Synthesis of chromone-related pyrazole compounds

Detalhes bibliográficos
Autor(a) principal: Santos, Clementina M.M.
Data de Publicação: 2017
Outros Autores: Silva, Vera L.M., Silva, Artur
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10198/20460
Resumo: Chromones, six-membered oxygen heterocycles, and pyrazoles, five-membered two-adjacent-nitrogen-containing heterocycles, represent two important classes of biologically active compounds. Certain derivatives of these scaffolds play an important role in medicinal chemistry and have been extensively used as versatile building blocks in organic synthesis. In this context, we will discuss the most relevant advances on the chemistry that involves both chromone and pyrazole rings. The methods reviewed include the synthesis of chromone-pyrazole dyads, synthesis of chromone-pyrazole-fused compounds, and chromones as starting materials in the synthesis of 3(5)-(2-hydroxyaryl)pyrazoles, among others. This review will cover the literature on the chromone and pyrazole dual chemistry and their outcomes in the 21st century.
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spelling Synthesis of chromone-related pyrazole compoundsAntineoplastic agentsChromonesDrug designHumansMolecular structurePyrazolesStructure-activity relationshipChromones, six-membered oxygen heterocycles, and pyrazoles, five-membered two-adjacent-nitrogen-containing heterocycles, represent two important classes of biologically active compounds. Certain derivatives of these scaffolds play an important role in medicinal chemistry and have been extensively used as versatile building blocks in organic synthesis. In this context, we will discuss the most relevant advances on the chemistry that involves both chromone and pyrazole rings. The methods reviewed include the synthesis of chromone-pyrazole dyads, synthesis of chromone-pyrazole-fused compounds, and chromones as starting materials in the synthesis of 3(5)-(2-hydroxyaryl)pyrazoles, among others. This review will cover the literature on the chromone and pyrazole dual chemistry and their outcomes in the 21st century.Thanks are due to University of Aveiro and FCT/MEC for the financial support of the QOPNA research unit (FCT UID/QUI/00062/2013) and CIQ-UP, University of Porto (POCI-01-0145-FEDER-006980; FCT: UID/QUI/00081/2013) through national founds and, where applicable, co-financed by the FEDER, within the PT2020 Partnership Agreement, as well as to the Polytechnic Institute of Bragança. V.L.M.S. is grateful to FCT for her grant (SFRH/BPD/108807/2015), in the ambit of “QREN e POCH e Tipologia 4.1 e Formação Avançada”, co-sponsored by FSE and by national funds of MCTES.Biblioteca Digital do IPBSantos, Clementina M.M.Silva, Vera L.M.Silva, Artur2020-01-21T16:30:50Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/20460engSantos, Clementina M.M.; Silva, Vera L.M.; Silva, Artur (2017). Synthesis of chromone-related pyrazole compounds. Molecules. ISSN 1420-3049. 22:10, p. 1-471420-304910.3390/molecules22101665info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:46:26Zoai:bibliotecadigital.ipb.pt:10198/20460Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:11:13.094722Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Synthesis of chromone-related pyrazole compounds
title Synthesis of chromone-related pyrazole compounds
spellingShingle Synthesis of chromone-related pyrazole compounds
Santos, Clementina M.M.
Antineoplastic agents
Chromones
Drug design
Humans
Molecular structure
Pyrazoles
Structure-activity relationship
title_short Synthesis of chromone-related pyrazole compounds
title_full Synthesis of chromone-related pyrazole compounds
title_fullStr Synthesis of chromone-related pyrazole compounds
title_full_unstemmed Synthesis of chromone-related pyrazole compounds
title_sort Synthesis of chromone-related pyrazole compounds
author Santos, Clementina M.M.
author_facet Santos, Clementina M.M.
Silva, Vera L.M.
Silva, Artur
author_role author
author2 Silva, Vera L.M.
Silva, Artur
author2_role author
author
dc.contributor.none.fl_str_mv Biblioteca Digital do IPB
dc.contributor.author.fl_str_mv Santos, Clementina M.M.
Silva, Vera L.M.
Silva, Artur
dc.subject.por.fl_str_mv Antineoplastic agents
Chromones
Drug design
Humans
Molecular structure
Pyrazoles
Structure-activity relationship
topic Antineoplastic agents
Chromones
Drug design
Humans
Molecular structure
Pyrazoles
Structure-activity relationship
description Chromones, six-membered oxygen heterocycles, and pyrazoles, five-membered two-adjacent-nitrogen-containing heterocycles, represent two important classes of biologically active compounds. Certain derivatives of these scaffolds play an important role in medicinal chemistry and have been extensively used as versatile building blocks in organic synthesis. In this context, we will discuss the most relevant advances on the chemistry that involves both chromone and pyrazole rings. The methods reviewed include the synthesis of chromone-pyrazole dyads, synthesis of chromone-pyrazole-fused compounds, and chromones as starting materials in the synthesis of 3(5)-(2-hydroxyaryl)pyrazoles, among others. This review will cover the literature on the chromone and pyrazole dual chemistry and their outcomes in the 21st century.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
2020-01-21T16:30:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10198/20460
url http://hdl.handle.net/10198/20460
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Santos, Clementina M.M.; Silva, Vera L.M.; Silva, Artur (2017). Synthesis of chromone-related pyrazole compounds. Molecules. ISSN 1420-3049. 22:10, p. 1-47
1420-3049
10.3390/molecules22101665
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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