Chitosan scaffolds with mesoporous hydroxyapatite and mesoporous bioactive glass

Detalhes bibliográficos
Autor(a) principal: Pádua, Ana Sofia
Data de Publicação: 2023
Outros Autores: Figueiredo, Lígia, Silva, Jorge Carvalho, Borges, João Paulo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/154946
Resumo: Publisher Copyright: © 2023, The Author(s).
id RCAP_8da5a4f607ccc5fab91bf53638708b82
oai_identifier_str oai:run.unl.pt:10362/154946
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Chitosan scaffolds with mesoporous hydroxyapatite and mesoporous bioactive glassBone tissue engineeringChitosanMesoporous bioactive glassMesoporous hydroxyapatiteScaffoldBiomaterialsChemical Engineering (miscellaneous)Publisher Copyright: © 2023, The Author(s).Bone regeneration is one of the most well-known fields in tissue regeneration. The major focus concerns polymeric/ceramic composite scaffolds. In this work, several composite scaffolds based on chitosan (CH), with low and high molecular weights, and different concentrations of ceramics like mesoporous bioactive glass (MBG), mesoporous hydroxyapatite (MHAp) and both MBG and MHAp (MC) were produced by lyophilization. The purpose is to identify the best combination regarding optimal morphology and properties. The tests of the scaffolds present a highly porous structure with interconnected pores. The compression modulus increases with ceramic concentration in the scaffolds. Furthermore, the 75%MBG (835 ± 160 kPa) and 50%MC (1070 ± 205 kPa) samples are the ones that mostly enhance increases in mechanical properties. The swelling capacity increases with MBG and MC, respectively, to 700% and 900% and decreases to 400% when MHAp concentration increases. All scaffolds are non-cytotoxic at 12.5 mg/mL. The CHL scaffolds improve cell adhesion and proliferation compared to CHH, and the MC scaffold samples, show better results than those produced with just MBG or MHAp. The composite scaffolds of chitosan with MBG and MHAp, have revealed to be the best combination due to their enhanced performance in bone tissue engineering.DCM - Departamento de Ciência dos MateriaisCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)DF – Departamento de FísicaRUNPádua, Ana SofiaFigueiredo, LígiaSilva, Jorge CarvalhoBorges, João Paulo2023-07-06T22:18:55Z2023-062023-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article17application/pdfhttp://hdl.handle.net/10362/154946eng2194-0509PURE: 65375684https://doi.org/10.1007/s40204-023-00217-xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:37:28Zoai:run.unl.pt:10362/154946Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:55:52.149083Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Chitosan scaffolds with mesoporous hydroxyapatite and mesoporous bioactive glass
title Chitosan scaffolds with mesoporous hydroxyapatite and mesoporous bioactive glass
spellingShingle Chitosan scaffolds with mesoporous hydroxyapatite and mesoporous bioactive glass
Pádua, Ana Sofia
Bone tissue engineering
Chitosan
Mesoporous bioactive glass
Mesoporous hydroxyapatite
Scaffold
Biomaterials
Chemical Engineering (miscellaneous)
title_short Chitosan scaffolds with mesoporous hydroxyapatite and mesoporous bioactive glass
title_full Chitosan scaffolds with mesoporous hydroxyapatite and mesoporous bioactive glass
title_fullStr Chitosan scaffolds with mesoporous hydroxyapatite and mesoporous bioactive glass
title_full_unstemmed Chitosan scaffolds with mesoporous hydroxyapatite and mesoporous bioactive glass
title_sort Chitosan scaffolds with mesoporous hydroxyapatite and mesoporous bioactive glass
author Pádua, Ana Sofia
author_facet Pádua, Ana Sofia
Figueiredo, Lígia
Silva, Jorge Carvalho
Borges, João Paulo
author_role author
author2 Figueiredo, Lígia
Silva, Jorge Carvalho
Borges, João Paulo
author2_role author
author
author
dc.contributor.none.fl_str_mv DCM - Departamento de Ciência dos Materiais
CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
DF – Departamento de Física
RUN
dc.contributor.author.fl_str_mv Pádua, Ana Sofia
Figueiredo, Lígia
Silva, Jorge Carvalho
Borges, João Paulo
dc.subject.por.fl_str_mv Bone tissue engineering
Chitosan
Mesoporous bioactive glass
Mesoporous hydroxyapatite
Scaffold
Biomaterials
Chemical Engineering (miscellaneous)
topic Bone tissue engineering
Chitosan
Mesoporous bioactive glass
Mesoporous hydroxyapatite
Scaffold
Biomaterials
Chemical Engineering (miscellaneous)
description Publisher Copyright: © 2023, The Author(s).
publishDate 2023
dc.date.none.fl_str_mv 2023-07-06T22:18:55Z
2023-06
2023-06-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/154946
url http://hdl.handle.net/10362/154946
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2194-0509
PURE: 65375684
https://doi.org/10.1007/s40204-023-00217-x
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 17
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799138145174814720

Registros relacionados