Analysis of the Cochrane Review: Topical Treatments for Scalp Psoriasis. Cochrane Database Syst Rev. 2016;2:CD009687.

Detalhes bibliográficos
Autor(a) principal: Queirós, Catarina Soares
Data de Publicação: 2017
Outros Autores: Duarte, Gonçalo Silva, Costa, João, Vaz-Carneiro, António
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8910
Resumo: Regardless the psoriasis subtype, up to 79% of people with this skin condition present scalp involvement, which is often the first site to show symptoms of the disease. In addition to being itchy, the red and scaly lesions are usually easy to see, and may be embarrassing. Topical therapy is usually the first line of treatment; however the wide array of available interventions can make the choice difficult, and may even lead to an inadequate treatment. The objective of this review was to evaluate the efficacy and safety of topical treatments for scalp psoriasis. A systematic review was performed according to the methodology recommended by Cochrane in order to evaluate the clinical severity of psoriasis, quality of life, and adverse events that led to treatment discontinuation. To evaluate this, 59 studies were included, with a total of 11 561 participants, and 15 comparisons were made between the various drugs and application vehicles tested. The principal conclusion is that corticosteroids of high or very high potency are more effective than vitamin D. The combination of a corticosteroid with vitamin D has only a marginal benefit over corticosteroid monotherapy, but is superior to vitamin D alone. Given the similar safety profile and only marginal benefit of the combination of corticosteroid with vitamin D over the corticosteroid alone, topical corticosteroid monotherapy appears to be fully acceptable for short-term therapy of scalp psoriasis.
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spelling Analysis of the Cochrane Review: Topical Treatments for Scalp Psoriasis. Cochrane Database Syst Rev. 2016;2:CD009687.Análise da Revisão Cochrane: Tratamentos Tópicos para a Psoríase do Couro-Cabeludo. Cochrane Database Syst Rev. 2016;2:CD009687.AdministrationTopicalDermatologic Agents/therapeutic usePsoriasis/therapyScalp Dermatoses/therapySteroidsSystematic ReviewVitamin DAdministração TópicaDermatoses do Couro Cabeludo/tratamentoEsteroidesFármacos Dermatológicos/uso terapêuticoPsoriase/tratamentoRevisão SistemáticaVitamina DRegardless the psoriasis subtype, up to 79% of people with this skin condition present scalp involvement, which is often the first site to show symptoms of the disease. In addition to being itchy, the red and scaly lesions are usually easy to see, and may be embarrassing. Topical therapy is usually the first line of treatment; however the wide array of available interventions can make the choice difficult, and may even lead to an inadequate treatment. The objective of this review was to evaluate the efficacy and safety of topical treatments for scalp psoriasis. A systematic review was performed according to the methodology recommended by Cochrane in order to evaluate the clinical severity of psoriasis, quality of life, and adverse events that led to treatment discontinuation. To evaluate this, 59 studies were included, with a total of 11 561 participants, and 15 comparisons were made between the various drugs and application vehicles tested. The principal conclusion is that corticosteroids of high or very high potency are more effective than vitamin D. The combination of a corticosteroid with vitamin D has only a marginal benefit over corticosteroid monotherapy, but is superior to vitamin D alone. Given the similar safety profile and only marginal benefit of the combination of corticosteroid with vitamin D over the corticosteroid alone, topical corticosteroid monotherapy appears to be fully acceptable for short-term therapy of scalp psoriasis.Independentemente do tipo de psoríase, até 79% dos doentes com esta patologia apresentam atingimento do couro cabeludo, sendo este frequentemente o primeiro local a mostrar sintomas da doença. Para além do prurido, as lesões avermelhadas e escamosas são visíveis e muitas vezes embaraçosas. A terapêutica tópica é geralmente a primeira opção para estes doentes, no entanto a ampla gama de tratamentos disponíveis pode muitas vezes dificultar a escolha e levar a um tratamento potencialmente desadequado. O objetivo desta revisão foi avaliar a eficácia e a segurança dos tratamentos tópicos para a psoríase do couro cabeludo. Foi efetuada uma revisão sistemática de acordo com a metodologia preconizada pela Cochrane, com vista à avaliação da redução da gravidade clínica da psoríase, melhoria da qualidade de vida e efeitos adversos que motivassem a suspensão do tratamento. Para tal, foram incluídos 59 estudos, com um total de 11 561 participantes, tendo sido efetuadas 15 comparações entre os vários fármacos e veículos de aplicação testados. Os resultados obtidos sugerem que os corticosteroides de potência elevada ou muito elevada são mais eficazes que a vitamina D. A combinação de um corticosteroide com a vitamina D tem apenas um benefício marginal em relação à monoterapia com corticosteroide, mas é superior à vitamina D isolada. Dado o perfil de segurança semelhante e o benefício apenas marginal da combinação corticosteroide com vitamina D sobre o corticosteroide isolado, a monoterapia com corticosteroide tópico parece ser aceitável para a terapia a curto prazo da psoríase do couro cabeludo.Ordem dos Médicos2017-03-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8910oai:ojs.www.actamedicaportuguesa.com:article/8910Acta Médica Portuguesa; Vol. 30 No. 3 (2017): March; 163-168Acta Médica Portuguesa; Vol. 30 N.º 3 (2017): Março; 163-1681646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8910https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8910/4964Direitos de Autor (c) 2017 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessQueirós, Catarina SoaresDuarte, Gonçalo SilvaCosta, JoãoVaz-Carneiro, António2022-12-20T11:05:39Zoai:ojs.www.actamedicaportuguesa.com:article/8910Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:19:39.443160Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Analysis of the Cochrane Review: Topical Treatments for Scalp Psoriasis. Cochrane Database Syst Rev. 2016;2:CD009687.
Análise da Revisão Cochrane: Tratamentos Tópicos para a Psoríase do Couro-Cabeludo. Cochrane Database Syst Rev. 2016;2:CD009687.
title Analysis of the Cochrane Review: Topical Treatments for Scalp Psoriasis. Cochrane Database Syst Rev. 2016;2:CD009687.
spellingShingle Analysis of the Cochrane Review: Topical Treatments for Scalp Psoriasis. Cochrane Database Syst Rev. 2016;2:CD009687.
Queirós, Catarina Soares
Administration
Topical
Dermatologic Agents/therapeutic use
Psoriasis/therapy
Scalp Dermatoses/therapy
Steroids
Systematic Review
Vitamin D
Administração Tópica
Dermatoses do Couro Cabeludo/tratamento
Esteroides
Fármacos Dermatológicos/uso terapêutico
Psoriase/tratamento
Revisão Sistemática
Vitamina D
title_short Analysis of the Cochrane Review: Topical Treatments for Scalp Psoriasis. Cochrane Database Syst Rev. 2016;2:CD009687.
title_full Analysis of the Cochrane Review: Topical Treatments for Scalp Psoriasis. Cochrane Database Syst Rev. 2016;2:CD009687.
title_fullStr Analysis of the Cochrane Review: Topical Treatments for Scalp Psoriasis. Cochrane Database Syst Rev. 2016;2:CD009687.
title_full_unstemmed Analysis of the Cochrane Review: Topical Treatments for Scalp Psoriasis. Cochrane Database Syst Rev. 2016;2:CD009687.
title_sort Analysis of the Cochrane Review: Topical Treatments for Scalp Psoriasis. Cochrane Database Syst Rev. 2016;2:CD009687.
author Queirós, Catarina Soares
author_facet Queirós, Catarina Soares
Duarte, Gonçalo Silva
Costa, João
Vaz-Carneiro, António
author_role author
author2 Duarte, Gonçalo Silva
Costa, João
Vaz-Carneiro, António
author2_role author
author
author
dc.contributor.author.fl_str_mv Queirós, Catarina Soares
Duarte, Gonçalo Silva
Costa, João
Vaz-Carneiro, António
dc.subject.por.fl_str_mv Administration
Topical
Dermatologic Agents/therapeutic use
Psoriasis/therapy
Scalp Dermatoses/therapy
Steroids
Systematic Review
Vitamin D
Administração Tópica
Dermatoses do Couro Cabeludo/tratamento
Esteroides
Fármacos Dermatológicos/uso terapêutico
Psoriase/tratamento
Revisão Sistemática
Vitamina D
topic Administration
Topical
Dermatologic Agents/therapeutic use
Psoriasis/therapy
Scalp Dermatoses/therapy
Steroids
Systematic Review
Vitamin D
Administração Tópica
Dermatoses do Couro Cabeludo/tratamento
Esteroides
Fármacos Dermatológicos/uso terapêutico
Psoriase/tratamento
Revisão Sistemática
Vitamina D
description Regardless the psoriasis subtype, up to 79% of people with this skin condition present scalp involvement, which is often the first site to show symptoms of the disease. In addition to being itchy, the red and scaly lesions are usually easy to see, and may be embarrassing. Topical therapy is usually the first line of treatment; however the wide array of available interventions can make the choice difficult, and may even lead to an inadequate treatment. The objective of this review was to evaluate the efficacy and safety of topical treatments for scalp psoriasis. A systematic review was performed according to the methodology recommended by Cochrane in order to evaluate the clinical severity of psoriasis, quality of life, and adverse events that led to treatment discontinuation. To evaluate this, 59 studies were included, with a total of 11 561 participants, and 15 comparisons were made between the various drugs and application vehicles tested. The principal conclusion is that corticosteroids of high or very high potency are more effective than vitamin D. The combination of a corticosteroid with vitamin D has only a marginal benefit over corticosteroid monotherapy, but is superior to vitamin D alone. Given the similar safety profile and only marginal benefit of the combination of corticosteroid with vitamin D over the corticosteroid alone, topical corticosteroid monotherapy appears to be fully acceptable for short-term therapy of scalp psoriasis.
publishDate 2017
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8910/4964
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publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 30 No. 3 (2017): March; 163-168
Acta Médica Portuguesa; Vol. 30 N.º 3 (2017): Março; 163-168
1646-0758
0870-399X
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