Melanin’s Journey from Melanocytes to Keratinocytes: Uncovering the Molecular Mechanisms of Melanin Transfer and Processing

Detalhes bibliográficos
Autor(a) principal: Bento-Lopes, Liliana
Data de Publicação: 2023
Outros Autores: Cabaço, Luís C., Charneca, João, Neto, Matilde V., Seabra, Miguel C., Barral, Duarte C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/155909
Resumo: Funding This research was funded by Fundação para a Ciência e a Tecnologia (Portugal) grant number PTDC/BIA-CEL/29765/2017 and Ph.D. fellowships to L.B.-L., L.C.C., M.V.N. and J.C. (numbers SFRH/BD/131938/2017, 2020.08812.BD, PD/BD/137442/2018, and PD/BD/136905/2018, respectively). This work was also supported by iNOVA4Health—UIDB/04462/2020 and UIDP/04462/2020—and by the Associated Laboratory LS4FUTURE (LA/P/0087/2020), two programs financially supported by Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior (Portugal).
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spelling Melanin’s Journey from Melanocytes to Keratinocytes: Uncovering the Molecular Mechanisms of Melanin Transfer and Processingkeratinocytemelaninmelanin polarizationmelanin processingmelanin transfermelanocoremelanocytemelanokerasomemelanosomeFunding This research was funded by Fundação para a Ciência e a Tecnologia (Portugal) grant number PTDC/BIA-CEL/29765/2017 and Ph.D. fellowships to L.B.-L., L.C.C., M.V.N. and J.C. (numbers SFRH/BD/131938/2017, 2020.08812.BD, PD/BD/137442/2018, and PD/BD/136905/2018, respectively). This work was also supported by iNOVA4Health—UIDB/04462/2020 and UIDP/04462/2020—and by the Associated Laboratory LS4FUTURE (LA/P/0087/2020), two programs financially supported by Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior (Portugal).Skin pigmentation ensures efficient photoprotection and relies on the pigment melanin, which is produced by epidermal melanocytes and transferred to surrounding keratinocytes. While the molecular mechanisms of melanin synthesis and transport in melanocytes are now well characterized, much less is known about melanin transfer and processing within keratinocytes. Over the past few decades, distinct models have been proposed to explain how melanin transfer occurs at the cellular and molecular levels. However, this remains a debated topic, as up to four different models have been proposed, with evidence presented supporting each. Here, we review the current knowledge on the regulation of melanin exocytosis, internalization, processing, and polarization. Regarding the different transfer models, we discuss how these might co-exist to regulate skin pigmentation under different conditions, i.e., constitutive and facultative skin pigmentation or physiological and pathological conditions. Moreover, we discuss recent evidence that sheds light on the regulation of melanin exocytosis by melanocytes and internalization by keratinocytes, as well as how melanin is stored within these cells in a compartment that we propose be named the melanokerasome. Finally, we review the state of the art on the molecular mechanisms that lead to melanokerasome positioning above the nuclei of keratinocytes, forming supranuclear caps that shield the nuclear DNA from UV radiation. Thus, we provide a comprehensive overview of the current knowledge on the molecular mechanisms regulating skin pigmentation, from melanin exocytosis by melanocytes and internalization by keratinocytes to processing and polarization within keratinocytes. A better knowledge of these molecular mechanisms will clarify long-lasting questions in the field that are crucial for the understanding of skin pigmentation and can shed light on fundamental aspects of organelle biology. Ultimately, this knowledge can lead to novel therapeutic strategies to treat hypo- or hyper-pigmentation disorders, which have a high socio-economic burden on patients and healthcare systems worldwide, as well as cosmetic applications.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)iNOVA4Health - pólo NMSRUNBento-Lopes, LilianaCabaço, Luís C.Charneca, JoãoNeto, Matilde V.Seabra, Miguel C.Barral, Duarte C.2023-07-27T22:15:45Z2023-07-102023-07-10T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/155909eng1422-0067PURE: 66779741https://doi.org/10.3390/ijms241411289info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:38:29Zoai:run.unl.pt:10362/155909Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:56:15.660874Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Melanin’s Journey from Melanocytes to Keratinocytes: Uncovering the Molecular Mechanisms of Melanin Transfer and Processing
title Melanin’s Journey from Melanocytes to Keratinocytes: Uncovering the Molecular Mechanisms of Melanin Transfer and Processing
spellingShingle Melanin’s Journey from Melanocytes to Keratinocytes: Uncovering the Molecular Mechanisms of Melanin Transfer and Processing
Bento-Lopes, Liliana
keratinocyte
melanin
melanin polarization
melanin processing
melanin transfer
melanocore
melanocyte
melanokerasome
melanosome
title_short Melanin’s Journey from Melanocytes to Keratinocytes: Uncovering the Molecular Mechanisms of Melanin Transfer and Processing
title_full Melanin’s Journey from Melanocytes to Keratinocytes: Uncovering the Molecular Mechanisms of Melanin Transfer and Processing
title_fullStr Melanin’s Journey from Melanocytes to Keratinocytes: Uncovering the Molecular Mechanisms of Melanin Transfer and Processing
title_full_unstemmed Melanin’s Journey from Melanocytes to Keratinocytes: Uncovering the Molecular Mechanisms of Melanin Transfer and Processing
title_sort Melanin’s Journey from Melanocytes to Keratinocytes: Uncovering the Molecular Mechanisms of Melanin Transfer and Processing
author Bento-Lopes, Liliana
author_facet Bento-Lopes, Liliana
Cabaço, Luís C.
Charneca, João
Neto, Matilde V.
Seabra, Miguel C.
Barral, Duarte C.
author_role author
author2 Cabaço, Luís C.
Charneca, João
Neto, Matilde V.
Seabra, Miguel C.
Barral, Duarte C.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
iNOVA4Health - pólo NMS
RUN
dc.contributor.author.fl_str_mv Bento-Lopes, Liliana
Cabaço, Luís C.
Charneca, João
Neto, Matilde V.
Seabra, Miguel C.
Barral, Duarte C.
dc.subject.por.fl_str_mv keratinocyte
melanin
melanin polarization
melanin processing
melanin transfer
melanocore
melanocyte
melanokerasome
melanosome
topic keratinocyte
melanin
melanin polarization
melanin processing
melanin transfer
melanocore
melanocyte
melanokerasome
melanosome
description Funding This research was funded by Fundação para a Ciência e a Tecnologia (Portugal) grant number PTDC/BIA-CEL/29765/2017 and Ph.D. fellowships to L.B.-L., L.C.C., M.V.N. and J.C. (numbers SFRH/BD/131938/2017, 2020.08812.BD, PD/BD/137442/2018, and PD/BD/136905/2018, respectively). This work was also supported by iNOVA4Health—UIDB/04462/2020 and UIDP/04462/2020—and by the Associated Laboratory LS4FUTURE (LA/P/0087/2020), two programs financially supported by Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior (Portugal).
publishDate 2023
dc.date.none.fl_str_mv 2023-07-27T22:15:45Z
2023-07-10
2023-07-10T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/155909
url http://hdl.handle.net/10362/155909
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1422-0067
PURE: 66779741
https://doi.org/10.3390/ijms241411289
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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