New non-toxic biocompatible dianionic ionic liquids that enhance the solubility of oral drugs from BCS class II

Detalhes bibliográficos
Autor(a) principal: Agostinho, Daniela A. S.
Data de Publicação: 2021
Outros Autores: Santos, Filipa, Esperança, José M. S. S., Duarte, Ana R. C., Reis, Patrícia M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/135164
Resumo: IF/00621/2015
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spelling New non-toxic biocompatible dianionic ionic liquids that enhance the solubility of oral drugs from BCS class IIDianionic ionic liquidsCytotoxicityDrug deliveryBioavailabilityBCS Class II oral drugsIF/00621/2015New dianionic ionic liquids (ILs) based on carboxylic anions and ammonium cations were prepared and characterized. They were used as excipients to increase the solubility of two model oral drugs of BCS class II, ibuprofen and piroxicam. With only 0.2 mol% (≈100 mM) of [N4 1 1 2OH]2[C4H4O4], the solubility increases over 40-fold and 2-fold for ibuprofen, when compared with the parent drug for water and phosphate buffer solution (PBS) 0.01M pH=7.4, respectively. With only 0.02 mol% of [N4 1 1 2OH]2[C4H4O4] it is possible to achieve a water solubility of ≈600 mg/L, in only 5 min at 37°C, corresponding to one dose of ibuprofen that an adult can take. Piroxicam also showed an increase of 20-fold and 1.5-fold for water and PBS respectively, with [N4 1 1 2OH]2[C4H4O4] and [N4 1 1 2OH]2[C5H6O4]. The lipophilicity (logP) of both drugs decreased in the presence of these compounds. The cytotoxicity profile of several of these ILs was determined, and all except [N4 1 1 2OH]2[C3H2O4] have an IC50 higher than 100 mM for fibroblasts L929 cells.DQ - Departamento de QuímicaLAQV@REQUIMTERUNAgostinho, Daniela A. S.Santos, FilipaEsperança, José M. S. S.Duarte, Ana R. C.Reis, Patrícia M.2022-03-24T23:37:53Z2021-09-012021-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/135164eng2772-4220PURE: 41740040https://doi.org/10.1016/j.jil.2021.100003info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:13:34Zoai:run.unl.pt:10362/135164Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:48:19.667676Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv New non-toxic biocompatible dianionic ionic liquids that enhance the solubility of oral drugs from BCS class II
title New non-toxic biocompatible dianionic ionic liquids that enhance the solubility of oral drugs from BCS class II
spellingShingle New non-toxic biocompatible dianionic ionic liquids that enhance the solubility of oral drugs from BCS class II
Agostinho, Daniela A. S.
Dianionic ionic liquids
Cytotoxicity
Drug delivery
Bioavailability
BCS Class II oral drugs
title_short New non-toxic biocompatible dianionic ionic liquids that enhance the solubility of oral drugs from BCS class II
title_full New non-toxic biocompatible dianionic ionic liquids that enhance the solubility of oral drugs from BCS class II
title_fullStr New non-toxic biocompatible dianionic ionic liquids that enhance the solubility of oral drugs from BCS class II
title_full_unstemmed New non-toxic biocompatible dianionic ionic liquids that enhance the solubility of oral drugs from BCS class II
title_sort New non-toxic biocompatible dianionic ionic liquids that enhance the solubility of oral drugs from BCS class II
author Agostinho, Daniela A. S.
author_facet Agostinho, Daniela A. S.
Santos, Filipa
Esperança, José M. S. S.
Duarte, Ana R. C.
Reis, Patrícia M.
author_role author
author2 Santos, Filipa
Esperança, José M. S. S.
Duarte, Ana R. C.
Reis, Patrícia M.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv DQ - Departamento de Química
LAQV@REQUIMTE
RUN
dc.contributor.author.fl_str_mv Agostinho, Daniela A. S.
Santos, Filipa
Esperança, José M. S. S.
Duarte, Ana R. C.
Reis, Patrícia M.
dc.subject.por.fl_str_mv Dianionic ionic liquids
Cytotoxicity
Drug delivery
Bioavailability
BCS Class II oral drugs
topic Dianionic ionic liquids
Cytotoxicity
Drug delivery
Bioavailability
BCS Class II oral drugs
description IF/00621/2015
publishDate 2021
dc.date.none.fl_str_mv 2021-09-01
2021-09-01T00:00:00Z
2022-03-24T23:37:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/135164
url http://hdl.handle.net/10362/135164
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2772-4220
PURE: 41740040
https://doi.org/10.1016/j.jil.2021.100003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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