Structural and functional studies on enzymes involved in microbial hydrogen sulfide metabolism

Detalhes bibliográficos
Autor(a) principal: Almeida Cordeiro, Rafaela
Data de Publicação: 2023
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/163214
Resumo: "Hydrogen sulfide has a physiological role in the human organism. The tight control and balance of its metabolism is very important since high concentrations of bacterial-derived H2S confers them increased resistance to host leukocytes. Infections caused by Staphylococcus (S.) aureus are very common at present and are associated with resistant strains. S. aureus has a cst operon that encodes proteins responsible for maintaining the tight balance in H2S metab-olism. One of these proteins is SQR, responsible for the first step of H2S detoxification. In collaboration with Giedroc's lab, the major aim of this project is to biochemically and structurally characterize the SQR protein from S. aureus (SaSQR).(...)"
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spelling Structural and functional studies on enzymes involved in microbial hydrogen sulfide metabolismStaphylococcus aureusantibiotic resistancehydrogen sulfide (H2S)cst operonDomínio/Área Científica::Ciências Naturais"Hydrogen sulfide has a physiological role in the human organism. The tight control and balance of its metabolism is very important since high concentrations of bacterial-derived H2S confers them increased resistance to host leukocytes. Infections caused by Staphylococcus (S.) aureus are very common at present and are associated with resistant strains. S. aureus has a cst operon that encodes proteins responsible for maintaining the tight balance in H2S metab-olism. One of these proteins is SQR, responsible for the first step of H2S detoxification. In collaboration with Giedroc's lab, the major aim of this project is to biochemically and structurally characterize the SQR protein from S. aureus (SaSQR).(...)"Brito, JoséVicente, JoãoRUNAlmeida Cordeiro, Rafaela2024-02-07T16:06:02Z2023-12-152023-09-012023-12-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10362/163214TID:203518764enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:46:20Zoai:run.unl.pt:10362/163214Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:59:18.946931Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Structural and functional studies on enzymes involved in microbial hydrogen sulfide metabolism
title Structural and functional studies on enzymes involved in microbial hydrogen sulfide metabolism
spellingShingle Structural and functional studies on enzymes involved in microbial hydrogen sulfide metabolism
Almeida Cordeiro, Rafaela
Staphylococcus aureus
antibiotic resistance
hydrogen sulfide (H2S)
cst operon
Domínio/Área Científica::Ciências Naturais
title_short Structural and functional studies on enzymes involved in microbial hydrogen sulfide metabolism
title_full Structural and functional studies on enzymes involved in microbial hydrogen sulfide metabolism
title_fullStr Structural and functional studies on enzymes involved in microbial hydrogen sulfide metabolism
title_full_unstemmed Structural and functional studies on enzymes involved in microbial hydrogen sulfide metabolism
title_sort Structural and functional studies on enzymes involved in microbial hydrogen sulfide metabolism
author Almeida Cordeiro, Rafaela
author_facet Almeida Cordeiro, Rafaela
author_role author
dc.contributor.none.fl_str_mv Brito, José
Vicente, João
RUN
dc.contributor.author.fl_str_mv Almeida Cordeiro, Rafaela
dc.subject.por.fl_str_mv Staphylococcus aureus
antibiotic resistance
hydrogen sulfide (H2S)
cst operon
Domínio/Área Científica::Ciências Naturais
topic Staphylococcus aureus
antibiotic resistance
hydrogen sulfide (H2S)
cst operon
Domínio/Área Científica::Ciências Naturais
description "Hydrogen sulfide has a physiological role in the human organism. The tight control and balance of its metabolism is very important since high concentrations of bacterial-derived H2S confers them increased resistance to host leukocytes. Infections caused by Staphylococcus (S.) aureus are very common at present and are associated with resistant strains. S. aureus has a cst operon that encodes proteins responsible for maintaining the tight balance in H2S metab-olism. One of these proteins is SQR, responsible for the first step of H2S detoxification. In collaboration with Giedroc's lab, the major aim of this project is to biochemically and structurally characterize the SQR protein from S. aureus (SaSQR).(...)"
publishDate 2023
dc.date.none.fl_str_mv 2023-12-15
2023-09-01
2023-12-15T00:00:00Z
2024-02-07T16:06:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/163214
TID:203518764
url http://hdl.handle.net/10362/163214
identifier_str_mv TID:203518764
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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