Beyond penicillin: the potential of filamentous fungi for drug discovery in the age of antibiotic resistance
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/86074 |
Resumo: | Antibiotics are a staple in current medicine for the therapy of infectious diseases. However, their extensive use and misuse, combined with the high adaptability of bacteria, has dangerously increased the incidence of multi-drug-resistant (MDR) bacteria. This makes the treatment of infections challenging, especially when MDR bacteria form biofilms. The most recent antibiotics entering the market have very similar modes of action to the existing ones, so bacteria rapidly catch up to those as well. As such, it is very important to adopt effective measures to avoid the development of antibiotic resistance by pathogenic bacteria, but also to perform bioprospecting of new molecules from diverse sources to expand the arsenal of drugs that are available to fight these infectious bacteria. Filamentous fungi have a large and vastly unexplored secondary metabolome and are rich in bioactive molecules that can be potential novel antimicrobial drugs. Their production can be challenging, as the associated biosynthetic pathways may not be active under standard culture conditions. New techniques involving metabolic and genetic engineering can help boost antibiotic production. This study aims to review the bioprospection of fungi to produce new drugs to face the growing problem of MDR bacteria and biofilm-associated infections. |
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Beyond penicillin: the potential of filamentous fungi for drug discovery in the age of antibiotic resistanceantibiotic resistancebiofilm controlantibiotic bioprospectionbioprocessfilamentous fungiAntibiotics are a staple in current medicine for the therapy of infectious diseases. However, their extensive use and misuse, combined with the high adaptability of bacteria, has dangerously increased the incidence of multi-drug-resistant (MDR) bacteria. This makes the treatment of infections challenging, especially when MDR bacteria form biofilms. The most recent antibiotics entering the market have very similar modes of action to the existing ones, so bacteria rapidly catch up to those as well. As such, it is very important to adopt effective measures to avoid the development of antibiotic resistance by pathogenic bacteria, but also to perform bioprospecting of new molecules from diverse sources to expand the arsenal of drugs that are available to fight these infectious bacteria. Filamentous fungi have a large and vastly unexplored secondary metabolome and are rich in bioactive molecules that can be potential novel antimicrobial drugs. Their production can be challenging, as the associated biosynthetic pathways may not be active under standard culture conditions. New techniques involving metabolic and genetic engineering can help boost antibiotic production. This study aims to review the bioprospection of fungi to produce new drugs to face the growing problem of MDR bacteria and biofilm-associated infections.This research was funded by LA/P/0045/2020 (ALiCE), UIDB/00511/2020, and UIDP/00511/2020 (LEPABE); funded by national funds through FCT/MCTES (PIDDAC), UIDB/04469/2020 (CEB), and LABBELS—Associate Laboratory in Biotechnology, Bioengineering and Microelectromechanical Systems, LA/P/0029/2020; Germirrad-POCI-01-0247-FEDER-072237 funded by FEDER funds through COMPETE2020—Programa Operacional Competitividade e Internacionalização (POCI) and by national funds (PIDDAC) through FCT/MCTES; and the FCT grant (2020.04773.BD).info:eu-repo/semantics/publishedVersionMDPIUniversidade do MinhoCorreia, JoãoBorges, AnabelaSimões, M.Simões, Lúcia Chaves2023-07-292023-07-29T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/86074engCorreia, J.; Borges, A.; Simões, M.; Simões, L.C. Beyond Penicillin: The Potential of Filamentous Fungi for Drug Discovery in the Age of Antibiotic Resistance. Antibiotics 2023, 12, 1250. https://doi.org/10.3390/antibiotics120812502079-638210.3390/antibiotics12081250https://www.mdpi.com/2079-6382/12/8/1250info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-12T01:18:28Zoai:repositorium.sdum.uminho.pt:1822/86074Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:26:42.014930Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Beyond penicillin: the potential of filamentous fungi for drug discovery in the age of antibiotic resistance |
title |
Beyond penicillin: the potential of filamentous fungi for drug discovery in the age of antibiotic resistance |
spellingShingle |
Beyond penicillin: the potential of filamentous fungi for drug discovery in the age of antibiotic resistance Correia, João antibiotic resistance biofilm control antibiotic bioprospection bioprocess filamentous fungi |
title_short |
Beyond penicillin: the potential of filamentous fungi for drug discovery in the age of antibiotic resistance |
title_full |
Beyond penicillin: the potential of filamentous fungi for drug discovery in the age of antibiotic resistance |
title_fullStr |
Beyond penicillin: the potential of filamentous fungi for drug discovery in the age of antibiotic resistance |
title_full_unstemmed |
Beyond penicillin: the potential of filamentous fungi for drug discovery in the age of antibiotic resistance |
title_sort |
Beyond penicillin: the potential of filamentous fungi for drug discovery in the age of antibiotic resistance |
author |
Correia, João |
author_facet |
Correia, João Borges, Anabela Simões, M. Simões, Lúcia Chaves |
author_role |
author |
author2 |
Borges, Anabela Simões, M. Simões, Lúcia Chaves |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Correia, João Borges, Anabela Simões, M. Simões, Lúcia Chaves |
dc.subject.por.fl_str_mv |
antibiotic resistance biofilm control antibiotic bioprospection bioprocess filamentous fungi |
topic |
antibiotic resistance biofilm control antibiotic bioprospection bioprocess filamentous fungi |
description |
Antibiotics are a staple in current medicine for the therapy of infectious diseases. However, their extensive use and misuse, combined with the high adaptability of bacteria, has dangerously increased the incidence of multi-drug-resistant (MDR) bacteria. This makes the treatment of infections challenging, especially when MDR bacteria form biofilms. The most recent antibiotics entering the market have very similar modes of action to the existing ones, so bacteria rapidly catch up to those as well. As such, it is very important to adopt effective measures to avoid the development of antibiotic resistance by pathogenic bacteria, but also to perform bioprospecting of new molecules from diverse sources to expand the arsenal of drugs that are available to fight these infectious bacteria. Filamentous fungi have a large and vastly unexplored secondary metabolome and are rich in bioactive molecules that can be potential novel antimicrobial drugs. Their production can be challenging, as the associated biosynthetic pathways may not be active under standard culture conditions. New techniques involving metabolic and genetic engineering can help boost antibiotic production. This study aims to review the bioprospection of fungi to produce new drugs to face the growing problem of MDR bacteria and biofilm-associated infections. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29 2023-07-29T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/86074 |
url |
https://hdl.handle.net/1822/86074 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Correia, J.; Borges, A.; Simões, M.; Simões, L.C. Beyond Penicillin: The Potential of Filamentous Fungi for Drug Discovery in the Age of Antibiotic Resistance. Antibiotics 2023, 12, 1250. https://doi.org/10.3390/antibiotics12081250 2079-6382 10.3390/antibiotics12081250 https://www.mdpi.com/2079-6382/12/8/1250 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133534274715648 |