Childhood adversities and the comorbidity between mood and general medical disorders in adults

Detalhes bibliográficos
Autor(a) principal: Oliveira, José
Data de Publicação: 2021
Outros Autores: Paixão, Vítor, Cardoso, Graça, Xavier, Miguel, Caldas de Almeida, José Miguel, Oliveira-Maia, Albino J
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/141859
Resumo: Funding: The WHO World Mental Health Survey Portugal was carried out by the Department of Mental Health, NOVA Medical School, NOVA University of Lisbon, with collaboration of the CESOP–Portuguese Catholic University and was funded by the Champalimaud Foundation, the Gulbenkian Foundation, the Foundation for Science and Technology (FCT) and the Ministry of Health. TheWHO World Mental Health Survey Portugal was carried out in conjunction with the World Health Organization WMH Survey Initiative which is supported by the National Institute of Mental Health (NIMH; R01MH070884), the John D. and Catherine T. MacArthur Foundation, the Pfizer Foundation, the U.S. Public Health Service (R13-MH066849, R01-MH069864 and R01 DA016558), the Fogarty International Center (FIRCA R03-TW006481), the Pan American Health Organization, Eli Lilly and Company, OrthoMcNeil Pharmaceutical, GlaxoSmithKline and Bristol-Myers Squibb. This study was supported by a NARSAD 2018 Young Investigator Grant (ID: 27,595) awarded to J.O. and a Fundação para a Ciência e Tecnologia (FCT) grant (PTDC/MED-NEU/31,331/2017) and a European Commision Horizon 2020 grant (H2020-SC1-DTH-2018-2020_H2020-SC1-DTH2019-875358-FAITH) awarded to A.J.O.-M. Funding sources had no role in study design, data collection, analysis, interpretation of data, writing of the manuscript and decision to submit the paper for publication.
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spelling Childhood adversities and the comorbidity between mood and general medical disorders in adultsResults from the WHO World Mental Health Survey PortugalChildhood adversityMood disordersGeneral medical disordersArthritisInflammationSDG 3 - Good Health and Well-beingFunding: The WHO World Mental Health Survey Portugal was carried out by the Department of Mental Health, NOVA Medical School, NOVA University of Lisbon, with collaboration of the CESOP–Portuguese Catholic University and was funded by the Champalimaud Foundation, the Gulbenkian Foundation, the Foundation for Science and Technology (FCT) and the Ministry of Health. TheWHO World Mental Health Survey Portugal was carried out in conjunction with the World Health Organization WMH Survey Initiative which is supported by the National Institute of Mental Health (NIMH; R01MH070884), the John D. and Catherine T. MacArthur Foundation, the Pfizer Foundation, the U.S. Public Health Service (R13-MH066849, R01-MH069864 and R01 DA016558), the Fogarty International Center (FIRCA R03-TW006481), the Pan American Health Organization, Eli Lilly and Company, OrthoMcNeil Pharmaceutical, GlaxoSmithKline and Bristol-Myers Squibb. This study was supported by a NARSAD 2018 Young Investigator Grant (ID: 27,595) awarded to J.O. and a Fundação para a Ciência e Tecnologia (FCT) grant (PTDC/MED-NEU/31,331/2017) and a European Commision Horizon 2020 grant (H2020-SC1-DTH-2018-2020_H2020-SC1-DTH2019-875358-FAITH) awarded to A.J.O.-M. Funding sources had no role in study design, data collection, analysis, interpretation of data, writing of the manuscript and decision to submit the paper for publication.Objective: Childhood adversities have been linked to poor health outcomes in adults, including both mood and general medical disorders. Here we tested the hypothesis that childhood adversities specifically increase the risk of comorbidity between mood and general medical disorders, rather than increasing the risk of either one independently. Methods: Mood disorders (DSM-IV major depressive, dysthymic and bipolar disorders), childhood adversities and general medical disorders were assessed in 2060 adults in the WHO World Mental Health Survey Portugal. Discrete-time survival analyses were used to investigate the association between mood disorders and subsequent first-onset general medical disorders and between general medical disorders and subsequent first-onset mood disorders, in adults. Discrete-time survival and multinomial regression analyses were used to test the influence of childhood adversities on the comorbidity between mood disorders and general medical disorders. Anxiety disorders were used as a psychiatric control. Results: Adult-onset mood disorders were found to precede the onset of diabetes (OR:1.8; 95% CI:1.2-2.9), arthritis (OR:1.6; 95% CI:1.1-2.3) and seasonal allergies (OR:1.6; 95% CI:1.1-2.5) while adult-onset hypertension was found to precede the onset of mood disorders (OR:1.7; 95% CI:1.2-2.6). Maladaptive family functioning (abuse, neglect and parental maladjustment), was associated with mood disorders (OR:1.5; 95% CI:1.2-1.9), hypertension (OR:1.4; 95% CI:1.1-1.7), arthritis (OR:1.3; 95% CI:1.0-1.6) and seasonal allergies (OR:1.5; 95% CI:1.1-2.0) in adulthood. Finally, the effect of maladaptive family functioning in predicting comorbid mood disorders and arthritis significantly differed from its effect in predicting only arthritis (p ​= ​0.01), which was not observed for other comorbidities. Maladaptive family functioning further predicted comorbid anxiety disorders and hypertension. Conclusion: Childhood adversities may be a specific risk factor for comorbid mood disorders and arthritis in adults.Comprehensive Health Research Centre (CHRC) - pólo NMSNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNOliveira, JoséPaixão, VítorCardoso, GraçaXavier, MiguelCaldas de Almeida, José MiguelOliveira-Maia, Albino J2022-07-13T22:27:01Z2021-112021-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/141859eng2666-3546PURE: 42844750https://doi.org/10.1016/j.bbih.2021.100329info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:19:11Zoai:run.unl.pt:10362/141859Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:50:04.707215Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Childhood adversities and the comorbidity between mood and general medical disorders in adults
Results from the WHO World Mental Health Survey Portugal
title Childhood adversities and the comorbidity between mood and general medical disorders in adults
spellingShingle Childhood adversities and the comorbidity between mood and general medical disorders in adults
Oliveira, José
Childhood adversity
Mood disorders
General medical disorders
Arthritis
Inflammation
SDG 3 - Good Health and Well-being
title_short Childhood adversities and the comorbidity between mood and general medical disorders in adults
title_full Childhood adversities and the comorbidity between mood and general medical disorders in adults
title_fullStr Childhood adversities and the comorbidity between mood and general medical disorders in adults
title_full_unstemmed Childhood adversities and the comorbidity between mood and general medical disorders in adults
title_sort Childhood adversities and the comorbidity between mood and general medical disorders in adults
author Oliveira, José
author_facet Oliveira, José
Paixão, Vítor
Cardoso, Graça
Xavier, Miguel
Caldas de Almeida, José Miguel
Oliveira-Maia, Albino J
author_role author
author2 Paixão, Vítor
Cardoso, Graça
Xavier, Miguel
Caldas de Almeida, José Miguel
Oliveira-Maia, Albino J
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Comprehensive Health Research Centre (CHRC) - pólo NMS
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Oliveira, José
Paixão, Vítor
Cardoso, Graça
Xavier, Miguel
Caldas de Almeida, José Miguel
Oliveira-Maia, Albino J
dc.subject.por.fl_str_mv Childhood adversity
Mood disorders
General medical disorders
Arthritis
Inflammation
SDG 3 - Good Health and Well-being
topic Childhood adversity
Mood disorders
General medical disorders
Arthritis
Inflammation
SDG 3 - Good Health and Well-being
description Funding: The WHO World Mental Health Survey Portugal was carried out by the Department of Mental Health, NOVA Medical School, NOVA University of Lisbon, with collaboration of the CESOP–Portuguese Catholic University and was funded by the Champalimaud Foundation, the Gulbenkian Foundation, the Foundation for Science and Technology (FCT) and the Ministry of Health. TheWHO World Mental Health Survey Portugal was carried out in conjunction with the World Health Organization WMH Survey Initiative which is supported by the National Institute of Mental Health (NIMH; R01MH070884), the John D. and Catherine T. MacArthur Foundation, the Pfizer Foundation, the U.S. Public Health Service (R13-MH066849, R01-MH069864 and R01 DA016558), the Fogarty International Center (FIRCA R03-TW006481), the Pan American Health Organization, Eli Lilly and Company, OrthoMcNeil Pharmaceutical, GlaxoSmithKline and Bristol-Myers Squibb. This study was supported by a NARSAD 2018 Young Investigator Grant (ID: 27,595) awarded to J.O. and a Fundação para a Ciência e Tecnologia (FCT) grant (PTDC/MED-NEU/31,331/2017) and a European Commision Horizon 2020 grant (H2020-SC1-DTH-2018-2020_H2020-SC1-DTH2019-875358-FAITH) awarded to A.J.O.-M. Funding sources had no role in study design, data collection, analysis, interpretation of data, writing of the manuscript and decision to submit the paper for publication.
publishDate 2021
dc.date.none.fl_str_mv 2021-11
2021-11-01T00:00:00Z
2022-07-13T22:27:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/141859
url http://hdl.handle.net/10362/141859
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2666-3546
PURE: 42844750
https://doi.org/10.1016/j.bbih.2021.100329
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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