Prevalence of pfmdr1 alleles associated with artemether-lumefantrine tolerance/resistance in Maputo before and after the implementation of artemisinin-based combination therapy

Detalhes bibliográficos
Autor(a) principal: Lobo, Elsa
Data de Publicação: 2014
Outros Autores: Sousa, Bruno de, Rosa, Soraia, Figueiredo, Paula, Lobo, Lis, Pateira, Sara, Fernandes, Natércia, Nogueira, Fátima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
DOI: 10.1186/1475-2875-13-300
Texto Completo: http://hdl.handle.net/10316/46914
https://doi.org/10.1186/1475-2875-13-300
Resumo: Mozambique implemented artemisinin-based combinations therapy (ACT) using artemether-lumefantrine (AL) as the first-line treatment for uncomplicated malaria in 2009. AL remains highly efficacious, but widespread use may soon facilitate emergence of artemisinin tolerance/resistance. The prevalence of pfmdr1 different alleles in Maputo and Mozambique is not known, either after or before the introduction of ACT. Pfmdr1 molecular markers related to Plasmodium falciparum susceptibility were analysed before and after transition to ACT.
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spelling Prevalence of pfmdr1 alleles associated with artemether-lumefantrine tolerance/resistance in Maputo before and after the implementation of artemisinin-based combination therapyArtemisininsDrug CombinationsDrug ResistanceEthanolaminesFluorenesHaplotypesHumansMalaria, FalciparumMozambiqueMultidrug Resistance-Associated ProteinsPlasmodium falciparumPolymorphism, Single NucleotidePrevalenceMozambique implemented artemisinin-based combinations therapy (ACT) using artemether-lumefantrine (AL) as the first-line treatment for uncomplicated malaria in 2009. AL remains highly efficacious, but widespread use may soon facilitate emergence of artemisinin tolerance/resistance. The prevalence of pfmdr1 different alleles in Maputo and Mozambique is not known, either after or before the introduction of ACT. Pfmdr1 molecular markers related to Plasmodium falciparum susceptibility were analysed before and after transition to ACT.2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/46914http://hdl.handle.net/10316/46914https://doi.org/10.1186/1475-2875-13-300engLobo, ElsaSousa, Bruno deRosa, SoraiaFigueiredo, PaulaLobo, LisPateira, SaraFernandes, NatérciaNogueira, Fátimainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-10-04T09:56:09Zoai:estudogeral.uc.pt:10316/46914Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:53:00.876680Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Prevalence of pfmdr1 alleles associated with artemether-lumefantrine tolerance/resistance in Maputo before and after the implementation of artemisinin-based combination therapy
title Prevalence of pfmdr1 alleles associated with artemether-lumefantrine tolerance/resistance in Maputo before and after the implementation of artemisinin-based combination therapy
spellingShingle Prevalence of pfmdr1 alleles associated with artemether-lumefantrine tolerance/resistance in Maputo before and after the implementation of artemisinin-based combination therapy
Prevalence of pfmdr1 alleles associated with artemether-lumefantrine tolerance/resistance in Maputo before and after the implementation of artemisinin-based combination therapy
Lobo, Elsa
Artemisinins
Drug Combinations
Drug Resistance
Ethanolamines
Fluorenes
Haplotypes
Humans
Malaria, Falciparum
Mozambique
Multidrug Resistance-Associated Proteins
Plasmodium falciparum
Polymorphism, Single Nucleotide
Prevalence
Lobo, Elsa
Artemisinins
Drug Combinations
Drug Resistance
Ethanolamines
Fluorenes
Haplotypes
Humans
Malaria, Falciparum
Mozambique
Multidrug Resistance-Associated Proteins
Plasmodium falciparum
Polymorphism, Single Nucleotide
Prevalence
title_short Prevalence of pfmdr1 alleles associated with artemether-lumefantrine tolerance/resistance in Maputo before and after the implementation of artemisinin-based combination therapy
title_full Prevalence of pfmdr1 alleles associated with artemether-lumefantrine tolerance/resistance in Maputo before and after the implementation of artemisinin-based combination therapy
title_fullStr Prevalence of pfmdr1 alleles associated with artemether-lumefantrine tolerance/resistance in Maputo before and after the implementation of artemisinin-based combination therapy
Prevalence of pfmdr1 alleles associated with artemether-lumefantrine tolerance/resistance in Maputo before and after the implementation of artemisinin-based combination therapy
title_full_unstemmed Prevalence of pfmdr1 alleles associated with artemether-lumefantrine tolerance/resistance in Maputo before and after the implementation of artemisinin-based combination therapy
Prevalence of pfmdr1 alleles associated with artemether-lumefantrine tolerance/resistance in Maputo before and after the implementation of artemisinin-based combination therapy
title_sort Prevalence of pfmdr1 alleles associated with artemether-lumefantrine tolerance/resistance in Maputo before and after the implementation of artemisinin-based combination therapy
author Lobo, Elsa
author_facet Lobo, Elsa
Lobo, Elsa
Sousa, Bruno de
Rosa, Soraia
Figueiredo, Paula
Lobo, Lis
Pateira, Sara
Fernandes, Natércia
Nogueira, Fátima
Sousa, Bruno de
Rosa, Soraia
Figueiredo, Paula
Lobo, Lis
Pateira, Sara
Fernandes, Natércia
Nogueira, Fátima
author_role author
author2 Sousa, Bruno de
Rosa, Soraia
Figueiredo, Paula
Lobo, Lis
Pateira, Sara
Fernandes, Natércia
Nogueira, Fátima
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lobo, Elsa
Sousa, Bruno de
Rosa, Soraia
Figueiredo, Paula
Lobo, Lis
Pateira, Sara
Fernandes, Natércia
Nogueira, Fátima
dc.subject.por.fl_str_mv Artemisinins
Drug Combinations
Drug Resistance
Ethanolamines
Fluorenes
Haplotypes
Humans
Malaria, Falciparum
Mozambique
Multidrug Resistance-Associated Proteins
Plasmodium falciparum
Polymorphism, Single Nucleotide
Prevalence
topic Artemisinins
Drug Combinations
Drug Resistance
Ethanolamines
Fluorenes
Haplotypes
Humans
Malaria, Falciparum
Mozambique
Multidrug Resistance-Associated Proteins
Plasmodium falciparum
Polymorphism, Single Nucleotide
Prevalence
description Mozambique implemented artemisinin-based combinations therapy (ACT) using artemether-lumefantrine (AL) as the first-line treatment for uncomplicated malaria in 2009. AL remains highly efficacious, but widespread use may soon facilitate emergence of artemisinin tolerance/resistance. The prevalence of pfmdr1 different alleles in Maputo and Mozambique is not known, either after or before the introduction of ACT. Pfmdr1 molecular markers related to Plasmodium falciparum susceptibility were analysed before and after transition to ACT.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/46914
http://hdl.handle.net/10316/46914
https://doi.org/10.1186/1475-2875-13-300
url http://hdl.handle.net/10316/46914
https://doi.org/10.1186/1475-2875-13-300
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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dc.identifier.doi.none.fl_str_mv 10.1186/1475-2875-13-300

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