármacos biológicos aprovados para o tratamento da psoríase. Apesar da sua vasta utilização e comprovada eficácia, estão descritos raros casos de toxicidade pulmonar com a sua utilização.Apresentamos uma doente com psoríase vulgar medicada com etanercept. Sete meses após o início do fármaco, inicia um quadro de tosse produtiva, sem febre ou sintomas constitucionais. Na tomografia computorizada torácica, apresentava um padrão de micronódulos densos bilaterais, com predomínio nos lobos superiores. Após suspensão do agente verificou-se resolução sintomática e imagiológica, sem necessidade de tratamento farmacológico adicional. Optou-se pela troca de agente biológicopara ustecinumab, com boa tolerância e elevada eficácia.Sociedade Portuguesa de Dermatologia e Venereologia2019-10-11T00:00:00Zjournal articleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.29021/spdv.77.3.1098oai:ojs.revista.spdv.com.pt:article/1098Journal of the Portuguese Society of Dermatology and Venereology; Vol 77 No 3 (2019): July / September; 245-248Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 77 n. 3 (2019): Julho / Setembro; 245-2482182-24092182-2395reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://revista.spdv.com.pt/index.php/spdv/article/view/1098https://doi.org/10.29021/spdv.77.3.1098https://revista.spdv.com.pt/index.php/spdv/article/view/1098/792Lopes, JorgeCampainha, SérgioSousa, CristinaTeixeira, DiogoBaptista, ArmandoMoreira, Anainfo:eu-repo/semantics/openAccess2022-10-06T12:35:12Zoai:ojs.revista.spdv.com.pt:article/1098Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:10.494666Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Etanercept-Induced Interstitial Lung Disease in a Patient with Plaque Psoriasis Doença Pulmonar Intersticial Induzida por Etanercept em Doente com Psoríase em Placas |
title |
Etanercept-Induced Interstitial Lung Disease in a Patient with Plaque Psoriasis |
spellingShingle |
Etanercept-Induced Interstitial Lung Disease in a Patient with Plaque Psoriasis Lopes, Jorge Etanercept/adverse effects Lung Diseases Interstitial/chemically induced Psoriasis/drug therapy Psoríase reações adversas a fármacos doença pulmonar intersticial etanercept |
title_short |
Etanercept-Induced Interstitial Lung Disease in a Patient with Plaque Psoriasis |
title_full |
Etanercept-Induced Interstitial Lung Disease in a Patient with Plaque Psoriasis |
title_fullStr |
Etanercept-Induced Interstitial Lung Disease in a Patient with Plaque Psoriasis |
title_full_unstemmed |
Etanercept-Induced Interstitial Lung Disease in a Patient with Plaque Psoriasis |
title_sort |
Etanercept-Induced Interstitial Lung Disease in a Patient with Plaque Psoriasis |
author |
Lopes, Jorge |
author_facet |
Lopes, Jorge Campainha, Sérgio Sousa, Cristina Teixeira, Diogo Baptista, Armando Moreira, Ana |
author_role |
author |
author2 |
Campainha, Sérgio Sousa, Cristina Teixeira, Diogo Baptista, Armando Moreira, Ana |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Lopes, Jorge Campainha, Sérgio Sousa, Cristina Teixeira, Diogo Baptista, Armando Moreira, Ana |
dc.subject.por.fl_str_mv |
Etanercept/adverse effects Lung Diseases Interstitial/chemically induced Psoriasis/drug therapy Psoríase reações adversas a fármacos doença pulmonar intersticial etanercept |
topic |
Etanercept/adverse effects Lung Diseases Interstitial/chemically induced Psoriasis/drug therapy Psoríase reações adversas a fármacos doença pulmonar intersticial etanercept |
description |
Etanercept is one of the biologic drugs approved for the treatment of psoriasis. Despite its wide use and proven efficacy, few cases of pulmonary toxicity have been reported.We present a patient with psoriasis vulgaris medicated with etanercept. Seven months after its start, the patient developed productive cough, with no fever or constitutional symptoms. The thoracic computerized tomography revealed a pattern of bilateral dense micronodules, with predominance in the superior lobes. After suspension of etanercept, there was symptomatic and imaging resolution, without the need for additional pharmacological treatment. We switched the biologic agent for ustekinumab, with goodtolerance and high efficacy. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-11T00:00:00Z |
dc.type.driver.fl_str_mv |
journal article info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.29021/spdv.77.3.1098 oai:ojs.revista.spdv.com.pt:article/1098 |
url |
https://doi.org/10.29021/spdv.77.3.1098 |
identifier_str_mv |
oai:ojs.revista.spdv.com.pt:article/1098 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://revista.spdv.com.pt/index.php/spdv/article/view/1098 https://doi.org/10.29021/spdv.77.3.1098 https://revista.spdv.com.pt/index.php/spdv/article/view/1098/792 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Dermatologia e Venereologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Dermatologia e Venereologia |
dc.source.none.fl_str_mv |
Journal of the Portuguese Society of Dermatology and Venereology; Vol 77 No 3 (2019): July / September; 245-248 Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 77 n. 3 (2019): Julho / Setembro; 245-248 2182-2409 2182-2395 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799130567562756096 |