Perinatal Ischemic Stroke: a Five-Year Retrospective Study in a Level-III Maternity
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/2217 |
Resumo: | Objective To study the incidence, clinical presentation, risk factors, imaging diagnosis, and clinical outcome of perinatal stroke. Methods Data was retrospectively collected from full-term newborns admitted to the neonatal unit of a level III maternity in Lisbon with cerebral stroke, from January 2007 to December 2011. Results There were 11 cases of stroke: nine were arterial ischemic stroke and two were cerebral venous sinus thrombosis. We estimated an incidence of arterial ischemic stroke of 1.6/5,000 births and of cerebral venous sinus thrombosis of 7.2/100,000 births. There were two cases of recurrent stroke. Eight patients presented with symptoms while the remaining three were asymptomatic and incidentally diagnosed. The most frequently registered symptoms (8/11) were seizures; in that, generalized clonic (3/8) and focal clonic (5/8). Strokes were more commonly left-sided (9/11), and the most affected artery was the left middle cerebral artery (8/11). Transfontanelle ultrasound was positive in most of the patients (10/11), and stroke was confirmed by cerebral magnetic resonance in all patients. Electroencephalographic recordings were carried out in five patients and were abnormal in three (focal abnormalities n=2, burst-suppression pattern n=1). Eight patients had previously identified risk factors for neonatal stroke which included obstetric and neonatal causes. Ten patients were followed up at outpatients setting; four patients developed motor deficits and one presented with epilepsy. Conclusions Although a modest and heterogeneous sample, this study emphasizes the need for a high level of suspicion when it comes to neonatal stroke, primarily in the presence of risk factors. The prevalence of neurological sequelae in our series supports the need of long-term follow-up and early intervention strategies. |
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Perinatal Ischemic Stroke: a Five-Year Retrospective Study in a Level-III MaternityAcidente Vascular Cerebral Isquémico Perinatal: Estudo Retrospectivo de 5 Anos em Maternidade Nível IIIMAC PEDBrain Ischemia/diagnosisAge FactorsRisk FactorsBrain Ischemia/epidemiologyRetrospective StudiesBrain Ischemia/etiologyBrazil/epidemiologyEchoencephalographyElectroencephalographyFollow-Up StudiesInfant, NewbornMagnetic Resonance ImagingStroke/diagnosisStroke/epidemiologyStroke/etiologyTime FactorsObjective To study the incidence, clinical presentation, risk factors, imaging diagnosis, and clinical outcome of perinatal stroke. Methods Data was retrospectively collected from full-term newborns admitted to the neonatal unit of a level III maternity in Lisbon with cerebral stroke, from January 2007 to December 2011. Results There were 11 cases of stroke: nine were arterial ischemic stroke and two were cerebral venous sinus thrombosis. We estimated an incidence of arterial ischemic stroke of 1.6/5,000 births and of cerebral venous sinus thrombosis of 7.2/100,000 births. There were two cases of recurrent stroke. Eight patients presented with symptoms while the remaining three were asymptomatic and incidentally diagnosed. The most frequently registered symptoms (8/11) were seizures; in that, generalized clonic (3/8) and focal clonic (5/8). Strokes were more commonly left-sided (9/11), and the most affected artery was the left middle cerebral artery (8/11). Transfontanelle ultrasound was positive in most of the patients (10/11), and stroke was confirmed by cerebral magnetic resonance in all patients. Electroencephalographic recordings were carried out in five patients and were abnormal in three (focal abnormalities n=2, burst-suppression pattern n=1). Eight patients had previously identified risk factors for neonatal stroke which included obstetric and neonatal causes. Ten patients were followed up at outpatients setting; four patients developed motor deficits and one presented with epilepsy. Conclusions Although a modest and heterogeneous sample, this study emphasizes the need for a high level of suspicion when it comes to neonatal stroke, primarily in the presence of risk factors. The prevalence of neurological sequelae in our series supports the need of long-term follow-up and early intervention strategies.ScieloRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEMachado, VPimentel, SPinto, FNona, J2015-05-29T12:15:52Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/2217engEinstein (Sao Paulo). 2015 Jan-Mar;13(1):65-71info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-10-28T10:27:18Zoai:repositorio.chlc.pt:10400.17/2217Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-10-28T10:27:18Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Perinatal Ischemic Stroke: a Five-Year Retrospective Study in a Level-III Maternity Acidente Vascular Cerebral Isquémico Perinatal: Estudo Retrospectivo de 5 Anos em Maternidade Nível III |
title |
Perinatal Ischemic Stroke: a Five-Year Retrospective Study in a Level-III Maternity |
spellingShingle |
Perinatal Ischemic Stroke: a Five-Year Retrospective Study in a Level-III Maternity Machado, V MAC PED Brain Ischemia/diagnosis Age Factors Risk Factors Brain Ischemia/epidemiology Retrospective Studies Brain Ischemia/etiology Brazil/epidemiology Echoencephalography Electroencephalography Follow-Up Studies Infant, Newborn Magnetic Resonance Imaging Stroke/diagnosis Stroke/epidemiology Stroke/etiology Time Factors |
title_short |
Perinatal Ischemic Stroke: a Five-Year Retrospective Study in a Level-III Maternity |
title_full |
Perinatal Ischemic Stroke: a Five-Year Retrospective Study in a Level-III Maternity |
title_fullStr |
Perinatal Ischemic Stroke: a Five-Year Retrospective Study in a Level-III Maternity |
title_full_unstemmed |
Perinatal Ischemic Stroke: a Five-Year Retrospective Study in a Level-III Maternity |
title_sort |
Perinatal Ischemic Stroke: a Five-Year Retrospective Study in a Level-III Maternity |
author |
Machado, V |
author_facet |
Machado, V Pimentel, S Pinto, F Nona, J |
author_role |
author |
author2 |
Pimentel, S Pinto, F Nona, J |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Machado, V Pimentel, S Pinto, F Nona, J |
dc.subject.por.fl_str_mv |
MAC PED Brain Ischemia/diagnosis Age Factors Risk Factors Brain Ischemia/epidemiology Retrospective Studies Brain Ischemia/etiology Brazil/epidemiology Echoencephalography Electroencephalography Follow-Up Studies Infant, Newborn Magnetic Resonance Imaging Stroke/diagnosis Stroke/epidemiology Stroke/etiology Time Factors |
topic |
MAC PED Brain Ischemia/diagnosis Age Factors Risk Factors Brain Ischemia/epidemiology Retrospective Studies Brain Ischemia/etiology Brazil/epidemiology Echoencephalography Electroencephalography Follow-Up Studies Infant, Newborn Magnetic Resonance Imaging Stroke/diagnosis Stroke/epidemiology Stroke/etiology Time Factors |
description |
Objective To study the incidence, clinical presentation, risk factors, imaging diagnosis, and clinical outcome of perinatal stroke. Methods Data was retrospectively collected from full-term newborns admitted to the neonatal unit of a level III maternity in Lisbon with cerebral stroke, from January 2007 to December 2011. Results There were 11 cases of stroke: nine were arterial ischemic stroke and two were cerebral venous sinus thrombosis. We estimated an incidence of arterial ischemic stroke of 1.6/5,000 births and of cerebral venous sinus thrombosis of 7.2/100,000 births. There were two cases of recurrent stroke. Eight patients presented with symptoms while the remaining three were asymptomatic and incidentally diagnosed. The most frequently registered symptoms (8/11) were seizures; in that, generalized clonic (3/8) and focal clonic (5/8). Strokes were more commonly left-sided (9/11), and the most affected artery was the left middle cerebral artery (8/11). Transfontanelle ultrasound was positive in most of the patients (10/11), and stroke was confirmed by cerebral magnetic resonance in all patients. Electroencephalographic recordings were carried out in five patients and were abnormal in three (focal abnormalities n=2, burst-suppression pattern n=1). Eight patients had previously identified risk factors for neonatal stroke which included obstetric and neonatal causes. Ten patients were followed up at outpatients setting; four patients developed motor deficits and one presented with epilepsy. Conclusions Although a modest and heterogeneous sample, this study emphasizes the need for a high level of suspicion when it comes to neonatal stroke, primarily in the presence of risk factors. The prevalence of neurological sequelae in our series supports the need of long-term follow-up and early intervention strategies. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-05-29T12:15:52Z 2015 2015-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/2217 |
url |
http://hdl.handle.net/10400.17/2217 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Einstein (Sao Paulo). 2015 Jan-Mar;13(1):65-71 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Scielo |
publisher.none.fl_str_mv |
Scielo |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1817548643615375360 |