Telomerase Is Required for Zebrafish Lifespan

• Autor(a) principal: Henriques, Catarina M.
• Data de Publicação: 2013
• Outros Autores: Carneiro, Madalena C., Tenente, Inês M., Jacinto, António, Ferreira, Miguel Godinho
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• DOI: 10.1371/journal.pgen.1003214
• Texto Completo: https://doi.org/10.1371/journal.pgen.1003214
• topic: DNA-DAMAGE-RESPONSE; DYSFUNCTIONAL TELOMERES; STEM-CELLS; CANCER; MICE; SENESCENCE; APOPTOSIS; LENGTH; AGE; PATHWAYS; Ecology, Evolution, Behavior and Systematics; Molecular Biology; Genetics; Genetics(clinical); Cancer Research; SDG 3 - Good Health and Well-being

CMH and MCC are supported by the Portuguese Fundacao para a Ciencia e a Tecnologia (FCT) fellowships. This work was supported by the FCT (PTDC/SAU-ORG/116826/2010 and PTDC/SAU-ONC/116821/2 010) and the Howard Hughes Medical Institute. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We indebted to Prisca Chapouton, Susanne Sprungala, and Laure Bally-Cuif for communicating results and sharing reagents prior to publication. We thank Drs. Cuppen and Plasterk (Hubrecht Laboratory) and Dr. Stemple (Welcome Trust Sanger Institute) for providing the zebrafish knockout mutant, which was generated as part of the ZF- MODELS Integrated Project in the 6th Framework Programme (Contract No. LSHG-CT-2003-503496) funded by the European Commission. We are grateful to Joana Nabais, Sofia Esteves, Rita Mateus, Sofia Azevedo, Susana Lopes, and Leonor Saude for help at the initial stages of our work; Tania Carvalho for histopathological analysis; Clara Melo, Graeme Hewitt, and Joao Passos for help with the Telo-FISH. We thank Joao Passos and Lea Harrington for critically reading the manuscript. MGF is a HHMI International Early Career Scientist.