Zinc therapy of neurological Wilson’s disease in a woman with two foetus with agenesis of the corpus callosum

Detalhes bibliográficos
Autor(a) principal: Murinello,António
Data de Publicação: 2010
Outros Autores: Tomé,Teresa, Goulão,Augusto, Cohen,Álvaro
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-81782010000300005
Resumo: CLINICAL REPORT: A patient diagnosed Wilson’s disease (WD) 22 years previously, successfully tre­ated initially with zinc, developed neuropsychiatric disease after years of irregular therapy. Reassuming zinc therapy was successful. After a normal pregnancy, she had two therapeutic abortions for corpus callosum agenesis, and a missed abortion. We review the genetics, physiopathology, clinics and imagiologic response to zinc therapy, the problems of pregnancy in WD, advising to maintain therapy. A hypothetic cause for fetus brain anomaly would be hypocupremia due to zinc therapy, confronting with two other possibilities, one related to Wilson’s disease in itself, other due to a congenital syndrome of agenesis of the corpus callosum, impossible to diagnose by our available diagnostic methods.
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spelling Zinc therapy of neurological Wilson’s disease in a woman with two foetus with agenesis of the corpus callosumWilson’s diseasezinccorpus callosum agenesishypocupremiaCLINICAL REPORT: A patient diagnosed Wilson’s disease (WD) 22 years previously, successfully tre­ated initially with zinc, developed neuropsychiatric disease after years of irregular therapy. Reassuming zinc therapy was successful. After a normal pregnancy, she had two therapeutic abortions for corpus callosum agenesis, and a missed abortion. We review the genetics, physiopathology, clinics and imagiologic response to zinc therapy, the problems of pregnancy in WD, advising to maintain therapy. A hypothetic cause for fetus brain anomaly would be hypocupremia due to zinc therapy, confronting with two other possibilities, one related to Wilson’s disease in itself, other due to a congenital syndrome of agenesis of the corpus callosum, impossible to diagnose by our available diagnostic methods.Sociedade Portuguesa de Gastrenterologia2010-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/reporttext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-81782010000300005Jornal Português de Gastrenterologia v.17 n.3 2010reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-81782010000300005Murinello,AntónioTomé,TeresaGoulão,AugustoCohen,Álvaroinfo:eu-repo/semantics/openAccess2024-02-06T17:08:59Zoai:scielo:S0872-81782010000300005Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:21:08.572908Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Zinc therapy of neurological Wilson’s disease in a woman with two foetus with agenesis of the corpus callosum
title Zinc therapy of neurological Wilson’s disease in a woman with two foetus with agenesis of the corpus callosum
spellingShingle Zinc therapy of neurological Wilson’s disease in a woman with two foetus with agenesis of the corpus callosum
Murinello,António
Wilson’s disease
zinc
corpus callosum agenesis
hypocupremia
title_short Zinc therapy of neurological Wilson’s disease in a woman with two foetus with agenesis of the corpus callosum
title_full Zinc therapy of neurological Wilson’s disease in a woman with two foetus with agenesis of the corpus callosum
title_fullStr Zinc therapy of neurological Wilson’s disease in a woman with two foetus with agenesis of the corpus callosum
title_full_unstemmed Zinc therapy of neurological Wilson’s disease in a woman with two foetus with agenesis of the corpus callosum
title_sort Zinc therapy of neurological Wilson’s disease in a woman with two foetus with agenesis of the corpus callosum
author Murinello,António
author_facet Murinello,António
Tomé,Teresa
Goulão,Augusto
Cohen,Álvaro
author_role author
author2 Tomé,Teresa
Goulão,Augusto
Cohen,Álvaro
author2_role author
author
author
dc.contributor.author.fl_str_mv Murinello,António
Tomé,Teresa
Goulão,Augusto
Cohen,Álvaro
dc.subject.por.fl_str_mv Wilson’s disease
zinc
corpus callosum agenesis
hypocupremia
topic Wilson’s disease
zinc
corpus callosum agenesis
hypocupremia
description CLINICAL REPORT: A patient diagnosed Wilson’s disease (WD) 22 years previously, successfully tre­ated initially with zinc, developed neuropsychiatric disease after years of irregular therapy. Reassuming zinc therapy was successful. After a normal pregnancy, she had two therapeutic abortions for corpus callosum agenesis, and a missed abortion. We review the genetics, physiopathology, clinics and imagiologic response to zinc therapy, the problems of pregnancy in WD, advising to maintain therapy. A hypothetic cause for fetus brain anomaly would be hypocupremia due to zinc therapy, confronting with two other possibilities, one related to Wilson’s disease in itself, other due to a congenital syndrome of agenesis of the corpus callosum, impossible to diagnose by our available diagnostic methods.
publishDate 2010
dc.date.none.fl_str_mv 2010-05-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-81782010000300005
url http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-81782010000300005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-81782010000300005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Gastrenterologia
publisher.none.fl_str_mv Sociedade Portuguesa de Gastrenterologia
dc.source.none.fl_str_mv Jornal Português de Gastrenterologia v.17 n.3 2010
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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