Influence of Biochemical and Anthropometric Factors on the Presence of Insulin Resistance in Adolescents
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/42068 https://doi.org/10.1177/1099800416648207 |
Resumo: | Background: Insulin resistance plays a determinant role in the development of metabolic syndrome in adolescents. The objective of the present study was to determine the influence of factors commonly associated with insulin resistance in a sample of adolescents. Methods: This cross-sectional study included 976 adolescents from southeast Spain. Anthropometric and biochemical measurements were performed, and insulin resistance was assessed using the homeostasis model assessment–insulin resistance (HOMA-IR). Results: Subjects with abnormal HOMA-IR values had significantly higher body mass index (BMI), body fat content, waist circumference, and systolic blood pressure (BP) than those with normal values. Furthermore, levels of glucose, insulin, glycosylated hemoglobin, total cholesterol, triglycerides, low-density lipoprotein-cholesterol, homocysteine, nonesterified fatty acids, and ceruloplasmin were higher in subjects with abnormal HOMA-IR values. Multivariate logistic regression analysis showed the highest odds ratio (OR) for BMI and that combinations of BMI with body fat content or systolic BP can increase the risk of insulin resistance 7-fold. Discussion: Anthropometric indicators have different levels of influence on the risk of insulin resistance in adolescents, and a combination of two of these indicators is enough to increase the risk 7-fold. Since the highest OR was observed for BMI, the greatest effort should be directed to reducing this parameter in adolescents. An adequate understanding by nursing personnel of factors associated with insulin resistance is a key factor in the prevention of this pathophysiological condition and its complications in adolescents. |
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Influence of Biochemical and Anthropometric Factors on the Presence of Insulin Resistance in Adolescentsinsulin resistance,risk factors,metabolic syndrome,HOMA-IR,adolescenceBackground: Insulin resistance plays a determinant role in the development of metabolic syndrome in adolescents. The objective of the present study was to determine the influence of factors commonly associated with insulin resistance in a sample of adolescents. Methods: This cross-sectional study included 976 adolescents from southeast Spain. Anthropometric and biochemical measurements were performed, and insulin resistance was assessed using the homeostasis model assessment–insulin resistance (HOMA-IR). Results: Subjects with abnormal HOMA-IR values had significantly higher body mass index (BMI), body fat content, waist circumference, and systolic blood pressure (BP) than those with normal values. Furthermore, levels of glucose, insulin, glycosylated hemoglobin, total cholesterol, triglycerides, low-density lipoprotein-cholesterol, homocysteine, nonesterified fatty acids, and ceruloplasmin were higher in subjects with abnormal HOMA-IR values. Multivariate logistic regression analysis showed the highest odds ratio (OR) for BMI and that combinations of BMI with body fat content or systolic BP can increase the risk of insulin resistance 7-fold. Discussion: Anthropometric indicators have different levels of influence on the risk of insulin resistance in adolescents, and a combination of two of these indicators is enough to increase the risk 7-fold. Since the highest OR was observed for BMI, the greatest effort should be directed to reducing this parameter in adolescents. An adequate understanding by nursing personnel of factors associated with insulin resistance is a key factor in the prevention of this pathophysiological condition and its complications in adolescents.2016-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/42068http://hdl.handle.net/10316/42068https://doi.org/10.1177/1099800416648207https://doi.org/10.1177/1099800416648207enghttp://journals.sagepub.com/doi/abs/10.1177/1099800416648207González-Jiménez, EmilioSchmidt-RioValle, JacquelineMontero-Alonso, Miguel A.Padez, CristinaGarcía-García, Carmen J.Perona, Javier S.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-08-31T09:36:56Zoai:estudogeral.uc.pt:10316/42068Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:52:42.274568Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Influence of Biochemical and Anthropometric Factors on the Presence of Insulin Resistance in Adolescents |
title |
Influence of Biochemical and Anthropometric Factors on the Presence of Insulin Resistance in Adolescents |
spellingShingle |
Influence of Biochemical and Anthropometric Factors on the Presence of Insulin Resistance in Adolescents González-Jiménez, Emilio insulin resistance, risk factors, metabolic syndrome, HOMA-IR, adolescence |
title_short |
Influence of Biochemical and Anthropometric Factors on the Presence of Insulin Resistance in Adolescents |
title_full |
Influence of Biochemical and Anthropometric Factors on the Presence of Insulin Resistance in Adolescents |
title_fullStr |
Influence of Biochemical and Anthropometric Factors on the Presence of Insulin Resistance in Adolescents |
title_full_unstemmed |
Influence of Biochemical and Anthropometric Factors on the Presence of Insulin Resistance in Adolescents |
title_sort |
Influence of Biochemical and Anthropometric Factors on the Presence of Insulin Resistance in Adolescents |
author |
González-Jiménez, Emilio |
author_facet |
González-Jiménez, Emilio Schmidt-RioValle, Jacqueline Montero-Alonso, Miguel A. Padez, Cristina García-García, Carmen J. Perona, Javier S. |
author_role |
author |
author2 |
Schmidt-RioValle, Jacqueline Montero-Alonso, Miguel A. Padez, Cristina García-García, Carmen J. Perona, Javier S. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
González-Jiménez, Emilio Schmidt-RioValle, Jacqueline Montero-Alonso, Miguel A. Padez, Cristina García-García, Carmen J. Perona, Javier S. |
dc.subject.por.fl_str_mv |
insulin resistance, risk factors, metabolic syndrome, HOMA-IR, adolescence |
topic |
insulin resistance, risk factors, metabolic syndrome, HOMA-IR, adolescence |
description |
Background: Insulin resistance plays a determinant role in the development of metabolic syndrome in adolescents. The objective of the present study was to determine the influence of factors commonly associated with insulin resistance in a sample of adolescents. Methods: This cross-sectional study included 976 adolescents from southeast Spain. Anthropometric and biochemical measurements were performed, and insulin resistance was assessed using the homeostasis model assessment–insulin resistance (HOMA-IR). Results: Subjects with abnormal HOMA-IR values had significantly higher body mass index (BMI), body fat content, waist circumference, and systolic blood pressure (BP) than those with normal values. Furthermore, levels of glucose, insulin, glycosylated hemoglobin, total cholesterol, triglycerides, low-density lipoprotein-cholesterol, homocysteine, nonesterified fatty acids, and ceruloplasmin were higher in subjects with abnormal HOMA-IR values. Multivariate logistic regression analysis showed the highest odds ratio (OR) for BMI and that combinations of BMI with body fat content or systolic BP can increase the risk of insulin resistance 7-fold. Discussion: Anthropometric indicators have different levels of influence on the risk of insulin resistance in adolescents, and a combination of two of these indicators is enough to increase the risk 7-fold. Since the highest OR was observed for BMI, the greatest effort should be directed to reducing this parameter in adolescents. An adequate understanding by nursing personnel of factors associated with insulin resistance is a key factor in the prevention of this pathophysiological condition and its complications in adolescents. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-10 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/42068 http://hdl.handle.net/10316/42068 https://doi.org/10.1177/1099800416648207 https://doi.org/10.1177/1099800416648207 |
url |
http://hdl.handle.net/10316/42068 https://doi.org/10.1177/1099800416648207 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://journals.sagepub.com/doi/abs/10.1177/1099800416648207 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133815365435392 |