Cholesterol is Inefficiently Converted to Cholesteryl Esters in the Blood of Cardiovascular Disease Patients
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | https://doi.org/10.1038/s41598-018-33116-4 |
Resumo: | We thank the nursing staff at the Hospital Santa Cruz, in particular Edite Tomas Mateus and Manuel Belo Costa for their enthusiastic involvement in this project and help in blood collection. This work was supported by iNOVA4Health - UID/Multi/04462/2013, a program financially supported by FCT (Foundation for Science and Technology of the Portuguese Ministry of Science and Higher Education) through national funds and co-funded by FEDER under the PT2020 Partnership, and Programas de Atividades Conjuntas (PAC) (Ref. No 03/SAICT/2015). ND is a holder of PhD fellowship from the FCT (Ref. No: SFRH/BD/51877/2012). |
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Cholesterol is Inefficiently Converted to Cholesteryl Esters in the Blood of Cardiovascular Disease PatientsGeneralSDG 3 - Good Health and Well-beingWe thank the nursing staff at the Hospital Santa Cruz, in particular Edite Tomas Mateus and Manuel Belo Costa for their enthusiastic involvement in this project and help in blood collection. This work was supported by iNOVA4Health - UID/Multi/04462/2013, a program financially supported by FCT (Foundation for Science and Technology of the Portuguese Ministry of Science and Higher Education) through national funds and co-funded by FEDER under the PT2020 Partnership, and Programas de Atividades Conjuntas (PAC) (Ref. No 03/SAICT/2015). ND is a holder of PhD fellowship from the FCT (Ref. No: SFRH/BD/51877/2012).Shotgun lipidomic analysis of 203 lipids in 13 lipid classes performed on blood plasma of donors who had just suffered an acute coronary syndrome (ACS, n = 74), or an ischemic stroke (IS, n = 21), or who suffer from stable angina pectoris (SAP, n = 78), and an age-matched control cohort (n = 52), showed some of the highest inter-lipid class correlations between cholesteryl esters (CE) and phosphatidylcholines (PC) sharing a common fatty acid. The concentration of lysophospatidylcholine (LPC) and ratios of concentrations of CE to free cholesterol (Chol) were also lower in the CVD cohorts than in the control cohort, indicating a deficient conversion of Chol to CE in the blood plasma in the CVD subjects. A non-equilibrium reaction quotient, Q′, describing the global homeostasis of cholesterol as manifested in the blood plasma was shown to have a value in the CVD cohorts (Q′ACS = 0.217 ± 0.084; Q′IS = 0.201 ± 0.084; Q′SAP = 0.220 ± 0.071) that was about one third less than in the control cohort (Q′Control = 0.320 ± 0.095, p < 1 × 10−4), suggesting its potential use as a rapid predictive/diagnostic measure of CVD-related irregularities in cholesterol homeostasis.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNGerl, Mathias J.Vaz, Winchil L.C.Domingues, NeuzaKlose, ChristianSurma, Michal A.Sampaio, Júlio L.Almeida, Manuel S.Rodrigues, GustavoAraújo-Gonçalves, PedroFerreira, JorgeBorbinha, ClaudiaMarto, João PedroViana-Baptista, MiguelSimons, KaiVieira, Otilia V.2018-10-22T22:10:11Z2018-12-012018-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.1038/s41598-018-33116-4eng2045-2322PURE: 6062628http://www.scopus.com/inward/record.url?scp=85054331340&partnerID=8YFLogxKhttps://doi.org/10.1038/s41598-018-33116-4info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:25:14Zoai:run.unl.pt:10362/49617Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:32:14.774751Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Cholesterol is Inefficiently Converted to Cholesteryl Esters in the Blood of Cardiovascular Disease Patients |
| title |
Cholesterol is Inefficiently Converted to Cholesteryl Esters in the Blood of Cardiovascular Disease Patients |
| spellingShingle |
Cholesterol is Inefficiently Converted to Cholesteryl Esters in the Blood of Cardiovascular Disease Patients Gerl, Mathias J. General SDG 3 - Good Health and Well-being |
| title_short |
Cholesterol is Inefficiently Converted to Cholesteryl Esters in the Blood of Cardiovascular Disease Patients |
| title_full |
Cholesterol is Inefficiently Converted to Cholesteryl Esters in the Blood of Cardiovascular Disease Patients |
| title_fullStr |
Cholesterol is Inefficiently Converted to Cholesteryl Esters in the Blood of Cardiovascular Disease Patients |
| title_full_unstemmed |
Cholesterol is Inefficiently Converted to Cholesteryl Esters in the Blood of Cardiovascular Disease Patients |
| title_sort |
Cholesterol is Inefficiently Converted to Cholesteryl Esters in the Blood of Cardiovascular Disease Patients |
| author |
Gerl, Mathias J. |
| author_facet |
Gerl, Mathias J. Vaz, Winchil L.C. Domingues, Neuza Klose, Christian Surma, Michal A. Sampaio, Júlio L. Almeida, Manuel S. Rodrigues, Gustavo Araújo-Gonçalves, Pedro Ferreira, Jorge Borbinha, Claudia Marto, João Pedro Viana-Baptista, Miguel Simons, Kai Vieira, Otilia V. |
| author_role |
author |
| author2 |
Vaz, Winchil L.C. Domingues, Neuza Klose, Christian Surma, Michal A. Sampaio, Júlio L. Almeida, Manuel S. Rodrigues, Gustavo Araújo-Gonçalves, Pedro Ferreira, Jorge Borbinha, Claudia Marto, João Pedro Viana-Baptista, Miguel Simons, Kai Vieira, Otilia V. |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Centro de Estudos de Doenças Crónicas (CEDOC) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Gerl, Mathias J. Vaz, Winchil L.C. Domingues, Neuza Klose, Christian Surma, Michal A. Sampaio, Júlio L. Almeida, Manuel S. Rodrigues, Gustavo Araújo-Gonçalves, Pedro Ferreira, Jorge Borbinha, Claudia Marto, João Pedro Viana-Baptista, Miguel Simons, Kai Vieira, Otilia V. |
| dc.subject.por.fl_str_mv |
General SDG 3 - Good Health and Well-being |
| topic |
General SDG 3 - Good Health and Well-being |
| description |
We thank the nursing staff at the Hospital Santa Cruz, in particular Edite Tomas Mateus and Manuel Belo Costa for their enthusiastic involvement in this project and help in blood collection. This work was supported by iNOVA4Health - UID/Multi/04462/2013, a program financially supported by FCT (Foundation for Science and Technology of the Portuguese Ministry of Science and Higher Education) through national funds and co-funded by FEDER under the PT2020 Partnership, and Programas de Atividades Conjuntas (PAC) (Ref. No 03/SAICT/2015). ND is a holder of PhD fellowship from the FCT (Ref. No: SFRH/BD/51877/2012). |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018-10-22T22:10:11Z 2018-12-01 2018-12-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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https://doi.org/10.1038/s41598-018-33116-4 |
| url |
https://doi.org/10.1038/s41598-018-33116-4 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2045-2322 PURE: 6062628 http://www.scopus.com/inward/record.url?scp=85054331340&partnerID=8YFLogxK https://doi.org/10.1038/s41598-018-33116-4 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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