The Role of Liquid Biopsy in Early Diagnosis of Lung Cancer

Detalhes bibliográficos
Autor(a) principal: Freitas, C
Data de Publicação: 2021
Outros Autores: Sousa, C, Machado, F, Serino, M, Santos, V, Martins, N, Teixeira, A, Cunha, A, Pereira, T, Oliveira, HP, Costa, JL, Hespanhol, V
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/152487
Resumo: Liquid biopsy is an emerging technology with a potential role in the screening and early detection of lung cancer. Several liquid biopsy-derived biomarkers have been identified and are currently under ongoing investigation. In this article, we review the available data on the use of circulating biomarkers for the early detection of lung cancer, focusing on the circulating tumor cells, circulating cell-free DNA, circulating micro-RNAs, tumor-derived exosomes, and tumor-educated platelets, providing an overview of future potential applicability in the clinical practice. While several biomarkers have shown exciting results, diagnostic performance and clinical applicability is still limited. The combination of different biomarkers, as well as their combination with other diagnostic tools show great promise, although further research is still required to define and validate the role of liquid biopsies in clinical practice.
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spelling The Role of Liquid Biopsy in Early Diagnosis of Lung CancerCell-free DNACirculating tumor associated cellsClinical biomarkers detectionExosomesLiquid biopsyLung cancerTumor-educated plateletsLiquid biopsy is an emerging technology with a potential role in the screening and early detection of lung cancer. Several liquid biopsy-derived biomarkers have been identified and are currently under ongoing investigation. In this article, we review the available data on the use of circulating biomarkers for the early detection of lung cancer, focusing on the circulating tumor cells, circulating cell-free DNA, circulating micro-RNAs, tumor-derived exosomes, and tumor-educated platelets, providing an overview of future potential applicability in the clinical practice. While several biomarkers have shown exciting results, diagnostic performance and clinical applicability is still limited. The combination of different biomarkers, as well as their combination with other diagnostic tools show great promise, although further research is still required to define and validate the role of liquid biopsies in clinical practice.Frontiers Media20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/152487eng2234-943X10.3389/fonc.2021.634316Freitas, CSousa, CMachado, FSerino, MSantos, VMartins, NTeixeira, ACunha, APereira, TOliveira, HPCosta, JLHespanhol, Vinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T15:33:08Zoai:repositorio-aberto.up.pt:10216/152487Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:26:24.933222Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The Role of Liquid Biopsy in Early Diagnosis of Lung Cancer
title The Role of Liquid Biopsy in Early Diagnosis of Lung Cancer
spellingShingle The Role of Liquid Biopsy in Early Diagnosis of Lung Cancer
Freitas, C
Cell-free DNA
Circulating tumor associated cells
Clinical biomarkers detection
Exosomes
Liquid biopsy
Lung cancer
Tumor-educated platelets
title_short The Role of Liquid Biopsy in Early Diagnosis of Lung Cancer
title_full The Role of Liquid Biopsy in Early Diagnosis of Lung Cancer
title_fullStr The Role of Liquid Biopsy in Early Diagnosis of Lung Cancer
title_full_unstemmed The Role of Liquid Biopsy in Early Diagnosis of Lung Cancer
title_sort The Role of Liquid Biopsy in Early Diagnosis of Lung Cancer
author Freitas, C
author_facet Freitas, C
Sousa, C
Machado, F
Serino, M
Santos, V
Martins, N
Teixeira, A
Cunha, A
Pereira, T
Oliveira, HP
Costa, JL
Hespanhol, V
author_role author
author2 Sousa, C
Machado, F
Serino, M
Santos, V
Martins, N
Teixeira, A
Cunha, A
Pereira, T
Oliveira, HP
Costa, JL
Hespanhol, V
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Freitas, C
Sousa, C
Machado, F
Serino, M
Santos, V
Martins, N
Teixeira, A
Cunha, A
Pereira, T
Oliveira, HP
Costa, JL
Hespanhol, V
dc.subject.por.fl_str_mv Cell-free DNA
Circulating tumor associated cells
Clinical biomarkers detection
Exosomes
Liquid biopsy
Lung cancer
Tumor-educated platelets
topic Cell-free DNA
Circulating tumor associated cells
Clinical biomarkers detection
Exosomes
Liquid biopsy
Lung cancer
Tumor-educated platelets
description Liquid biopsy is an emerging technology with a potential role in the screening and early detection of lung cancer. Several liquid biopsy-derived biomarkers have been identified and are currently under ongoing investigation. In this article, we review the available data on the use of circulating biomarkers for the early detection of lung cancer, focusing on the circulating tumor cells, circulating cell-free DNA, circulating micro-RNAs, tumor-derived exosomes, and tumor-educated platelets, providing an overview of future potential applicability in the clinical practice. While several biomarkers have shown exciting results, diagnostic performance and clinical applicability is still limited. The combination of different biomarkers, as well as their combination with other diagnostic tools show great promise, although further research is still required to define and validate the role of liquid biopsies in clinical practice.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/152487
url https://hdl.handle.net/10216/152487
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2234-943X
10.3389/fonc.2021.634316
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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