Impact of tRNA modifications and tRNA-modifying enzymes on proteostasis and human disease
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/27447 |
Resumo: | Transfer RNAs (tRNAs) are key players of protein synthesis, as they decode the genetic information organized in mRNA codons, translating them into the code of 20 amino acids. To be fully active, tRNAs undergo extensive post-transcriptional modifications, catalyzed by different tRNA-modifying enzymes. Lack of these modifications increases the level of missense errors and affects codon decoding rate, contributing to protein aggregation with deleterious consequences to the cell. Recent works show that tRNA hypomodification and tRNA-modifying-enzyme deregulation occur in several diseases where proteostasis is affected, namely, neurodegenerative and metabolic diseases. In this review, we discuss the recent findings that correlate aberrant tRNA modification with proteostasis imbalances, in particular in neurological and metabolic disorders, and highlight the association between tRNAs, their modifying enzymes, translational decoding, and disease onset. |
id |
RCAP_8e084e4254013119482561115695b448 |
---|---|
oai_identifier_str |
oai:ria.ua.pt:10773/27447 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Impact of tRNA modifications and tRNA-modifying enzymes on proteostasis and human diseaseTransfer RNAtRNA modificationstRNA-modifying enzymesProteostasisConformational disordersTranslationProtein aggregationMetabolic diseasesNervous system diseasesNucleic acid conformationtRNA methyltransferasesProtein biosynthesisRNA processing, post-transcriptionalTransfer RNAs (tRNAs) are key players of protein synthesis, as they decode the genetic information organized in mRNA codons, translating them into the code of 20 amino acids. To be fully active, tRNAs undergo extensive post-transcriptional modifications, catalyzed by different tRNA-modifying enzymes. Lack of these modifications increases the level of missense errors and affects codon decoding rate, contributing to protein aggregation with deleterious consequences to the cell. Recent works show that tRNA hypomodification and tRNA-modifying-enzyme deregulation occur in several diseases where proteostasis is affected, namely, neurodegenerative and metabolic diseases. In this review, we discuss the recent findings that correlate aberrant tRNA modification with proteostasis imbalances, in particular in neurological and metabolic disorders, and highlight the association between tRNAs, their modifying enzymes, translational decoding, and disease onset.MDPI2020-01-31T17:21:06Z2018-12-01T00:00:00Z2018-12info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/27447eng1661-659610.3390/ijms19123738Pereira, MarisaFrancisco, StephanyVaranda, Ana SofiaSantos, MafaldaSantos, Manuel A. S.Soares, Ana Raquelinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:52:06Zoai:ria.ua.pt:10773/27447Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:59:47.946252Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Impact of tRNA modifications and tRNA-modifying enzymes on proteostasis and human disease |
title |
Impact of tRNA modifications and tRNA-modifying enzymes on proteostasis and human disease |
spellingShingle |
Impact of tRNA modifications and tRNA-modifying enzymes on proteostasis and human disease Pereira, Marisa Transfer RNA tRNA modifications tRNA-modifying enzymes Proteostasis Conformational disorders Translation Protein aggregation Metabolic diseases Nervous system diseases Nucleic acid conformation tRNA methyltransferases Protein biosynthesis RNA processing, post-transcriptional |
title_short |
Impact of tRNA modifications and tRNA-modifying enzymes on proteostasis and human disease |
title_full |
Impact of tRNA modifications and tRNA-modifying enzymes on proteostasis and human disease |
title_fullStr |
Impact of tRNA modifications and tRNA-modifying enzymes on proteostasis and human disease |
title_full_unstemmed |
Impact of tRNA modifications and tRNA-modifying enzymes on proteostasis and human disease |
title_sort |
Impact of tRNA modifications and tRNA-modifying enzymes on proteostasis and human disease |
author |
Pereira, Marisa |
author_facet |
Pereira, Marisa Francisco, Stephany Varanda, Ana Sofia Santos, Mafalda Santos, Manuel A. S. Soares, Ana Raquel |
author_role |
author |
author2 |
Francisco, Stephany Varanda, Ana Sofia Santos, Mafalda Santos, Manuel A. S. Soares, Ana Raquel |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Pereira, Marisa Francisco, Stephany Varanda, Ana Sofia Santos, Mafalda Santos, Manuel A. S. Soares, Ana Raquel |
dc.subject.por.fl_str_mv |
Transfer RNA tRNA modifications tRNA-modifying enzymes Proteostasis Conformational disorders Translation Protein aggregation Metabolic diseases Nervous system diseases Nucleic acid conformation tRNA methyltransferases Protein biosynthesis RNA processing, post-transcriptional |
topic |
Transfer RNA tRNA modifications tRNA-modifying enzymes Proteostasis Conformational disorders Translation Protein aggregation Metabolic diseases Nervous system diseases Nucleic acid conformation tRNA methyltransferases Protein biosynthesis RNA processing, post-transcriptional |
description |
Transfer RNAs (tRNAs) are key players of protein synthesis, as they decode the genetic information organized in mRNA codons, translating them into the code of 20 amino acids. To be fully active, tRNAs undergo extensive post-transcriptional modifications, catalyzed by different tRNA-modifying enzymes. Lack of these modifications increases the level of missense errors and affects codon decoding rate, contributing to protein aggregation with deleterious consequences to the cell. Recent works show that tRNA hypomodification and tRNA-modifying-enzyme deregulation occur in several diseases where proteostasis is affected, namely, neurodegenerative and metabolic diseases. In this review, we discuss the recent findings that correlate aberrant tRNA modification with proteostasis imbalances, in particular in neurological and metabolic disorders, and highlight the association between tRNAs, their modifying enzymes, translational decoding, and disease onset. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-01T00:00:00Z 2018-12 2020-01-31T17:21:06Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/27447 |
url |
http://hdl.handle.net/10773/27447 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1661-6596 10.3390/ijms19123738 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799137652626161664 |