The roles of juvenile hormone, insulin/target of rapamycin, and ecydsone signaling in regulating body size inDrosophila

Detalhes bibliográficos
Autor(a) principal: Mirth, Christen Kerry
Data de Publicação: 2014
Outros Autores: Shingleton, Alexander William
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/387
Resumo: Understanding how organisms regulate their body size has interested biologists for decades. Recent work has shown that both insulin/target of rapamycin (TOR) signaling and the steroid hormone ecdysone act to regulate rates of growth and the duration of the growth period in the fruit fly, Drosophila melanogaster. Our recent work has uncovered a third level of interaction, whereby juvenile hormone (JH) regulates levels of both ecdysone and insulin/TOR signaling to control growth rates. These studies highlight a complex network of interactions involved in regulating body and organ size.
id RCAP_8d37cdbf1643e8256d07139e21914d4e
oai_identifier_str oai:arca.igc.gulbenkian.pt:10400.7/387
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling The roles of juvenile hormone, insulin/target of rapamycin, and ecydsone signaling in regulating body size inDrosophilabody sizegrowth rategrowth durationjuvenile hormoneecdysoneinsulin/insulin-like growth factor signallingUnderstanding how organisms regulate their body size has interested biologists for decades. Recent work has shown that both insulin/target of rapamycin (TOR) signaling and the steroid hormone ecdysone act to regulate rates of growth and the duration of the growth period in the fruit fly, Drosophila melanogaster. Our recent work has uncovered a third level of interaction, whereby juvenile hormone (JH) regulates levels of both ecdysone and insulin/TOR signaling to control growth rates. These studies highlight a complex network of interactions involved in regulating body and organ size.Sem patrocinadoresTaylor & Francis GroupARCAMirth, Christen KerryShingleton, Alexander William2015-10-08T11:47:52Z2014-10-312014-10-31T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/387engChristen Kerry Mirth & Alexander William Shingleton (2014) The roles of juvenile hormone, insulin/target of rapamycin, and ecydsone signaling in regulating body size in Drosophila, Communicative & Integrative Biology, 7:5, 1-3, DOI: 10.4161/cib.2924010.4161/cib.29240info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:34:47Zoai:arca.igc.gulbenkian.pt:10400.7/387Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:41.230616Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The roles of juvenile hormone, insulin/target of rapamycin, and ecydsone signaling in regulating body size inDrosophila
title The roles of juvenile hormone, insulin/target of rapamycin, and ecydsone signaling in regulating body size inDrosophila
spellingShingle The roles of juvenile hormone, insulin/target of rapamycin, and ecydsone signaling in regulating body size inDrosophila
Mirth, Christen Kerry
body size
growth rate
growth duration
juvenile hormone
ecdysone
insulin/insulin-like growth factor signalling
title_short The roles of juvenile hormone, insulin/target of rapamycin, and ecydsone signaling in regulating body size inDrosophila
title_full The roles of juvenile hormone, insulin/target of rapamycin, and ecydsone signaling in regulating body size inDrosophila
title_fullStr The roles of juvenile hormone, insulin/target of rapamycin, and ecydsone signaling in regulating body size inDrosophila
title_full_unstemmed The roles of juvenile hormone, insulin/target of rapamycin, and ecydsone signaling in regulating body size inDrosophila
title_sort The roles of juvenile hormone, insulin/target of rapamycin, and ecydsone signaling in regulating body size inDrosophila
author Mirth, Christen Kerry
author_facet Mirth, Christen Kerry
Shingleton, Alexander William
author_role author
author2 Shingleton, Alexander William
author2_role author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Mirth, Christen Kerry
Shingleton, Alexander William
dc.subject.por.fl_str_mv body size
growth rate
growth duration
juvenile hormone
ecdysone
insulin/insulin-like growth factor signalling
topic body size
growth rate
growth duration
juvenile hormone
ecdysone
insulin/insulin-like growth factor signalling
description Understanding how organisms regulate their body size has interested biologists for decades. Recent work has shown that both insulin/target of rapamycin (TOR) signaling and the steroid hormone ecdysone act to regulate rates of growth and the duration of the growth period in the fruit fly, Drosophila melanogaster. Our recent work has uncovered a third level of interaction, whereby juvenile hormone (JH) regulates levels of both ecdysone and insulin/TOR signaling to control growth rates. These studies highlight a complex network of interactions involved in regulating body and organ size.
publishDate 2014
dc.date.none.fl_str_mv 2014-10-31
2014-10-31T00:00:00Z
2015-10-08T11:47:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/387
url http://hdl.handle.net/10400.7/387
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Christen Kerry Mirth & Alexander William Shingleton (2014) The roles of juvenile hormone, insulin/target of rapamycin, and ecydsone signaling in regulating body size in Drosophila, Communicative & Integrative Biology, 7:5, 1-3, DOI: 10.4161/cib.29240
10.4161/cib.29240
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis Group
publisher.none.fl_str_mv Taylor & Francis Group
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799130572218433536

Registros relacionados